姓名：金腾川
性别：男
学历：研究生、博士
职称：正高、研究员
工作单位：中国科学技术大学
教育情况：
2003 - 2008 美国伊利诺伊理工大学，分子生物化学和生物物理学博士
1998 - 2003 中国科学技术大学，生物学理学学士
1998 - 2003 中国科学技术大学，工商管理学士
工作经历：
2015 – 目前 特任研究员、博导，中国科学技术大学
2012 – 2014 研究员（Research Fellow）, 美国国立卫生研究院
2008 - 2012 博士后, 美国国立卫生研究院
主要研究方向：
1. 天然免疫系统的结构生物学基础
2. 病原体与宿主相互作用的分子机制
3. 炎症反应及自身免疫病的分子机理
4. 蛋白质工程和蛋白药物研发
5. 食物过敏
代表性著作
发表论文 (#第一作者, *通讯作者)
1. Zheng X, Luo S, Sun U, Han M, Liu J, Sun L, Zhang L, Ling P, Ding Y, Jin T, Liu Z, Weng J (2020). Asymptomatic patients and asymptomatic phases of Coronavirus Disease 2019 (COVID-19): a population-based surveillance study. National Science Review.
2. Li WY, Li Y, Chen YL, Hu JJ, Mengist HM, Liu GM, Jin T*, Cao MJ* (2020). Characterization and crystal structure of prolyl endopeptidase from abalone (Haliotis discus hannai). Food Chem. 333:127452.
3. Fan X, Wang Y, Guo F, Zhang Y, Jin T* (2020). Atomic-resolution structures of type I ribosome inactivating protein alpha-momorcharin with different substrate analogs. Int J Biol Macromol. S0141-8130(20)33812-5.
4. Li Y, Hu X, Tu Y, Wu T, Wang B, Ma H, Zeng W, Zhao D, Mengist HM, Kombe AJK, Zheng M, Xu Y*, Jin T* (2020). A low viral dose in COVID-19 patient: A case report. Frontiers in Public Health. doi: 10.3389/fpubh.2020.00339
5. Mengist HM, Fan X, Jin T* (2020). Designing of improved drugs for COVID-19: Crystal structure of SARS-CoV-2 main protease Mpro. Signal Transduct Target Ther. 9;5(1):67. doi: 10.1038/s41392-020-0178-y.
6. Ma H, Zeng W, He H, Zhao D, Jiang D, Zhou P, Cheng L, Li Y*, Ma X*, Jin T* (2020). Serum IgA, IgM, and IgG responses in COVID-19. Cell Mol Immunol. doi: 10.1038/s41423-020-0474-z.
7. Zeng W, Liu G, Ma H, Zhao D, Yang Y, Liu M, Mohammed A, Zhao C, Yang Y, Xie J, Ding C, Ma X, Weng J, Gao Y, He H*, Jin T* (2020). Biochemical characterization of SARS-CoV-2 nucleocapsid protein. Biochem Biophys Res Commun. 527(3):618-623. doi: 10.1016/j.bbrc.2020.04.136.
8. Xie J, Ding C, Li J, Wang Y, Guo H, Lu Z, Wang J, Zheng C, Jin T, Gao Y, He H (2020). Characteristics of Patients with Coronavirus Disease (COVID-19) Confirmed using an IgM-IgG Antibody Test. J Med Virol. doi: 10.1002/jmv.25930.
9. Zhang Y, Jin T (2020). Almond allergens: update and perspective on identification and characterization. J Sci Food Agric. doi: 10.1002/jsfa.10417.
10. Zhang Z, Jin T, Xie X, Ban X, Li C, Hong Y, Cheng L, Gu Z, Li Z (2019). Structure of maltotetraose-forming amylase from Pseudomonas saccharophila STB07 provides insights into its product specificity. Int J Biol Macromol. pii: S0141-8130(19)37071-0.
11. Samad A, Li Y, Zhang C, Chen F, Zeng W, Fan X, Jin T* (2019). X-ray crystal structure of putative transcription regulator lmo2088 from Listeria monocytogenes. Biochem Biophys Res Commun pii: S0006-291X(19)31922-9.
12. Zahid A, Li B, Kombe AJK, Jin T*, Tao J* (2019). Pharmacological Inhibitors of the NLRP3 Inflammasome. Front Immunol. 10:2538
13. Fan X, Jin T* (2019). Structures of RIG-I-Like Receptors and Insights into Viral RNA Sensing. Adv Exp Med Biol. 1172:157-188. Review.
