姓名：张梁
性别：男
学历：博士
职称：副教授
工作单位：安徽农业大学茶与食品科技学院
教育情况：
2007-2010 北京大学，生药学博士
2004-2007 上海中医药大学，药剂学硕士
2000-2004 江西中医药大学，药学学士
工作经历：
2011.1-至今 安徽农业大学，茶与食品科技学院，副教授
2013.11-2014.11 University of Massachusetts Amherst, Food Science, Visiting Scholar.
所受奖项：
2015年第四届中国茶叶学会青年科技奖；
中国科协2016-2018“青年人才托举工程”人才项目；
2016年第八届安徽省自然科学优秀学术论文二等奖；
2018年安徽省创新争先奖；
主要研究方向：
茶叶化学、分析化学、质谱分析、代谢组学；
代表性著作：
1. Bo Chen†, Jie Zhou†, Qilu Meng, Yang Zhang, Shihua Zhang, Liang Zhang*. Comparative analysis of fecal phenolic content between normal and obese rats after oral administration of tea polyphenols. Food & Function, 2018,9, 4858-4864 中科院1区.
2. Xuemei Guo†, Piaopiao Long†, Qilu Meng, Chi-Tang Ho, Liang Zhang*. An emerging strategy for evaluating the grades of Keemun black tea by combinatory liquid chromatography-Orbitrap mass spectrometry-based untargeted metabolomics and inhibition effects on α-glucosidase and α-amylase. Food Chemistry, 2018, 246:74-81. 中科院1区
3. Yunru Peng†, Qilu Meng†, Jie Zhou, Bo Chen, Junjun Xi, Piaopiao Long, Liang Zhang*, Ruyan Hou*. Nanoemulsion delivery system of tea polyphenols enhanced the bioavailability of catechins in rats. Food Chemistry, 2018, 242:527-532. 中科院1区. 被引用次数：1
4. Jie Zhou, You Wu, Piaopiao Long, Chi-Tang Ho, Yijun Wang, ZhipengKan, Luting Cao, Liang Zhang*, Xiaochun Wan*. LC-MS-based metabolomics reveals the chemical changes of polyphenols during high-temperature roasting of large-leaf yellow tea. Journal of Agricultural and Food Chemistry, 2019, Accepted. 中科院1区
5. Shihua Zhang†, Liang Zhang†, Yijun Wang†, Jian Yang, Mingzhi Liao, Shoudong Bi, Zhongwen Xie, Chi-Tang Ho, Xiaochun Wan. TBC2target: A Resource of Predicted Target Genes of Tea Bioactive Compounds. Frontiers in Plant Science, 2018, 9, 211. 中科院2区.
6. Jie Zhou†, Liang Zhang†, Qilu Meng, Yijun Wang, Piaopiao Long, Chi-Tang Ho, Chuanjian Cui, Luting Cao, Daxiang Li*, Xiaochun Wan*. Roasting process improves the hypoglycemic effect of large-leaf yellow tea infusion by enhancing levels of the epimerized catechins that inhibit α-glucosidase. Food & Function, 2018,9, 5162-5168 . 中科院1区
7. Qilu Meng†, Piaopiao Long†, Jie Zhou, Chi-Tang Ho, Xiaohui Zou, Bo Chen, Liang Zhang*. Improved absorption of β-carotene by encapsulation in an oil-in-water nanoemulsion containing tea polyphenols in the aqueous phase. Food Research International, 2018, doi:10.1016/j.foodres.2018.09.004. 中科院2区
8. Shihua Zhang, Liang Zhang, Yuling Tai, Xuewen Wang, chi-tang Ho, and xiao-chun wan. Gene Discovery of Characteristic Metabolic Pathways in the Tea Plant (Camellia sinensis) Using ‘Omics’-based Network Approaches: A Future Perspective. Frontiers in Plant Science, 2018, doi: 10.3389/fpls.2018.00480. 中科院2区.
9. Shahid A Junejo, Liang Zhang, Liping Yang, Naifu Wang, Yibin Zhou, Yuesheng Xia, Haisong Wang. Anti‐hyperlipidemic and hepatoprotective properties of wheat bran with different particle sizesJournal of the Science of Food and Agriculture, 2018, doi /10.1002/jsfa.9397.
