姓名:董彩虹
性别:女
学历:博士研究生
职称:研究员
工作单位:中国科学院微生物研究所
教育情况:
1997年硕士毕业于华中农业大学
2006年博士毕业于中国科学院微生物研究所。
工作经历:
1997年7月任职于三峡大学,历任讲师和副教授。2006年任职于中科院微生物研究所副研究员,2014 年晋升为研究员。现为中国菌物学会菌物产业分会会长、中国菌物学会虫草产业分会会长、中国中药协会茯苓产业分会副秘书长、中国食用菌协会理事、辽宁省功能性蛹虫草重点实验室学术委员会主任、中国北方虫草谷产业技术研究院名誉院长、京明合作科技特派员。《菌物学报》、《食用菌学报》、《微生物学杂志》、《菌物研究》、《International Journal of Environmental Research and Public Health》、《Frontiers in Microbiology》和《Frontiers in Fungal Biology》编委。
所主持的项目及其进展:
承担国家重点研发课题、中国科学院STS计划、国家自然科学基金、北京市科技计划等多项课题研究。
1、建立了蛹虫草和金针菇无痕基因编辑技术体系,并首次应用基因编辑技术对蛹虫草进行菌种改良,得到无稻曲菌素产生和抗病性增强的蛹虫草菌株,目前已经申请PCT专利。
2、组装得到白肉灵芝、蛹虫草、冬虫夏草、茯苓和大球盖菇染色体水平T2T高质量基因组,阐明白肉灵芝基因组染色体结构,为重要性状基因挖掘奠定基础;挖掘得到蛹虫草抗病相关基因,并在菌种改良中得到应用。
3、选育得到蛹虫草、灰树花和茯苓优良菌种并在企业转化应用。
所受奖项:
2018年,获广东省科学进步奖一等奖
主要研究方向:
珍稀食药用菌生物学,从事基因组解析基础上的优良性状相关基因挖掘和基因编辑技术研究。涉及类群包括具有重要经济价值的珍稀种类冬虫夏草、蛹虫草、灵芝、白肉灵芝、羊肚菌、金针菇、茯苓和大球盖菇。发表论文100余篇,授权专利10项,参编《中国冬虫夏草》、《食用菌栽培学》和《食用菌遗传育种学》。
代表性著作:
Liu Q, Dong CH*. 2023. Dual Transcriptomics reveals interspecific interactions between the mycoparasite Calcarisporium cordycipiticola and its host Cordyceps militaris. Microbiology Spectrum. 22:e0480022. doi: 10.1128/spectrum.04800-22.
Yang Y, Liu Q, Zhang ZX, Dong CH*. 2023. First report of bacterial brown rot disease caused by ewingella americana on cultivated Naematelia aurantialba in China. Plant Dis. doi: 10.1094/PDIS-10-22-2499-PDN.
Li X, Liu MQ, Dong CH*. 2023. Hydrophobin gene Cmhyd4 negatively regulates fruiting body development in edible fungi Cordyceps militaris. International Journal of Molecular Sciences. 24(5):4586. doi: 10.3390/ijms24054586.
Meng GL, Wang XP, Liu MQ, Wang F, Liu Q, Dong CH*. 2022. Efficient CRISPR/Cas9 system based on autonomously replicating plasmid with an AMA1 sequence and precisely targeted gene deletion in the edible fungus, Cordyceps militaris. Microbial Biotechnology. 15: 2594-2606.
Li SJ, Meng GL, Dong CH*. 2022. Homokaryotic high-quality genome assembly of medicinal fungi Wolfiporia hoelen reveals auto-regulation and high-temperature adaption of probable two-speed genome. International Journal of Molecular Sciences. 23(18), 10484. Doi: org/10.3390/ijms231810484
Liu QZ, Qu S, He GQ, Wei JK, Dong CH*. 2022. Mating-type genes play an important role in fruiting body development in Morchella sextelata. J Fungi (Basel). 2022, 8, 564.
Yang Y, Meng GL, Ni SJ, Zhang HF, Dong CH*. 2022. Genomic analysis of Stropharia rugosoannulata reveals its nutritional strategy and application potential in bioremediation. J Fungi (Basel). 8, 162. doi.org/10.3390/jof8020162.
Li X, Wang F, Xu Y, Liu G, Dong CH*. 2021. Cysteine-rich hydrophobin gene family: Genome wide analysis, phylogeny and transcript profiling in Cordyceps militaris. International Journal of Molecular Sciences. 22(2): 643. doi: 10.3390/ijms22020643.
Liu Q, Xu YY, Zhang XL, Li K, Li X, Wang F, Xu FX, Dong CH*. 2021. Infection process and genome assembly provide insights into the pathogenic mechanism of destructive mycoparasite Calcarisporium cordycipiticola with host specificity. J Fungi (Basel). 7(11):918. doi: 10.3390/jof7110918. (2021.10.28)
Li X, Wang F, Liu MQ, Dong CH*. 2021. Hydrophobin CmHYD1 is involved in conidiation, infection and primordium formation, and regulated by GATA transcription factor CmAreA in edible fungus, Cordyceps militaris. J Fungi (Basel). 7(8):674. doi: 10.3390/jof7080674.
Liu QZ, He GQ, Wei JK, Dong CH*. 2021. Comparative transcriptome analysis of cells from different areas reveals ROS responsive mechanism at sclerotial initiation stage in Morchella importuna, Scientific Reports. 11, 9418.
Li SJ, Wang Q, Dong CH*. 2021. Distinguishing homokaryons and heterokaryons in medicinal polypore mushroom Wolfiporia cocos (Agaricomycetes) based on cultural and genetic characteristics. Frontiers in Microbiology. 11: 596715. doi: 10.3389/fmicb.2020.596715.
Yang Y, Li CL, Ni SJ, Zhang HF, Dong CH*. 2021. Ultrastructure and development of acanthocytes, specialized cells in Stropharia rugosoannulata, revealed by scanning electron microscopy (SEM) and cryo-SEM. Mycologia. 113(1): 65–77. doi: 10.1080/00275514.2020.1823184.
Zhang JJ, Wang F, Yang Y, Dong CH*. 2020. CmVVD is involved in fruiting body development and carotenoid production and the transcriptional linkage among three blue-light receptors in edible fungus Cordyceps militaris. Environmental Microbiology. 22(1), 466–482.
Li X, Liu Q, Li WJ, Li QP, Qian ZM, Liu XZ, Dong CH*. 2019. A breakthrough in the artificial cultivation of Chinese cordyceps on a large-scale and its impact on science, the economy and industry. Critical Reviews in Biotechnology. 39:181-191.
Li X, Wang F, Liu Q, Li QP, Qian ZM, Zhang XL, Li K, Li WJ, Dong CH*. 2019. Developmental transcriptomics of Chinese cordyceps reveals gene regulatory network and expression profiles of sexual development-related genes. BMC Genomics. 4;20(1):337. doi: 10.1186/s12864-019-5708-z.