肠道菌群与婴幼儿食物过敏相关性的研究进展

Research progress of correlation between intestinal flora and infant food allergy

中文关键词:  肠道菌群  食物过敏  益生菌  免疫反应

英文关键词:intestinal flora  food allergy  probiotics  immune response

中文摘要:

      随着婴幼儿食物过敏的发病率逐年上升, 食物过敏逐渐成为了全球性公共卫生问题。大量研究表明, 人体内肠道菌群与食物过敏有着密切的关系, 在受到外界因素的干扰后, 肠道菌群多样性和数量发生改变, 进而可能引发机体对某些正常抗原的免疫耐受度降低, 导致过敏反应。本文介绍了食物过敏婴幼儿和健康婴幼儿肠道菌群的差别, 对肠道菌群影响肠道细胞功能和调节屏障保护特性、产生信号分子进行免疫调控以及促进和维护机体口服耐受等在食物过敏中的调节机制进行综述, 并对肠道菌群调节婴幼儿食物过敏的策略进行展望。

英文摘要:

      With the increasing incidence of food allergies in infants and young children, food allergies have gradually become a global public health problem. A large number of studies have shown that intestinal flora is closely related to food allergies. After being disturbed by external factors, the diversity and quantity of the intestinal flora change, which may trigger a reduction in the body's immune tolerance to certain normal antigens, leading to allergic reactions. This article introduced the difference between the intestinal flora of infants with food allergies and healthy infants, reviewed the regulatory mechanisms of intestinal flora in food allergy, such as affecting intestinal cell function and regulating barrier protective characteristics, producing signal molecules for immune regulation, and promoting and maintaining oral tolerance, and prospected the strategies of intestinal flora to regulate infants’ food allergies.