10. Cui, C., Zong, J., Sun, Y., Zhang, L., Ho, C. T., Wan, X., & Hou, R. (2018). Triterpenoid saponins from the genus Camellia: structures, biological activities, and molecular simulation for structure–activity relationship. Food & function, 9(6), 3069-3091.
11. Liang Zhang†, Yuling Tai†, Yijun Wang, Qilu Meng, Yunqiu Yang, Shihua Zhang, Hua Yang, Zhengzhu Zhang, Daxiang Li, & Xiaochun Wan*. The proposed biosynthesis of procyanidins by the comparative chemical analysis of fve Camellia species using LC-MS. Scientific Reports, 2017, 7:e46131. 中科院3区. 被引用次数：1
12. Luting Cao†, Xuemei Guo†, Guangjin Liu, Yuelin Song, Chi-Tang Ho, Ruyan Hou, Liang Zhang*, Xiaochun Wan*. A comparative analysis for the volatile compounds of various Chinese dark teas using combinatory metabolomics and fungal solid-state fermentation. Journal of Food and Drug Analysis, 2018, 26, 112-123. 中科院4区. 被引用次数：2
13. Bo Chen†, Piaopiao Long†, Yue Sun, Qilu Meng, Xingxun Liu, Huanhuan Cui, Qingya Lv, Liang Zhang*. The chemical profiling of loquat leaf extract by HPLC-DAD-ESI-MS and its effects on hyperlipidemia and hyperglycemia in rats induced by a high-fat and fructose diet. Food & Function, 2017, 8, 687-694. 中科院1区. 被引用次数：2
14. Liang Zhang*, Yijun Wang, Daxiang Li, Chi-Tang Ho, Junsong Li, Xiaochun Wan. The absorption, distribution, metabolism and excretion of procyanidins. Food & Function, 2016, 7, 1273-1281. 中科院1区. 被引用次数：30
15. Shihua Zhang, Hongdong Xuan, Liang Zhang, Sicong Fu, Yijun Wang, Hua Yang, Yuling Tai, Youhong Song, Jinsong Zhang, Chi-Tang Ho, Shaowen Li and Xiaochun Wan (2016). TBC2health: a database of experimentally validated health-beneficial effects of tea bioactive compounds. Briefings in Bioinformatics, 2026,18(5), 830-836. 中科院1区. 被引用次数：4
16. Tian-Qi Rui, Liang Zhang, Hong-Zhi Qiao, Ping Huang, Shuai Qian, Jun-Song Li, Zhi-Peng Chen, Ting-Ming Fu, Liu-Qing Di, Baochang Cai. Preparation and Physicochemical and Pharmacokinetic Characterization of Ginkgo Lactone Nanosuspensions for Antiplatelet Aggregation. Journal of Pharmaceutical Sciences, 2016, 105(1), 242–249. 被引用次数：7
17. Jianfa Zong, Dongxu Wang, Weiting Jiao, Liang Zhang, Guanhu Bao, Chi-Tang Ho, Ruyan Hou* and Xiaochun Wan*. Oleiferasaponin C6 from the seeds of Camellia oleifera Abel.: a novel compound inhibits proliferation through inducing cell-cycle arrest and apoptosis on human cancer cell lines in vitro, RSC Advances, 2016, 6, 91386-91393. 被引用次数：6
18. Liang Zhang, Yuhui Han, Liwei Xu, Yuhong Liang, Xin Chen, Junsong Li, Xiaochun Wan. The effects of co-administration of butter on the absorption, metabolism and excretion of catechins in rats after oral administration of tea polyphenols. Food & Function, 2015,6(7), 2249-2256. 2.791 IF.中科院1区. 被引用次数：5
19. Liang Zhang, Yuhui Han, Jinjun Shan, Yuhong Liang,, Liwei Xu, Shihua Zhang, Jun-Song Li, Xiaochun Wan. Simultaneous determination of seven catechins in rat plasma by ultra-high performance liquid chromatography tandem mass spectrometry and its application to a pharmacokinetics study, Analytical Methods, 2015, 7(22), 9415-9420. 1.821 IF.中科院3区. 被引用次数：3
