非变性Ⅱ型胶原蛋白改善骨关节炎的研究进展

Research progress of undenatured type Ⅱ collagen in improving osteoarthritis

中文关键词:  非变性Ⅱ型胶原蛋白  骨关节炎  口服免疫耐受  机制

英文关键词:undenatured typeⅡ collagen  osteoarthritis  oral immune tolerance  mechanism

中文摘要:

      随着人口老龄化的到来, 骨折和骨关节炎患病人群呈现大幅度增高趋势, 严重的危害着老年人的身体健康。作为世界上发病率和致残性都比较高的疾病, 关节炎的致残率高达53%。但是关节炎远没有骨质疏松症那样备受重视, 尤其是中国, 骨关节炎患者数量巨大, 目前普遍用于改善关节炎症状的药物有糖皮质激素、非甾体类抗炎药、营养补充剂如硫酸软骨素、氨基葡萄糖、透明质酸等, 研究表明药物治疗会带来副作用, 而营养补充剂的效果也存在争议。非变性II型胶原蛋白(也称之为含II型胶原蛋白的软骨粉)在20世纪90年代初开始用于治疗人体的关节炎, 效果良好, 备受关注。本文主要阐述了非变性Ⅱ性胶原蛋白在改善关节炎方面国内外的动态及前沿研究进展, 以及对其作用机制的研究, 通过研究发现非变性Ⅱ型胶原蛋白对改善关节炎的症状具有非常重要作用及功能, 其具有非常广阔的市场开发前景。

英文摘要:

      With the arrival of the aging population, the prevalence rate of osteoporosis and its related fractures and osteoarthritis increases gradually, which seriously harms the health of the elderly. Arthritis is a disease with high morbidity and disability in the world, with a disability rate of 53%. However, arthritis is far less important than osteoporosis. Especially in China, there are a large number of patients with osteoarthritis. Currently, the drugs commonly used to improve the symptoms of arthritis include glucocorticoids, non steroidal anti-inflammatory drugs, nutritional supplements such as chondroitin sulfate, glucosamine, hyaluronic acid, etc. Studies show that drug treatment will bring side effects, and the effect of nutritional supplements is controversial. Undenatured type-II collagen (UC-II) (also known as collagen II-containing perichondrome) has been used in the treatment of human arthritis since the early 1990s, with good effect and attracted much attention. This paper mainly expounds the dynamic and frontier research progress of undenatured type II collagen in improving arthritis at home and abroad, as well as the research on its mechanism. Through the research, it is found that non denaturing type II collagen has a very important role and function in improving the symptoms of arthritis, and it has a very broad market development prospect.