β-紫罗兰酮的生物活性与其衍生物的构效关系研究进展

Research progress on bioactivities of β-ionone and structure-function relationship of its derivatives

中文关键词:  β-紫罗兰酮  生物活性  衍生物  构效关系

英文关键词:β-ionone  bioactivities  derivatives  structure-function relationship

中文摘要:

      β-紫罗兰酮是形成维甲酸、视黄醇、β-胡萝卜素和维生素A基本核结构的环萜化合物, 主要来源于天然食物中。β-紫罗兰酮具有抗癌、抗炎、抗氧化、抗锥虫、驱虫等多种生物活性, β-紫罗兰酮衍生物的化学结构与其活性关系密切, β-紫罗兰酮衍生物邻间对位会影响其活性, 不同位点的不同的取代基也会影响其活性。本文综述了β-紫罗兰酮的理化性质、生理活性及其衍生物构效关系的研究进展, 发现β-紫罗兰酮在抗癌方面作用和机制研究领域较为成熟, 其生理活性可以通过化学修饰得以加强, 未来可以作为新型抗癌食品、药物原料进行开发, 亦具有开发为抗氧化剂的潜力和可能, 本文可为β-紫罗兰酮深层次开发和应用提供理论参考和研究方向。

英文摘要:

      β-ionone is a cycloterpene compound that forms the basic nuclear structure of retinoic acid, retinol, β-carotene, and vitamin A. It is mainly derived from natural foods. β-ionone has a variety of biological activities, such as anti-cancer, anti-inflammatory, anti-oxidation, anti-trypanosoma, and deworming. The activity of β-ionone derivatives is closely related to their chemical structures. Its neighbor, interposition and counterpart will affect its activity, and different substituents at different sites will also affect its activity. This paper summarized the research progress on the physicochemical property, physiological activity of β-ionone and structure-activity relationship of its derivatives. It has been discovered that β-ionone is relatively mature in the research field of anti-cancer action and mechanism, moreover, its physiological activity can be enhanced by chemical modification, which can be used as new anti-cancer food and drug raw materials in the future and has the potential to be developed as an antioxidant. This paper can provide theoretical references as well as a research direction for the future development and application of β-ionone.