姓名：孟晶

性别：女

学历：博士研究生

职称：副教授

工作单位：天津科技大学

教育情况：

2014.9-2017.12 南开大学 药学院 化学生物学 理学博士

2011.9-2014.6 南开大学 生命科学学院 生物化学与分子生物学 理学硕士

工作经历：

2018.01-2020.01  南开大学  药物化学生物学国家重点实验室  博士后

2020.01-至今   天津科技大学 食品营养与安全国家重点实验室  副教授

所主持的项目及其进展：

1. 国家自然科学基金面上项目，YY1-EP300复合体通过促进SOAT1介导的胆固醇调节诱导肝癌EMT的机制研究，主持，在研

2. 国家自然科学基金青年项目，Twist1-YY1-p300相分离转录复合体结合超级增强子调控miRNA9表达促进肝癌EMT的分子机制研究，主持，已结题

3. 天津市自然科学基金面上项目，MRG15转录复合体节律性调控SOAT1介导胆固醇代谢诱导肝癌EMT的机制研究，主持，在研

4. 博士后创新人才支持计划，基于G-四链体结构稳定的单链环状DNA的抗肿瘤作用研究，主持，已结题

5. 博士后自然基金，Twist1复合体结合超级增强子调控miRNA-9促进肝癌EMT，主持，已结题

6. 博士后自然基金，SOAT1转录调控介导的胆固醇稳态诱导肝癌EMT机制研究，主持，已结题

7. 国家重点研发计划，动物源食品重要功能物质挖掘评价与功效机制研究，参与，在研

所受奖项：

入选天津市创新人才推进计划青年科技优秀人才；博士后创新人才支持计划；天津向上向善好青年；天津市企业科技特派员；海新区知识产权专家库入库专家。

主要研究方向：

主要进行疾病机理与营养代谢调控研究，涉及到药食同源资源开发利用。

代表性著作：

1. RR Fu, LC Wang, WQ Xue, JJ Liang, J Meng*, M Zhang*. Nootkatone suppresses TLR4/NF-κB/NLRP3 pathway to alleviate non-alcoholic fatty liver disease via modulating gut microbiota. Food Science and Human Wellness, 2025, 14.

2. RR Fu, WQ Xue, JJ Liang, XR Li, J Zheng, LC Wang, M Zhang*, J Meng*. SOAT1 regulates cholesterol metabolism to induce EMT in hepatocellular carcinoma. Cell Death and Disease. 2024,15(5):325.

3. JX Han#, R Qin#, ST Zheng, XH Hou, XR Wang, HH An, ZW Li, YN Li, H Zhang, DH Zhai, HJ Liu*, J Meng* and T Sun*. MSC microvesicles loaded G-quadruplex enhanced circular single-stranded DNA-9 inhibits tumor growth by targeting MDSCs. Journal of Nanobiotechnology. 2024, 22:237.

4. LC Wang#, RR Fu#, Y Meng#, JJ Liang, WQ Xue, HT Hu, J Meng* and M Zhang*. pH Sensitive Quercetin Nanoparticles Ameliorate DSS-Induced Colitis in Mice by Colon-Specific Delivery. Molecular Nutrition and Food Research, 2024, 68, 2300051.

5. LC Wang#, GT Jia#，RR Fu，JJ Liang, WQ Xue, J Zheng, Y Qin, M Zhang*, J Meng*. Hepatic miR-363 promotes nonalcoholic fatty liver disease by suppressing INSIG1. Journal of Nutritional Biochemistry, 2024, 134, 109717.

6. J Meng #, JX Han #, XR Wang, T Wu, H Zhang, HH An, LN Qin, Y Sun, WL Zhong, C Yang*, HJ Liu*, T Sun*. Twist1-YY1-p300 complex promotes the malignant progression of HCC through activation of miR-9 by forming phase-separated condensates at super enhancers and relieved by metformin, Pharmacological Research, 2023, 188(106661).  

7. J Mao, YJ Zhao, LC Wang, T Wu, Y Jin, J Meng* and M Zhang*. Sea Cucumber Peptide Alleviates Ulcerative Colitis Induced by Dextran Sulfate Sodium by Alleviating Gut Microbiota Imbalance and Regulating miR-155/SOCS1 Axis in Mice. Foods, 2023, 12, 3434.

8. RR Fu#, LC Wang#, Y Meng#, WQ Xue, JJ Liang, ZM Peng, J Meng* and M Zhang*. Apigenin remodels the gut microbiota to ameliorate ulcerative colitis, Frontiers in Nutrition, 2022, 9:1062961.

9. J Mao, ZC Zhang, YD Chen, T Wu, Viktor Fersht, Y Jin, J Meng* and Min Zhang*, Sea cucumber peptides inhibit the malignancy of NSCLC by regulating miR-378a-5p targeted TUSC2, Food and Function, 2021, 12, 12362-12371.

10. J Meng#, XY Ai #, YY Lei #, WL Zhong #, BX Qian, KL Qiao, XR Wang, BJ Zhou. HZ Wang. LC Huai, XY Zhang, JX Han, YY Xue, Y Liang, HG Zhou *, S Chen *, T Sun *, C Yang*. USP5 promotes epithelial–mesenchymal transition by stabilizing SLUG in hepatocellular carcinoma, Theranostics, 2019, 9(2): 573-587.

11. JX Han #, J Meng#, S Chen #, XR Wang #, S Yin#, Q Zhang, HJ Liu, R Qin, ZW Li, WL Zhong, C Zhang, H Zhang, YH Tang, TT Lin, WF Gao, XY Zhang, L Yang, YR Liu, HG Zhou, S Chen, T Sun *, C Yang*. YY1 complex promotes Quaking expression via super-enhancer binding during EMT of hepatocellular carcinoma, Cancer Research, 2019, 79(7): 1451-1464.

12. WD Yang, ZW Li, R Qin, XR Wang, HH An, YL Wang, Y Zhu, YR Liu, SJ Cai, S Chen, T Sun*, J Meng* and C Yang*. YY1 promotes endothelial cell-dependent tumor angiogenesis in hepatocellular carcinoma by transcriptionally activating VEGFA, Frontiers in Oncology, 2019, 9: 1187.  

13. J Meng #, S Chen #, JX Han, Q Tan, XR Wang, HZ Wang, WL Zhong, Y Qin, KL Qiao, C Zhang, WF Gao, YY Lei, HJ Liu, YR Liu, HG Zhou, T Sun *, C Yang *. Derepression of co-silenced tumor suppressor genes by nanoparticle-loaded circular ssDNA reduces tumor malignancy, Science Translational Medicine,2018, 10(442): eaao6321.

14. J Meng #, S Chen #, JX Han #, BX Qian#, XR Wang, WL Zhong, Y Qin, H Zhang, WF Gao, YY Lei, W Yang, L Yang, C Zhang, HJ Liu, YR Liu, HG Zhou, T Sun *, C Yang *. Twist1 Regulates Vimentin through Cul2 Circular RNA to Promote EMT in Hepatocellular Carcinoma, Cancer Research, 2018, 78(15): 4150-4162.

15. J Meng, YR Liu, JX Han, Q Tan, S Chen, KL Qiao, HG Zhou, T Sun*, C Yang *. Hsp90β promoted endothelial cell-dependent tumor angiogenesis in hepatocellular carcinoma, Molecular Cancer. 2017, 16(1):72.