药食同源类中药在P-糖蛋白介导的多药耐药中的应用

Application of medicinal and edible traditional Chinese medicine in multidrug resistance mediated by P-glycoprotein

中文关键词:  中药  肿瘤  多药耐药  P-糖蛋白  药食同源

英文关键词:traditional Chinese medicine  tumor  multidrug resistance  p-glycoprotein  drug and food homology

中文摘要:

      目前, 肿瘤细胞产生多药耐药(multidrug resistance, MDR)严重制约了化疗疗效, 由多药耐药基因编码的P-糖蛋白(P-glycoprotein, P-gp)的过表达是多药耐药产生的重要原因之一。我国中药资源丰富, “药食同源”历史悠久, 药食两用类中药, 安全性高, 毒副作用小, 可通过多成份, 多靶点、多途径来预防和治疗肿瘤。本文根据P-gp介导MDR机制, 介绍了部分可以抑制P-gp实现逆转MDR的“药食同源”类中药, 为肿瘤的预防和辅助治疗提供新思路。

英文摘要:

      At present, multidrug resistance (MDR) in tumor cells severely restricts the efficacy of chemotherapy. Overexpression of P-glycoprotein (P-gp) encoded by multidrug resistance gene is one of the important reasons for multidrug resistance. Traditional Chinese medicine resources are rich and "one root of medicine and food" has a long history. Medicinal and edible traditional Chinese medicine, with many advantages such as high safety and poor side effects, can prevent and treat tumors through multiple components, multiple targets and multiple ways. Based on the mechanism of P-gp mediated MDR, this article introduced some medicinal and edible traditional Chinese medicine, which could reverse the MDR by inhibiting P-gp and provided new ideas for prevention and assisted therapy of tumors.