研发光散射探针拓展光谱手性识别的研究进展

Research progress of spectral chiral recognition by development of light scattering probe

中文关键词:  手性识别  光谱分析  共振瑞利散射(RRS)  光散射探针

英文关键词:chiral recognition  spectral analysis  resonance rayleigh scattering  light scattering probe reagent

中文摘要:

      手性对映体主导着自然的奇妙和生命的奥秘。生命组织中的手性环境能自然开启手性识别和激活手性, 而人为介入的手性识别需要高灵敏度和高选择性相结合的分析手段。共振瑞利散射(RRS)光谱是一种高灵敏度且简便易行的分析方法, 以有机染料、纳米粒子或量子点等作为光散射探针结合高灵敏度的RRS光谱, 不仅能增强光散射, 提高灵敏度, 还能有效提高共振光散射光谱的选择性。而探索合成羟基氨基喹啉类衍生物手性光散射探针试剂与RRS相结合的手性识别则是一项创新工作。须确定羟基氨基喹啉类衍生物手性光散射探针试剂的作用机制以及分类筛选的应用研究, 发展以手性光散射探针试剂为主导的识别手性对映体的RRS光谱分析, 进一步拓展确立不经分离而同时测定手性对映体的新分析方法研究。

英文摘要:

      Chiral enantiomers dominated natural wonders and the mysteries of life. Only the chiral environment in life organization could open up the chiral recognition and activation of the chirality naturally but human intervention in the chiral recognition by the special analytical means of combining high sensitivity and high selectivity. Resonance rayleigh scattering (RRS) spectrum is a kind of high sensitivity and simple analysis method, and the RRS spectra with high sensitivity had the organic dyes, nanoparticles or quantum dots for light scattering probe reagent, not only enhanced its light scattering, improved the sensitivity, could also effectively improve its selectivity. To explore the synthetize of hydroxyl, amino quinoline derivatives for chiral light scattering probe reagent to combine with RRS for chiral recognition is an innovative work, to confirm the mechanism of hydroxyl, amino quinoline derivatives for chiral light scattering probe reagent and to develop the new method of RRS spectral analysis dominated by chiral light scattering probe reagent of organic enantiomers in chiral recognition, further to establish a new analysis method for simultaneously determination of chiral enantiomers without separation firstly.