14. Xia F, Li MS, Liu Q, Liu M, Yang Y, Cao MJ, Chen G, Jin T*, Liu GM* (2019). Crystal structure analysis and conformational epitope mutation of triosephosphate isomerase, a mud crab allergen. J Agric Food Chem 67(46):12918-12926.
15. Zeng W, Ma H, Fan W, Yang Y, Zhang C, Arnaud Kombe Kombe J, Fan X, Zhang Y, Dong Z, Shen Z, Zhou Y, Yang M*, Jin T*(2019). Structure determination of CAMP factor of Mobiluncus curtisii and insights into structural dynamics. Int J Biol Macromol. pii: S0141-8130 (19)37284-8
16. Chen F, Ma H, Li Y, Wang H, Samad A, Zhou J, Zhu L, Zhang Y, He J, Fan X*, Jin T* (2019). Screening of Nanobody Specific for Peanut Major Allergen Ara h 3 by Phage Display. J Agric Food Chem 67(40):11219-11229.
17. Li W, Ji Q, Wei Z, Chen YL, Zhang Z, Yin X, Aghmiuni SK, Liu M, Chen W, Shi L, Chen Q, Du X, Yu L, Cao MJ, Wang Z, Huang S, Jin T*, Wang Q* (2019). Biochemical characterization of G64W mutant of acidic beta-crystallin 4. Exp Eye Res 186:107712.
18. Che H, Zhang Y, Jiang S, Jin T, Lyu SC, Nadeau KC, McHugh T (2019). Almond (Prunus dulcis) allergen Pru du 8, the first member of a new family of food allergens. J Agric Food Chem 67(31):8626-8631.
19. Li Y, Zeng W, Li Y, Fan W, Ma H, Fan X, Jiang J, Brefo-Mensah E, Zhang Y, Yang M, Dong Z, Palmer M, Jin T* (2019). Structure determination of the CAMP factor of Streptococcus agalactiae with the aid of an MBP tag and insights into membrane-surface attachment. Acta Cryst D 75(Pt 8):772-781.
20. Xie X, Li Y, Ban X, Zhang Z, Gu Z, Li C, Hong Y, Cheng L, Jin T*, Li Z* (2019). Crystal structure of a maltooligosaccharide-forming amylase from Bacillus stearothermophilus STB04. Int J Biol Macromol 138:394-402.
21. Liu X, Zhao Y, Shi H, Zhang Y, Yin X, Liu M, Zhang H, He Y, Lu B, Jin T, Li F*. Human immunoglobulin G hinge regulates agonistic anti-CD40 immunostimulatory and antitumour activities through biophysical flexibility (2019). Nat Commun 10(1):4206.
22. Yang Y, Hu MJ, Jin T, Zhang YX, Liu GY, Li YB, Zhang ML, Cao MJ, Su WJ, Liu GM* (2019). A comprehensive analysis of the allergenicity and IgE epitopes of myosinogen allergens in Scylla paramamosain. Clin Exp Allergy 49(1):108-119.
23. Chen YL, Li WY, Hu JJ, Li Y, Liu GM, Jin T*, Cao MJ* (2019). Nucleus-translocated matrix metalloprotease 1 regulates innate immune response in Pacific abalone (Haliotis discus hannai). Fish Shellfish Immunol 84:290-298.
24. Yang Y, Liu GY, Yang H, Hu MJ, Cao MJ, Su WJ, Jin T*, Liu GM * (2019). Crystal structure determination of Scylla paramamosain arginine kinase, an allergen that may cause cross-reactivity among invertebrates. Food Chem 271:597-605.
25. Yin X, Li W, Ma H, Zeng W, Peng C, Li Y, Liu M, Chen Q, Zhou R, Jin T* (2019). Crystal structure and activation mechanism of DR3 death domain. FEBS J. 286(13):2593-2610.
26. Duan GF, Ye Y, Xu S, Tao W, Zhao S, Jin T, Nicoll RA, Shi YS*, Sheng N* (2018). Signal peptide represses GluK1 surface and synaptic trafficking through binding to amino-terminal domain. Nat Commun 9(1):4879.
27. Yang RQ, Chen YL, Chen F, Wang H, Zhang Q, Liu GM, Jin T*, Cao MJ* (2018). Purification, Characterization, and Crystal Structure of Parvalbumins, the Major Allergens in Mustelus griseus. J Agric Food Chem 66(30):8150-8159.