20. Liwei Xu., Yuhong Liang, Xin Chen, Bo Chen, Yuhui Han, Liang Zhang*. (2015). Hyperlipidemia affects the absorption, distribution and excretion of seven catechins of rats following oral administration of tea polyphenols. RSC Advances, 2015, 5 (119), 97988--97994. 3.840 IF. 中科院3区. 被引用次数：6
21. Jun-Hui Yang†, Liang Zhang†, Jun-Song Li, Li-Hua Chen, Qin Zheng, Ting Chen, Zhi-Peng Chen, Ting-Ming Fu, Liu-Qing Di. Enhanced oral bioavailability and prophylactic effects on oxidative stress and hepatic damage of an oil solution containing a rosmarinic acid-phospholipid complex. Journal of Functional Food, 2015,19:63–73. 3.574 IF. 中科院1区. 被引用次数：4
22. Xiao-Cui Qian†, Liang Zhang†, Yi Tao, Ping Huang, Jun-Song Li, Chuan Chai, Wen Li, Liu-Qing Di, Bao-Chang Cai, Simultaneous determination of ten alkaloids of crude and wine-processed Rhizoma Coptidis aqueous extracts in rat plasma by UHPLC–ESI–MS/MS and its application to a comparative pharmacokinetic study, Journal of Pharmaceutical and Biomedical Analysis, 2015,105:64-73. 2.979 IF. 被引用次数：25
23. Zong Jianfa, Wang Ruilong, Bao Guanhu, Ling Tiejun, Zhang Liang, Zhang Xinfu, & Hou Ruyan. Novel triterpenoid saponins from residual seed cake of Camellia oleifera Abel. show anti-proliferative activity against tumor cells. Fitoterapia, 2015, 104, 7-13. 4 区2.345 IF被引用次数：31
24. 张宁, 宛晓春, 周杰, 张梁*. 泾渭茯茶化学成分 HPLC 指纹图谱的研究. 西北农林科技大学学报: 自然科学版, 2015, 43(9): 103-108.
25. Liang Zhang, Wei-Wei Deng, Xiao-Chun Wan. Advantage of LC-MS metabolomics to identify marker compounds of two types of Chinese dark teas after different postfermentation processes, Food Science and Biotechnology, 2014, 23(2): 355-360. 0.653 IF. 中科院4区. 被引用次数：6
26. Weinan Wang†, Liang Zhang†, Shu Wang, Shepo Shi, Yong Jiang, Ning Li, Pengfei Tu, 8-C N-ethyl-2-pyrrolidinone substituted flavan-3-ols as the marker compounds of Chinese dark teas formed in the post-fermentation process provide significant antioxidative activity, Food Chemistry,2014, 152(1):539-545. 3.391 IF. 中科院1区. 被引用次数：27
27. Ping Huang†, Liang Zhang†, Chuan Chai, Xiaocui Qian, Wen Li, Jun-Song Li, Liu-Qing Di, Bao-Chang Cai, Effects of Food and Gender on the Pharmacokinetics of Ginkgolides A, B, C and Bilobalide in Rats after Oral Dosing with Ginkgo Terpene Lactones extract, Journal of Pharmaceutical and Biomedical Analysis, 2014,100:138-144. 2.979 IF. 中科院2区. 被引用次数：13
28. Jie Zhou†, Liang Zhang†, Jingsong Zhang, Xiaochun Wan. Aqueous extract of post-fermented tea reverts the hepatic steatosis of hyperlipidemia rat by regulating the lipogenic genes expression and hepatic fatty acid composition, BMC Complementary and Alternative Medicine 2014, 14:263-270. 2区 2.02 IF. 被引用次数：9
29. Lin Feng, Ming-Jun Gao, Ru-Yan Houa, Xiao-Yi Hu, Liang Zhang, Xiao-Chun Wan, Shu Wei. Determination of quality constituents in the young leaves of albino tea cultivars. Food Chemistry. 2014, 155:98-104. 中科院1区. 被引用次数：39
30. Jin Liang, Lin Cao, Liang Zhang, Xiao-Chun Wan. Preparation, characterization, and in vitro antitumor activity of folate conjugated chitosan coated EGCG nanoparticles. 2014, 23(2): 569-575. 被引用次数：18
31. 张梁*, 韩煜晖, 秦金花. 发酵茶叶水浸出物对PC12神经细胞保护作用. 食品研究与开发, 2014, 35(4):1-4.
