姓名：李灏
性别：男
学历：博士
职称：副教授
工作单位：北京化工大学生命科学与技术学院
教育情况：
1995-1999 山东大学，微生物学专业，理学学士
1999-2002 山东大学，微生物学专业，理学硕士
2002-2005 中国海洋大学，海洋生物学专业，理学博士
工作经历：
2005-2008 军事医学科学院放射与辐射医学研究所，北京蛋白质组研究中心，博士后研究工作
2008至今 北京化工大学生命科学与技术学院
主要研究方向：
1、发酵过程中产物胁迫问题（胁迫机制、如何提高胁迫耐受性、膜在响应或耐受胁迫中的作用等）；
2、生物发酵过程中染菌问题（利用生物法防控杂菌污染、杂菌污染对酿酒酵母细胞代谢及菌群关系等的影响）；
3、代谢组学及其应用；
4、核酸适配体筛选及其应用。
代表性著作：
1．Xiaoru Zhang, Yaxian Zhang, Hao Li*. Regulation of trehalose, a typical stress protectant, on central metabolisms, cell growth and division of Saccharomyces cerevisiae CEN.PK113-7D. Food Microbiology, 2020, 89: 103459. (*通讯作者)
2．Chuchu Wang, Xiaoyan Du, Tiantian Xie, Hao Li*. Label- and modification-free-based in situ selection of bovine serum albumin specific aptamer. Journal of Separation Science, 2019 42 (23): 3571-3578. (*通讯作者)
3．Ming Li, Hongwei Hu, Ze Chen, Yaxian Zhang, Hao Li*. Using drug-loaded pH-responsive poly(4-vinylpyridine) microspheres as a new strategy for intelligent controlling of Lactobacillus plantarum contamination in bioethanol fermentation. World Journal of Microbiology and Biotechnology, 2018, 34 (10): 146. (*通讯作者)
4．Ze Chen, Zhou Zheng, Fenglian Wang, Yuanpu Niu, Jinlai Miao*, Hao Li*. Intracellular metabolic changes of Rhodococcus sp. LH during the biodegradation of diesel oil. Marine Biotechnology, 2018, 20 (6): 803-812. (*通讯作者)
5．Zhihua Ji, Yaxian Zhang, Juan Tian, Fengbang Wang, Maoyong Song*, Hao Li*. Oxidative stress and cytotoxicity induced by tetrachlorobisphenol A in Saccharomyces cerevisiae cells. Ecotoxicology and Environmental Safety, 2018, 161: 1-7. (*通讯作者)
6．Lihui Wang, Chuchu Wang, Hao Li*. Selection of DNA aptamers and establishment of an effective aptasensor for highly sensitive detection of cefquinome residues in milk. Analyst, 2018, 143: 3202-3208. (*通讯作者)
7．Juan Tian, Zhihua Ji, Fengbang Wang, Maoyong Song*, Hao Li*. The toxic effects of Tetrachlorobisphenol A in Saccharomyces cerevisiae cells via metabolic interference. Scientific Reports, 2017, 7 (1): 2655. (*通讯作者)
8．Ye Duan, Lihui Wang, Zhiqiang Gao, Huishan Wang, Hexiao Zhang*, Hao Li*. An aptamer-based effective method for highly sensitive detection of chloramphenicol residues in animal-sourced food using real-time fluorescent quantitative PCR. Talanta, 2017, 165: 671-676. (*通讯作者)
9．Bo Liu, Huaqing Liu, Yunxiao Zhang, Hao Li*. Control of Lactobacillus plantarum contamination in bioethanol fermentation by adding plantaricins. International Journal of Agriculture and Biology, 2017, 19: 171-176. (*通讯作者)
10．Juan Tian, Shuxian Zhang, Hao Li*. Changes in intracellular metabolisms underlying the adaptation of Saccharomyces cerevisiae strains to ethanol stress. Annals of Microbiology, 2017, 67 (2): 195-202. (*通讯作者)
11．Ze Chen, Zhou Zheng, Chenfeng Yi, Fenglian Wang, Yuanpu Niu, Hao Li*. Intracellular metabolic changes of Saccharomyces cerevisiae and promotion to ethanol tolerance during the bioethanol fermentation process. RSC Advances, 2016, 6: 105046-105055. (*通讯作者)
12．Yuanpu Niu, Xianghua Lin, Shijun Dong, Qipeng Yuan, Hao Li*. Indentation with atomic force microscope, Saccharomyces cerevisiae cell gains elasticity under ethanol stress. The International Journal of Biochemistry & Cell Biology, 2016, 79: 337-344. (*通讯作者)
13．Yanfeng Wang, Juan Tian, Zhihua Ji, Maoyong Song, Hao Li*. Intracellular metabolic changes of Clostridium acetobutylicum and promotion to butanol tolerance during biobutanol fermentation. The International Journal of Biochemistry & Cell Biology, 2016, 78: 297-306. (*通讯作者)
14．Ye Duan, Zhiqiang Gao, Lihui Wang, Huishan Wang, Hexiao Zhang*, Hao Li*. Selection and identification of chloramphenicol specific DNA aptamers by Mag-SELEX. Applied Biochemistry and Biotechnology, 2016, 180 (8): 1644-1656. (*通讯作者)