28. Yan LJ, Jin T, Chen YL, Zhan CL, Zhang LJ, Weng L, Liu GM, Cao MJ* (2018). Characterization of a recombinant matrix metalloproteinase-2 from sea cucumber (Stichopus japonicas) and its application to prepare bioactive collagen hydrolysate. Process Biochem 72:63-70.
29. Jin T*,＃, Brefo. E＃, Fan W, Zeng W, Li Y, Zhang YZ, Palmer M (2018). Crystal structure of the Streptococcus agalactiae CAMP factor provides insights into its membrane-permeabilizing activity. J Biol Chem 293(30):11867-11877.
30. Li Y, Huang Y, Cao X, Yin X, Jin X, Liu S, Jiang J, Jiang W, Xiao TS, Zhou R, Cai G, Hu B, Jin T* (2018). Functional and Structural Characterization of Zebrafish ASC. FEBS J 285(14):2691-2707.
31. Fang K, Li Y, Yin X, Samad A, Jin T* (2018). High-Level Prokaryotic Expression and Purification of Death Domain Superfamily with MBP Tag. Clin Lab. 64(4):467-475. doi: 10.7754/Clin.Lab.2017.170922.
32. Zhou K, Fan X, Li Y, Zhang C, Jin T* (2018). High-resolution crystal structure of Streptococcus agalactiae glyceraldehyde-3-phosphate dehydrogenase. Acta Crystallogr F Struct Biol Commun. 74(Pt 4):236-244. doi: 10.1107/S2053230X18003801.
33. Jin T*, Huang M, Jiang J, Smith P, Xiao TS* (2018). Crystal structure of human NLRP12 PYD domain and implication in homotypic interaction. PLoS One. 13(1): e0190547. doi: 10.1371/journal.pone.0190547.
34. Hu JJ, Chen YL, Duan XK, Jin T, Li Y, Zhang LJ, Liu GM, Cao MJ* (2018). Involvement of clip-domain serine protease in the anti-Vibrio immune response of abalone (Haliotis discus hannai)-Molecular cloning, characterization and functional analysis. Fish Shellfish Immunol 72:210-219.
35. Gong T, Yang Y, Jin T, Jiang W, Zhou R* (2018). Orchestration of NLRP3 Inflammasome Activation by Ion Fluxes. Trends Immunol 39(5):393-406.
36. Jin T*, Wang C, Zhang CY, Wang Y, Chen YW, Guo F, Howard A, Cao MJ, Fu TJ, McHugh TH, Zhang YZ* (2017). Crystal Structure of Cocosin, A Potential Food Allergen from Coconut ?(Cocos nucifera). J Agric Food Chem 65(34): 7560-7568.
37. Jiang H, He H, Chen Y, Huang W, Cheng J, Ye J, Wang A, Tao J, Wang C, Liu Q, Jin T, Jiang W, Deng X, Zhou R* (2017). Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders. J Exp Med 214(11): 3219-3238.
38. Jin T*, Chuenchor W, Jiang J, Cheng J, Li YJ, Fang K, Huang M, Smith P, Xiao TS* (2017). Design of an expression system to enhance MBP-mediated crystallization. Sci Rep 7:40991-40997.
39. Balinsky CA, Schmeisser H, Wells AI, Ganesan S, Jin T, Singh K, Zoon KC. IRAV (FLJ11286), an Interferon Stimulated Gene with Antiviral Activity Against Dengue Virus, Interacts with MOV10 (2016). J Virol. pii: e01606-16.
40. Cao X#, Li YJ#*, Jin X, Li YL, Guo F, Jin T* (2017). Molecular Mechanism of Divalent-Metal-Induced Activation of NS3 Helicase and Insights into Zika Virus Inhibitor Design. Nucleic Acids Res 44(21): 10505-10514.
41. Zhang C, Feng T, Cheng J, Li YJ, Yin X, Zeng W, Jin X, Li YL, Guo F and Jin T* (2017). Structure of the NS5 methyltransferase from Zika virus and implications in inhibitor design. Biochem Biophs Res Commun 492(4):624-630.
42. Li YJ, Li YL, Cao X, Jin X, and Jin T* (2017). Pattern recognition receptors in zebrafish provide functional and evolutionary insight into innate immune signaling pathways. Cell Mol Immunol 14(1):80-89.
43. Bertheloot D, Naumovski AL, Langhoff P, Horvath GL, Jin T, Xiao TS, Garbi N, Agrawal S, Kolbeck R, Latz E (2016). RAGE Enhances TLR Responses through Binding and Internalization of RNA. J Immunol 197(10): 4118-4126.
