醇提蛋黄油对胃粘膜损伤的辅助保护功能评价

Evaluation of auxiliary protection function of alcohol extracted egg yolk oil on gastric mucosal injury

中文关键词:  蛋黄油  SD大鼠  胃粘膜损伤  保护功能

英文关键词:egg yolk oil  sprague dawley rats  gastric mucosa damage  protective function

中文摘要:

      目的 探索无水乙醇提取的蛋黄油对胃粘膜损伤的辅助保护功能。方法 将50只雄性SD大鼠随机分为空白对照组、模型对照组、以及低[1250 mg/(kg?BW)]、中[2500 mg/(kg?BW)]、高[5000 mg/(kg?BW)]剂量组, 每组10只。对乙酸致SD大鼠慢性胃溃疡模型组, 分组灌胃蛋黄油14 d后对大鼠胃进行观察和组织病理学检查。结果 1250、2500 mg/(kg?BW)剂量组胃溃疡面积低于模型对照组(P＜0.05), 1250、2500、5000 mg/(kg?BW)剂量组的胃溃疡体积和病理组织学检查评分低于模型对照组(P＜0.01)。结论 醇提蛋黄油对SD大鼠慢性胃溃疡有保护功能。

英文摘要:

      Objective To explore the auxiliary protection function of absolute alcohol extracted egg yolk oil on gastric mucosal injury. Methods Totally 50 male Sprague Dawley rats were randomly divided into negative control group, model control group, and low, medium and high dose groups[1250 mg/(kg?BW), 2500 mg/(kg?BW), 5000 mg/(kg?BW)], each group was 10 rats. In the model group of SD rats with chronic gastric ulcer induced by acetic acid, the gastric contents of the rats were observed and histopathologically examined after 14 days of egg yolk oil administration. Results The area of rats gastrohelcosis were lower in the does of 1250 mg/(kg?BW) and 2500 mg/(kg?BW) than in the model control(P＜0.05), the volume of rats gastrohelcosis and histopathological sore were lower in the does of 1250 mg/(kg?BW) 2500 mg/(kg?BW) and 5000 mg/(kg?BW) than model control group(P＜0.01). Conclusion The alcohol extraction egg yolk oil has protective function on rats gastric mucosa damage.