缺铁性贫血与补铁剂研究概况

Research progress on iron deficiency anemia and new types of iron supplement agents

中文关键词:  缺铁性贫血  补铁剂  多糖铁复合物  多肽铁复合物  富铁酵母

英文关键词:iron deficiency anemia  iron supplement agents  polysaccharide-iron complex  ferrous-chelating peptides  iron-enriched yeast

中文摘要:

      缺铁性贫血是世界范围内最普遍的营养素缺乏症之一, 严重影响着人们的身体健康。铁摄入不足和过大消耗是造成缺铁性贫血的常见原因。因此, 摄入足量的铁是预防和治疗缺铁性贫血的有效办法。科学工作者们一直致力于安全、有效的补铁剂的研究。目前补铁剂主要包括: 以硫酸亚铁为代表的第一代补铁剂, 以乳酸亚铁为代表的第二代补铁剂和近些年兴起的以大分子螯合铁为代表的第三代补铁剂。第三代补铁剂较第一、二代不仅具有吸收利用度好、副作用少、性质稳定等优点, 而且其中大分子螯合剂还具有抗氧化、抑菌、免疫调节等生物活性, 因而越来越受到人们的青睐, 也成为了科研工作者的重点研究对象。本文围绕缺铁性贫血与人类健康、补铁剂研究历史、多糖铁复合物、多肽铁复合物以及富铁酵母等新型补铁剂的研究现状进行综述。

英文摘要:

      Iron deficiency anemia (IDA) is one of the most common nutrient deficiency diseases in the world, seriously affecting the health of human. Inadequate intake and excessive loss are common reasons of iron deficiency anemia. It is an effective method to take enough iron to prevent and treat iron deficiency anemia. Therefore, the safety and effectiveness of iron supplement agents have always been the focus of studies. Iron supplement agents mainly include 3 stages: ferrous sulfate, ferrous lactate and iron-chelating macromolecular are the representative iron supplement agents of the first, the second and the third stage, respectively. Iron supplement agents of the third stage own the advantages of high bioavailability, less side effects, food stability. Meanwhile, macromolecule chelating agents have antioxygenation, antimicrobial activity, immunoregulation and other biological activities, so that iron- chelating macromolecular has been attracting more and more attention of people and becoming the key study object for scientists. This article mainly summarized iron deficiency anemia and human health, the development history of iron supplement agents, and the recent research of polysaccharide-iron complex, ferrous-chelating peptides and iron-enriched yeast.