44. Zhao Y#, Cai Q#, Jin T, Zhang L, Fei D, Liu G, and Cao M (2017). Effect of Maillard reaction on the structural and immunological properties of recombinant silver carp parvalbumin. LWT Food Sci Technol 75: 25-33.
45. Herzner A#, Hagmann CA#, Goldeck M, Keßels S, Kübler K, Wittmann S, Gramberg T, Andreeva L, Hopfner K, Mertens C, Zillinger T, Jin T, Xiao TS, Bartok E, Coch C, Ackermann D, Hornung V, Ludwig J, Barchet W, Hartmann G* and Schlee M* (2015). Sequence-specific activation of cGAS by Y-form DNA structures as found in primary HIV-1 cDNA. Nat Immunology 16(10): 1025-33.
46. Jin T* and Xiao TS* (2015). Activation and assembly of the inflammasomes through conserved protein domain families. Apoptosis 20(2): 151-6. (*co-corresponding author, review)
47. Jin T*, Wang Y, Chen YW, Albillos SM, Kothary MH, Fu TJ, Tankersley B, McHugh TH, Zhang YZ* (2014). Isolation and characterization of Korean pine (Pinus koraiensis) convicilin. Plant Physiol Biochem 80: 97-104. (*co-corresponding author)
48. Chuenchor W#, Jin T#, Ravilious G, Xiao TS* (2014). Structures of pattern recognition receptors reveal molecular mechanisms of autoinhibition, ligand recognition and oligomerization. Curr Opin Immunol 26:14-20. (#co-first author, invited review).
49. Jin T*, Wang Y, Chen YW, Fu TJ, Kothary MH, McHugh TH, Zhang YZ* (2013). Crystal structure of the Korean pine (Pinus koraiensis) 7S seed storage protein with copper ligand. J Agric Food Chem 62(1): 222-228. (*co-corresponding author)
50. Jakobsen MR, Andersen A, Berg RK, Bak RO, Jin T, Hansen K, Jen SB, Østergaard LJ, Towers GJ, Fitzgerald KA, Xiao TS, Mikkelsen JG, Mogensen TH, Paludan SR (2013). IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication. Proc Natl Acad Sci U S A 110(48): E4571-4580.
51. Sirois CM#, Jin T#, Miller AL, Nakamura H, Horvath GL, Mian A, Jiang J, Schrum J, Brewah Y, Tian J, Chang C, Schowdhury PS, Sims GP, Kolbeck R, Coyle AJ, Humbles AA, Xiao TS*, Latz E * (2013). RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA. J Exp Med 210: 2447-2463. (#co-first author). Highlighted in the November 2013 issue of Nature Structural & Molecular Biology.
52. Jin T, Huang Mo, Smith P, Jiang J and Xiao TS (2013). Crystal structure of the caspase recruitment domain from a zebrafish guanylate-binding protein. Acta Crystallogr Sect F Struct Biol Cryst Commun 69: 855-860.
53. Jin T, Curry J, Smith P, Jiang J, and Xiao TS (2013). Structure of the NLRP1 caspase recruitment domain reveals potential mechanisms of association with Caspase-1. Proteins 81(7): 1266-70.
54. Jin T, Perry A, Smith P, Jiang J and Xiao TS (2013). Structure of the AIM2 pyrin domain provides insights into the mechanisms of AIM2 autoinhibition and inflammasome assembly. J Biol Chem 288: 13225-13235.
55. Jin T, Huang Mo, Smith P, Jiang J and Xiao TS (2013). Potential mechanisms for CARD8 association with procaspase-1 revealed by the crystal structure of the CARD8 caspase recruitment domain. Acta Crystallogr Sect F Struct Biol Cryst Commun 69: 482-486 (cover)
56. Conlon J#, Burdette DL#, Sharma S, Bhat N, Jiang Z, Jin T, Xiao TS, Vogel S, Vance RE and Fitzgerald KA (2013). Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5,6-Dimethylxanthenone-4-Acetic Acid. J Immunol 190: 5216-5225.
57. Jin T, Guo F, Wang Y, Zhang YZ (2013). High-resolution crystal structure of human Dim2/TXNL4B. Acta Crystallogr Sect F Struct Biol Cryst Commun 69: 223-227.
