熊果酸的提取工艺、生物活性及作用机制研究进展

Research progress on extraction technology, biological activity and mechanism of ursolic acid

中文关键词:  熊果酸  提取工艺  生物活性

英文关键词:ursolic acid  extraction technology  biological activity  mechanism

中文摘要:

      熊果酸是一种存在于水果、蔬菜和中草药等天然植物中的五环三萜类化合物, 具有多种生物学效应, 在食品、药品和化妆品开发方面具有广阔的应用前景。熊果酸结构复杂, 难以通过化学手段合成, 从天然植物中提取分离是获取熊果酸的主要途径。本文概述了熊果酸的传统和新型提取工艺, 总结了熊果酸在抗氧化、抗炎、抗肿瘤、保护肝脏和心脏、改善糖脂代谢紊乱等方面的生物活性和作用机制, 并对熊果酸未来研究方向进行展望, 以期为后续熊果酸的生物活性和作用机制研究, 为其在食品与医药领域的开发应用提供理论依据。

英文摘要:

      Ursolic acid is a pentacyclic triterpenoid compound found in natural plants such as fruits, vegetables and Chinese herbal medicines. It has a variety of biological effects and has broad application prospects in food, medicine and cosmetics. Ursolic acid is difficult to be synthesized by chemical means because of its complex structure. The main way to obtain ursolic acid is to extract and isolate it from natural plants. According to the extraction technology of ursolic acid, this paper firstly summarized the traditional extraction methods, such as solvent extraction and soxhlet extraction, and the new extraction methods in recent years, including ultrasonic assisted extraction, microwave assisted extraction, and subcritical/supercritical fluid extraction. This paper summarized the traditional extraction methods and new extraction methods of ursolic acid in recent years and the biological activity and mechanism of ursolic acid in antioxidant, anti-inflammatory, anti-tumor, liver and heart protection, and improvement of glucose and lipid metabolism disorders, and prospected the future research direction of ursolic acid, which is expected to provide a theoretical basis for the subsequent research on the biological activity and mechanism of ursolic acid, as well as the development and application in the field of food and medicine.