32. Liang Zhang, Zheng-Zhu Zhang, Yi-bin Zhou, Tie-jun Ling; Xiao-Chun Wan. Chinese dark teas: postfermentation, chemistry and biological activities, Food research international, 2013, 53(2):600-607. 2.818 IF. 中科院2区. 被引用次数：63
33. Ning Li, Liang Zhang, Ke-Wu Zeng, Yuan Zhou, Jia-Yu Zhang, Yan-Yun Che, Peng-Fei Tu. Cytotoxic steroidal saponins from Ophiopogon japonicas. Steroids, 2013, 78(1):1-7. 被引用次数：36
34. 张梁, 屠鹏飞. 普洱茶中黄酮类化学成分研究. 中国中药杂志, 2013, 38(9):26-29. 被引用次数：4
35. 张梁*，农林院校《天然产物化学》教学内容和方法改革探讨. 安徽农学通报, 2013, 19(05):114-116.
36. 张梁*, 周杰, 朱蔚, 张世华. HPLC-DAD-ESI-MSn和GC-MS比较陈皮橘皮和霉变橘皮中的化学成分. 食品与发酵工业, 2013, 39(4):192-199. 被引用次数：4
37. 朱圣洁, 桑八一, 张正竹, 张梁*. 绿茶糖苷类香气前体的GC-MS和HPLC-ESI-MSn分析. 天然产物研究与开发, 2013, 25(7): 922-927.
38. 张梁*, 周杰, 秦金花. 多种茶叶废料中多酚类成分和咖啡碱的含量测定. 食品科学, 2013, 34(20):113-116. 被引用次数：2
39. 盛 俊, 张 梁*, 张正竹. 普洱茶中咖啡碱在小鼠体内的吸收情况研究. 安徽农业大学学报, 2013,40(6):912-916.
40. Liang Zhang, Zheng-Zhu Zhang, Ya-Ning Lu, Jing-Song Zhang. Intestinal transport of L-theanine from green tea and effects on human healthcares. In: Preedy, Victor. Ed. Tea in Health and Disease Prevention, Academic Press Inc, 2012, 1st Edition, 425-435. 被引用次数：3
41. Liang Zhang, Wan-fang Shao, Li-feng Yuan, Peng-fei Tu, Zhi-zhong Ma. Decreasing pro-inflammatory cytokine and reversing the immunosenescence with extracts of Pu-erh tea in senescence accelerated mouse (SAM). Food Chemistry, 2012, 135 (4): 2222–2228. 3.391 IF. 7中科院1区. 被引用次数：21
42. Jin-Hua Qin, Ning Li, Peng-Fei Tu, Zhi-Zhong Ma, Liang Zhang*. Change in Tea Polyphenol and Purine Alkaloid Composition during Solid-State Fungal Fermentation of Postfermented Tea, Journal of Agricultural and Food Chemistry, 2012, 60 (5): 1213–1217. 2.912 IF.中科院1区. 被引用次数：27
43. Che Yan-Yun, Liang Zhang, Li Ning, Zeng Ke-Wu, Tu Peng-Fei. Triterpenoid saponins from Ilex mamillata C.Y. Wu ex C.J. Tseng. Natural Product Research, 2012. 26(21):1991-1995. 被引用次数：9
44. Xin-Fu Zhang, Ying-Ying Han, Guan-Hu Bao, Tie-Jun Ling, Liang Zhang, Li-Ping Gao, Tao Xia. A New Saponin from Tea Seed Pomace (Camellia oleifera Abel) and Its Protective Effect on PC12 Cells. Molecules. 2012, 17(10):11721-11728. 被引用次数：35
45. Ning Li, Jia-Yu Zhang, Ke-Wu Zeng, Liang Zhang, Yan-Yun Che, Anti-inflammatory homoisoflavonoids from the tuberous roots of Ophiopogon japonicas, Fitoterapia, 2012, 83(6):1042-1045. 被引用次数：48
46. 吴慧, 张梁, 朱圣洁, 张正竹. 绿茶水提物中主要次生代谢产物的分离纯化与结构鉴定. 天然产物研究与开发, 2012, 12: 1750-1752.
