水溶性雨生红球藻虾青素粉对小鼠抗疲劳功能研究

Study on the anti-fatigue function of water soluble astaxanthin powder from Haematococcus pluvialis in mice

中文关键词:  虾青素  抗疲劳  负重游泳  血尿素氮  乳酸  肝糖原

英文关键词:astaxanthin  anti-fatigue  weight-bearing swim  serum urea nitrogen  lactic acid  glycogen

中文摘要:

      目的 研究水溶性雨生红球藻虾青素粉对正常小鼠抗疲劳功能的影响。方法 取SPF级ICR雄性小鼠160只随机分为4组, 每组40只, 水溶性雨生红球藻虾青素粉设低、中、高3个剂量组分别为25、50、 150 mg/kg bw, 另设溶剂对照组。小鼠连续给受试样品30 d后进行负重游泳试验并测定血清尿素氮、肝糖原、血清乳酸含量。结果 水溶性雨生红球藻虾青素粉各剂量组小鼠增重与对照组比较差异无统计学意义(P＞0.05), 高剂量组负重游泳时间显著延长(P<0.05); 高剂量组与对照组比较血清尿素氮显著性降低(P<0.05), 血清乳酸显著性降低(P<0.05), 肝糖原显著性增高(P<0.05)。结论 水溶性雨生红球藻虾青素粉具有缓解体力疲劳功能, 本研究为虾青素的开发利用提供一定的科学依据。

英文摘要:

      Objective To observe the anti-fatigue effect of water soluble astaxanthin powder from Haematococcus pluvialis on mice. Methods 160 male ICR mice of SPF were randomly divided into four groups with 40 mice in each group. The dosage of water soluble astaxanthin powder from Haematococcus pluvialis was 25, 50 and 150 mg/kg bw respectively, and another solvent control group was set up. After 30 days of continuous administration of the test sample, the mice were tested by weight-bearing swimming test and the contents of serum urea nitrogen (BUN), liver glycogen and serum lactate were determined. Results There was no significant difference in weight gain between each dose group and the control group (P＞0.05), The swimming time in high dose group was significantly prolonged (P<0.05). Compared with the control group, the serum urea nitrogen in the high dose group decreased significantly (P<0.05), the serum lactate significantly decreased (P<0.05), and glycogen in liver significantly increase (P<0.05). Conclusion Water soluble astaxanthin powder from Haematococcus pluvialis has the function of alleviating physical fatigue. This study provides a scientific basis for the development and utilization of astaxanthin.