海洋源活性多糖的免疫调节作用研究进展

Advances in immunomodulatory effects of marine-derived active polysaccharides

中文关键词:  海洋动物多糖  海洋植物多糖  免疫调节

英文关键词:marine animal polysaccharide  marine plant polysaccharide  immunomodulation

中文摘要:

      免疫调节通过免疫系统来维持人体的生理动态平衡与相对稳定。免疫细胞和免疫分子以及与其他系统的相互作用可以使机体维持在最适当的水平。海洋动植物中存在着许多的天然活性多糖, 这些活性多糖具有的重要生物活性之一就是免疫活性。目前, 多糖的免疫调节作用引起了国内外学者的广泛关注, 从海洋动植物中获取具有免疫调节作用的活性多糖也成为一种趋势。本文在对海洋动植物多糖的种类来源及生物活性进行介绍的基础上, 分别从多糖对免疫器官、特异性与非特异性免疫的影响、免疫信号通路等方面综述了海洋动植物多糖的免疫调节作用及作用机制, 并就海洋动物多糖的免疫活性的机制研究方面进行了展望, 以期为海洋源活性多糖的免疫调节作用的相关研究提供参考。

英文摘要:

      Immunomodulation is the process by which the immune system maintains the body’s physiological dynamic equilibrium and relative stability. Immune cells and molecules, as well as their interactions with other systems, maintain the body at the most appropriate level. There are many natural active polysaccharides in marine animals and plants, and one of the important biological activities of these active polysaccharides is immune activity. At present, the immunomodulatory effect of polysaccharides has attracted wide attention of scholars at home and abroad, it is also a trend to obtain active polysaccharides with immunomodulatory effect from marine animals and plants. Based on the introduction of the species and biological activities of marine animal and plant polysaccharides, this paper reviewed the immunomodulatory effects and mechanisms of marine animal and plant polysaccharides on immune organs, specific and hapten effects, and immune signaling pathways, and prospected the research on the immune mechanism of marine animal polysaccharides, which can be used as a reference for the study on the immune regulation of marine-derived active polysaccharides.