58. Jin T, Perry A, Jiang J, Smith P, Curry JA, Unterholzner L, Jiang Z, Horvath G, Rathinam V, Hornung V, Johnstone RW, Latz E, Bowie AG, Fitzgerald KA, Xiao TS (2012). Structures of The HIN domain:DNA complexes reveal ligand binding and activation mechanisms of The AIM2 inflammasome and IFI16. Immunity 36(4): 561-571
59. Unterholzner L, Keating SE, Baran M, Horan KA, Jensen SB, Sharma S, Sirois CM, Jin T, Latz E, Xiao TS, Fitzgerald KA, Paludan SR, Bowie AG (2010). IFI16 is an innate immune sensor for intracellular DNA. Nat Immunol 11: 997-1004.
60. Jin T, Guo F, Chen YW, Howard A, Zhang YZ (2009). Crystal structure of Ara h 3, a major allergen in peanut. Mol Immunol 46: 1796-1804.
61. Jin T, Albillos SM, Guo F, Howard A, Fu TJ, Kothary MH, Zhang YZ (2009). Crystal structure of prunin-1, a major component of the almond (Prunus dulcis) allergen amandin. J Agric Food Chem 57: 8643-8651.
62. Jin T, Chen YW, Howard A, Zhang YZ (2008). Purification, crystallization and initial crystallographic characterization of the Ginkgo biloba 11S seed globulin ginnacin. Acta Crystallogr Sect F Struct Biol Cryst Commun 64: 641-644.
63. Jin T, Albillos SM, Chen YW, Kothary MH, Fu TJ, Zhang YZ (2008). Purification and characterization of the 7S vicilin from Korean pine (Pinus koraiensis). J Agric Food Chem 56: 8159-8165.
64. Albillos SM, Jin T, Howard A, Zhang Y, Kothary MH, Fu TJ (2008). Purification, crystallization and preliminary X-ray characterization of prunin-1, a major component of the almond (Prunus dulcis) allergen amandin. J Agric Food Chem 56: 5352-5358.
65. Jin T, Kim S, Guo F, Howard A, Zhang YZ (2007). Purification and crystallization of recombinant human TNF-like ligand TL1A. Cytokine 40: 115-122.
66. Wu XZ, Wei HM, Zheng XD, Jin T, Tian ZG (2007). Induction and mechanism study of anti-melanoma immune response by M. tuberculosis Ag85B. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 23(1): 36-8.
67. Jin T, Howard A, Zhang YZ (2007). Purification, crystallization and initial crystallographic characterization of peanut major allergen Ara h 3. Acta Crystallogr Sect F Struct Biol Cryst Commun 63: 848-851.
68. Jin T, Guo F, Serebriiskii IG, Howard A, Zhang YZ (2007). A 1.55 A resolution X-ray crystal structure of HEF2/ERH and insights into its transcriptional and cell-cycle interaction networks. Proteins 68: 427-437.
69. Jin T, Guo F, Kim S, Howard A, Zhang YZ (2007). X-ray crystal structure of TNF ligand family member TL1A at 2.1A. Biochem Biophys Res Commun 364: 1-6.
70. Jin T, Fu TJ, Kothary MH, Howard A, Zhang YZ (2007). Crystallization and initial crystallographic characterization of a vicilin-type seed storage protein from Pinus koraiensis. Acta Crystallogr Sect F Struct Biol Cryst Commun 63: 1041-1043.
71. Guo F, Jin T, Howard A, Zhang YZ (2007). Purification, crystallization and initial crystallographic characterization of brazil-nut allergen Ber e 2. Acta Crystallogr Sect F Struct Biol Cryst Commun 63: 976-979.
72. Wu X, Wei H, Jin T, Tian Z (2007). Ag85B induces the antitumor immunity effect. China J. Lepr Skin Dis 23(1): 6-9.
73. Jin T, Guo F, Wang Y, Zhang YZ (2006). Identification of human dim1 as a peptidase with autocleavage activity. Chem Biol Drug Des 68: 266-272.
74. Jin T, Howard AJ, Golemis EA, Wang Y, Zhang YZ (2005). Overproduction, purification, crystallization and preliminary X-ray diffraction studies of the human spliceosomal protein TXNL4B. Acta Crystallogr Sect F Struct Biol Cryst Commun 61: 282-284.
75. Jin T, Howard A, Golemis EA, Wang Y, Zhang YZ (2005). Overproduction, purification, crystallization and preliminary X-ray diffraction studies of the human transcription repressor ERH. Acta Crystallogr Sect F Struct Biol Cryst Commun 61: 531-533.
76.Jin T, Zhang RJ, Wei HM, He HH, Tian ZG (2004). The high-concentration refolding, purification and bioactivity assay of recombinant human interleukin-18. Chinese Journal of Biomedical Pharmaceutics 25: 67-71.