47. 张梁*. 如何培养研究生的科研兴趣. 科技导报, 2012, 30(03): 82.
48. Liang Zhang, Zhi-Zhong Ma, Yan-Yun Che, Ning Li, Peng-Fei Tu, Protective effect of a new amide compound from Pu-erh tea on human microvascular endothelial cell against cytotoxicity induced by hydrogen peroxide, Fitoterapia, 2011, 82(2), 267-271. 2 区2.345 IF被引用次数：23
49. Liang Zhang, Ning Li, Yan-Yun Che, Zhi-zhong Ma, Peng-Fei Tu. Development of the fingerprints of aged Pu-erh tea and ripened Pu-erh tea by high-performance liquid chromatography, Journal of Chinese Pharmaceutical Sciences, 2011, 20(4): 351-357. 被引用次数：16
50. Liang Zhang, Ning Li, Zhi-Zhong Ma, Peng-Fei Tu. Comparison of the chemical constituents of aged Pu-erh tea, ripened Pu-erh tea and other teas using HPLC-DAD-ESI-MSn. Journal of Agricultural and Food Chemistry, 2011, 59 (16): 8754–8760. 2.912 IF. 中科院1区. 被引用次数：70
51. CHE Yan-Yun, LI Ning, Liang Zhang, TU Peng-Fei, Triterpenoid Saponins from the Leaves of Ilex kudingcha, Chinese Journal of Natural Medicines, 2011, 9(1): 22-25. 被引用次数：13
52. Xiao-Juan Lai, Liang Zhang, Jun-Song Li, Hang-Qing Liu, Xun-Hong Liu, Liu-Qing Di, Bao-Chang Cai, Li-Hua Chen，Comparative pharmacokinetic and bioavailability studies of three salvianolic acids after the administration of Salviae miltiorrhizae alone or with synthetical borneol in rats, Fitoterapia, 2011, 82(6):883-888. 被引用次数：41
53. Chu Song-ling, Fu Hong, Yang Jin-xia, Liu Geng-xin, Dou Pan, Liang Zhang, Tu Peng-fei, Wang Xue-mei, A randomized double-blind placebo-controlled study of Pu’er tea extract on the regulation of metabolic syndrome. Chinese Journal of Integrative Medicine. 2011, 17(7): 492-498. 被引用次数：25
54. 张梁, 徐德生, 冯怡, 2007, 芍药甘草复方大鼠血中移行组分归属分析研究，中国中药杂志, 32(17): 1789-1791.
55. 沈岚, 张梁, 冯怡, 徐德生, 林晓, 2009,芍药甘草复方配伍药动学研究，中成药, 31(3): 374-377.
56. 沈岚, 张梁, 冯怡, 徐德生, 林晓, 2008,芍药甘草复方效应组分谱效关系研究， 中国中药杂志, 33(22): 2658-2662.
57. 陈丽华, 冯怡, 徐德生, 李俊松, 张梁, 2007, 芍药甘草复方效应组分对大鼠胃底环行肌条作用的研究，中药药理与临床, 23(6): 1-4.
58. 沈岚; 冯怡; 徐德生; 林晓; 张梁, 2008, 配伍前后芍药特征化学组分体内药动学变化研究，中国药学杂志, 43(23): 1774-1776.
59. 毕丹, 宋月林, 张梁, 陈东, 屠鹏飞, 2009,鹅胆的化学成分研究 ，中草药, 40(10): 1543-1545.
60. 陈丽华, 冯怡, 徐德生, 李俊松, 张梁, 汪益涵, 2008, 含甘草酸效应组分微丸的制备及其性质考察，中国中药杂志, 33(5): 509-513.
61. 沈岚; 冯怡; 徐德生; 林晓; 洪燕龙; 王优杰; 张梁，2010, 基于HPLC-DAD-ESI-MS技术的芍药甘草汤体内外物质基础变化研究, 中国中药杂志, 35(15): 1947-1952.
