液相色谱-串联质谱技术在食品药品安全分析领域的应用

Application of liquid chromatography-tandem mass spectrometry in food and drug safety analysis

中文关键词:  超高效液相色谱  质谱  食品安全  药品安全

英文关键词:ultra performance liquid chromatography  mass spectrometry  food safety  drug safety

中文摘要:

      液相色谱(liquid chromatogram, LC)在分离能力、灵敏度和专属性等方面有着巨大优势, 与质谱(mass spectrometry, MS)联用后可以展现出强大的定性、定量分析能力, 并已经在农兽药残留、非法添加、有毒物质研究等各领域得到广泛应用。本文对液相色谱-串联质谱(liquid chromatography-tandem mass spectrometry, LC-MS/MS)技术在食品相关国家标准, 如农残、兽残、食品接触类材料, 及《中华人民共和国药典(2015版)》中的应用进行了简单介绍, 并介绍了本部门在食品安全、药品安全、食品接触类塑料制品残留物分析等领域取得的工作进展。

英文摘要:

      Liquid chromatography (LC) has great advantages in the capacity of separation, sensitivity and specificity, and mass spectrometry (MS) can be combined to show strong qualitative and quantitative analysis capabilities, and they have been found widespread application in the food safety analysis, particularly in the analysis of pesticide residues, veterinary drug residues, illegal additives and toxic substances. This paper reviewed the application of liquid chromatography-tandem mass spectrometry (LC-MS/MS) in the fields of pesticide residues, veterinary drug residues and food contact materials of national food standards and pharmacopoeia of China, and introduced the research progress of food safety, drug safety and residues in food plastic materials of our group.