巴戟天和天麻复合物改善睡眠作用的研究

Effect of Morinda officinalis and Gastrodia elata compound on improving sleep

中文关键词:  巴戟天  天麻  改善睡眠

英文关键词:Morinda officinalis  Gastrodia elata  improving sleep

中文摘要:

      目的 评价巴戟天和天麻复合物改善睡眠的作用。方法 巴戟天和天麻复合物分别以0.175、0.35、0.70 g/kg剂量给小鼠连续灌胃给药30 d后, 通过直接睡眠实验、延长戊巴比妥钠睡眠时间实验、戊巴比妥钠阈下剂量催眠实验和巴比妥钠睡眠潜伏期实验来观察小鼠睡眠相关指标。结果 与阴性对照组相比, 该复合物3个剂量显著延长小鼠在戊巴比妥钠睡眠实验中的睡眠时间(P<0.05), 明显缩短巴比妥钠睡眠潜伏期(P<0.05), 但该复合物对直接睡眠无影响, 未增加戊巴比妥钠阈下剂量诱导的小鼠睡眠发生率(P>0.05)。结论 受试物具有改善小鼠睡眠的作用。

英文摘要:

      Objective To evaluate the effect of Morinda officinalis and Gastrodia elata compound on improving sleep. Methods The compounds were consistently administered intragastricly to mice by gavage at doses of 0.175, 0.35, 0.70 g/kg for 30 d. Subsequently, sleeping index of mice were evaluated in the direct sleep test, the extending test with sodium pentobarbital, the hypnosis test under subthreshold dose of sodium pentobarbital, and the incubation period test with barbital sodium. Results Compared with the control group, the compounds prolonged the sleep time of sodium pentobarbital with all the dose group (P<0.05) and shorten the sleep latency of barbital in the middle and high dose group (P<0.05). However, the compounds had no effect on direct sleep, and did not increase the incidence of sleep induced by subthreshold dosage of pentobarbital sodium (P>0.05). Conclusion The compounds can improve the sleeping quality of mice.