牡蛎提取物对雄性大鼠性功能的影响

Effect of oyster extract on sexual function of male rats

中文关键词:  牡蛎提取物  性功能  半去势大鼠  交配试验

英文关键词:oyster extract  sexual function  hemi-castrated rat  mating test

中文摘要:

      目的 探究牡蛎提取物对正常雄性大鼠和半去势大鼠的性功能的影响。方法 将40只雄性SD (Sprague Dawley)大鼠随机分为4组, 各组分别灌胃受试物或纯净水, 连续灌胃30 d后进行交配试验, 并测定大鼠阴茎勃起时间。将50只雄性大鼠随机分为5组, 除正常对照组外, 其余大鼠摘除右侧睾丸, 各组分别灌胃受试物或纯净水, 连续灌胃30 d, 然后称重雄性大鼠的包皮腺、精囊腺和前列腺，测定勃起潜伏期、血清皮质醇、促黄体生成素和睾酮水平。结果 与正常对照组相比, 牡蛎提取物低、中、高剂量组均能提高大鼠的射精次数(P<0.05), 高剂量牡蛎提取物能同时提高大鼠的捕捉次数和射精率(P<0.05)。与半去势大鼠模型对照组相比, 牡蛎提取物中、高剂量组的大鼠包皮腺系数有明显增高(P<0.05), 促黄体生成素含量显著降低(P<0.01), 高剂量组大鼠的血清皮质醇含量升高(P<0.05)。结论 牡蛎提取物具有一定的雄激素样作用, 能改善大鼠性功能。

英文摘要:

      Objective To study the effects of oyster extract on sexual function of normal rats and hemi-castrated rats. Methods 40 male rats were randomly divided into 4 groups, each group was given continuous intragastric administration of test substances and pure water for 30 days, mating test was performed, and the erectile times of rats were measured. 50 male rats were randomized into 5 groups, except for the normal control group, the right testis of other rats were removed, each group was given intragastric administration of test substances and pure water for 30 d, and then the preputial glands, seminal vesicles and prostate glands of male rats were all weighed, the erection latency, serum cortisol, luteinizing hormone and testosterone were measured. Results Compared to normal control group, low, medium and high oyster extract dose could improve the capture counts of normal rats (P<0.05), and the high oyster extract dose could simultaneously improve the ejaculation counts and ejaculation rates of rats (P<0.05). Compared with the control group of hemi-castrated rat model, the preputial glands coefficients of hemi-castrated rats were increased significantly in medium and high oyster extract dose groups (P<0.05), the luteinizing hormone concentration were decreased significantly in hemi-castrated rats (P<0.01), and the cortisol of the high oyster extract dose group were increased significantly (P<0.05). Conclusion Oyster extracts have androgen like effect, and can improve sexual function of rats.