15．Chenfeng Yi, Fenglian Wang, Shijun Dong, Hao Li*. Changes of trehalose content and expression of relative genes during the bioethanol fermentation by Saccharomyces cerevisiae. Canadian Journal of Microbiology, 2016, 62 (10): 827-835. (*通讯作者)
16．Shijun Dong, Chenfeng Yi, Hao Li*. Changes of Saccharomyces cerevisiae cell membrane components and promotion to ethanol tolerance during the bioethanol fermentation. The International Journal of Biochemistry & Cell Biology, 2015, 69: 196-203. (*通讯作者)
17．Shijun Dong, Xianghua Lin, Hao Li*. Regulation of Lactobacillus plantarum contamination on the carbohydrate and energy related metabolisms of Saccharomyces cerevisiae during bioethanol fermentation. The International Journal of Biochemistry & Cell Biology, 2015, 68: 33-41. (*通讯作者)
18．Xianghua Lin, Pei Han, Shijun Dong, Hao Li*. Preparation and application of bacteriophage-loaded chitosan microspheres for controlling Lactobacillus plantarum contamination in bioethanol fermentation. RSC Advances, 2015, 5: 69886-69893. (*通讯作者)
19．Yanfeng Wang, Shuxian Zhang, Huaqing Liu, Lei Zhang, Chenfeng Yi, Hao Li*. Changes and roles of membrane compositions in the adaptation of Saccharomyces cerevisiae to ethanol. Journal of Basic Microbiology, 2015, 55 (12): 1417-1426. (*通讯作者)
20．Fengxia Cui, Ruimin Zhang, Huaqing Liu, Yanfeng Wang, Hao Li*. Metabolic responses to Lactobacillus plantarum contamination or bacteriophage treatment in Saccharomyces cerevisiae using a GC-MS-based metabolomics approach. World Journal of Microbiology & Biotechnology, 2015, 31 (12): 2003-2013. (*通讯作者)
21．Fengxia Cui, Huaqing Liu, Zhongmei Zou*, Hao Li*. Metabolic responses to water deprivation in C57BL/6J mice using a proton nuclear magnetic resonance-based metabonomics approach. RSC Advances, 2015, 5: 80142-80149. (*通讯作者)
22．Ribang Wu, CuiLing Wu, Dan Liu, Xinghao Yang, Jiafeng Huang, Jiang Zhang, Binqiang Liao, Hailun He*, Hao Li*. Overview of antioxidant peptides derived from marine resources: the sources, characteristic, purification, and evaluation methods. Applied Biochemistry and Biotechnology, 2015, 176 (7): 1815-1833. (*通讯作者)
23．Dan Liu, Xinghao Yang, Jiafeng Huang, Ribang Wu, Cuiling Wu, Hailun He*, Hao Li*. In situ demonstration and characteristic analysis of the protease components from marine bacteria using substrate immersing zymography. Applied Biochemistry and Biotechnology, 2015, 175 (1): 489-501. (*通讯作者)
24．Manli Ma, Pei Han, Ruimin Zhang, Hao Li*. Ultrastructural changes of Saccharomyces cerevisiae in response to ethanol stress. Canadian Journal of Microbiology, 2013, 59 (9): 589-597. (*通讯作者)
25. 段烨, 高志强, 王慧珊, 张鹤晓, 李灏*. 核酸适体技术及其在兽药残留检测中的应用. 中国兽医杂志, 2015, 51 (11): 75-78. (*通讯作者)
26. 方华, 李灏*. 海藻糖与热激蛋白在酿酒酵母耐受乙醇胁迫中的作用, 中国生物工程杂志, 2014, 34（6）: 84-89. (*通讯作者)
27. 刘华擎, 李灏*. 生物质能源发酵中染菌及防控的研究进展, 中国生物工程杂志, 2013, 33 （12）: 114-120. (*通讯作者)
28. Xianmei Hu, Hao Li*, Pingwah Tang, Jie Sun, Qipeng Yuan, Chunfang Li. GC-MS-based metabolomics study of the responses to arachidonic acid in Blakeslea trispora. Fungal Genetics and Biology, 2013, 57: 33-41. (*共同第一作者)
29. Hao Li, Manli Ma, Sha Luo, Ruimin Zhang, Pei Han, Wei Hu. Metabolic responses to ethanol in Saccharomyces cerevisiae using a gas chromatography tandem spectrometry-based metabolomics approach. The International Journal of Biochemistry & Cell Biology, 2012, 44 (7): 1087-1096.
30. Hao Li, Manli Ma, Huijun Xie, Jian Kong. Biosafety evaluation of bacteriophages for treatment of diarrhea due to intestinal pathogen Escherichia coli 3-2 infection of chickens. World Journal of Microbiology and Biotechnology, 2012, 28: 1-6.
31. Hao Li, Lan Wang, Xianzhong Yan, Qijun Liu, Chaohui Yu, Handong Wei, Youming Li, Xuemin Zhang, Fuchu He, Ying Jiang. A proton nuclear magnetic resonance metabonomics approach for biomarker discovery in nonalcoholic fatty liver disease. Journal of Proteome Research, 2011, 10 (6): 2797-2806.
