姓名：孙嘉

性别：女

学历：博士研究生

职称：教授

工作单位：江南大学

教育情况：

2001-2005    新加坡国立大学生命科学系 学士

2005-2009    新加坡国立大学医学院         博士

工作经历：

2005-2009    新加坡国立大学医学院                助理研究员

2009-2013    瑞典卡罗林斯卡医学院                博士后

2013-2014    江南大学                                 副教授，硕士生导师

2014-至今    江南大学                                 教授，博士生导师

所受奖项：

1. 2018 江苏省双创团队领军人才

2. 2015 益海嘉里优秀青年教师奖

3. 2015 江苏省科协优秀学术论文奖

4. 2014 江苏省双创计划人才

5. 2013 中组部青年千人、无锡市社会事业领军人才

6. 2012 瑞典Rolf Luft Fellowship，Rolf Luft糖尿病研究基金会研究奖（当年唯一）

主要研究方向：

长期从事食品营养、微生物与胰-肠区域免疫稳态调控研究，主要开展：1）胰腺-肠道区域黏膜免疫稳态调控与机理研究；2）胰腺免疫稳态调控的新机制及营养干预研究；3）酪酸梭菌及特异性膳食纤维对机体免疫稳态的调控及其应用开发。近5年在Immunity (IF 24.2), Allergy, Front Immunol, FASEB J, Mol Nutr Food Res等食品科技、免疫学领域国际权威期刊发表一作/通讯SCI论文20余篇，总影响因子超过150，总引用787次；研究工作开创了肠稳态调控胰岛免疫稳态的新领域方向，被加拿大皇家科学院院士Robert Hancock教授等权威科学家及同行在Nature, Nat Rev Immnol, Nat Rev Microbiol, Immunity, Annu Rev Nutr, Annu Rev Immunol等免疫学、营养学领域顶级期刊做热点/正面评论，Faculty 1000 选列为推荐文章；国家自然基金委、国内外主流科学媒体（Science Daily，生物通等）对申请人的研究工作进行了亮点报道。多次受邀出席国内国际学术会议并做学术报告。基于上述创新性研究成果，还获得国家千人计划（青年）、江苏省双创团队领军人才、江苏省双创人才在内的省部级人才、科研项目10余项。

代表性著作：

Sun J, Furio L, Mecheri R, van der Does A M., Lundeberg E, Saveanu L, Chen YQ, van Endert P, Agerberth B, Diana J*. Pancreatic β-cells express a host defense peptide regulating autoimmune diabetes under the influence of the gut microbiota.   Immunity. 2015;43:304-317.（IF=24.082）

Ren Z, Li H, Zhang M, Zhao Y, Fang X, Li X, Chen W, Zhang H, Wang Y, Pan LL*, Sun J*. A Novel Derivative of the Natural Product Danshensu Suppresses Inflammatory Responses to Alleviate Caerulein-Induced Acute Pancreatitis. Front Immunol. 2018;9:2513.（IF=5.511）

Pan LL, Deng Y-Y, Wang R, Wu C, Li J, Niu W, Yang Q, Madhav B, Gudmundsson HG, Agerberth B, Diana J and Sun J*. Lactose Induces Phenotypic and Functional Changes of Neutrophils and Macrophages to Alleviate Acute Pancreatitis in Mice. Front Immunol. 2018; 9:751.（IF=5.511）

Jia L, Shan K, Pan LL, Feng N, Lv Z, Sun Y, Li J, Wu C, Zhang H, Chen W, Diana J, Sun J*, Chen YQ*. Clostridium butyricum CGMCC0313.1 Protects against Autoimmune Diabetes by Modulating Intestinal Immune Homeostasis and Inducing Pancreatic Regulatory T Cells. Front Immunol. 2017;8:1345.（IF=5.511）

He Y, Wu C, Li J, Sun Z, Zhang H, de Vos P, Pan LL* and Sun J*. Inulin-Type Fructans Modulates Pancreatic–Gut Innate Immune Responses and Gut Barrier Integrity during Experimental Acute Pancreatitis in a Chain Length-Dependent Manner. Front Immunol. 2017;8:1209.（IF=5.511）

Pan LL, Li J, Shamoon M, Bhatia M, Sun J*. Recent Advances on Nutrition in Treatment of Acute Pancreatitis. Front Immunol. 2017;8:762.（IF=5.511）

Jia L, Li D,Feng N, Shamoon M, Sun Z, Ding L, Zhang H, Chen W, Sun J*, Chen YQ*. Anti-diabetic Effects of Clostridiumbutyricum CGMCC0313.1 through Promoting the Growth of Gut Butyrate-producing Bacteria in Type 2 Diabetic Mice. Sci Rep. 2017;7(1):7046.（IF=4.122）

Chen K, Chen H, Faas MM, de Haan BJ, Li J, Xiao P, Zhang H, Diana J, de Vos P, Sun J*. Specific inulin-typefructan fibers protect against autoimmune diabetes by modulating gut immunity, barrier function, and microbiota homeostasis. Mol Nutr Food Res. 2017;61(8). （IF=5.151）

Sun Y, He Y, Wang F, Zhang H, de Vos P, Sun J*. Low-MethoxylLemon Pectin Attenuates Inflammatory Responses and Improves Intestinal BarrierIntegrity in Caerulein-Induced Experimental Acute Pancreatitis. Mol Nutr Food Res. 2017;61(4). （IF=5.151）

Dong Z, Shang H, Chen YQ, Pan LL, Bhatia M, Sun J*. Sulforaphane protects pancreatic acinar cell injury by modulating Nrf2-mediated oxidative stress and NLRP3 inflammatory pathway. Oxid Med Cell Longev. 2016; (7):1-12.（IF=4.593）

Shang H, Sun J*, Chen YQ*. Clostridium butyricum CGMCC0313.1 modulates lipid profile, insulin resistance and colon homeostasis in obese mice. PLos one, 2016;11(4):e0154373.（IF=2.806）

Deng YY, Wang B, Shamoon M, He Y, Bhatia M, and Sun J*. Cathelicidin antimicrobial peptide modulates acute pancreatitis in mice. Mol Med Rep. 2016;13(5):3881-5.（IF=1.692）

Yang Q, Sun J, Chen YQ*. Multi-dimensional, comprehensive sample extraction combined with LC-GC/MS analysis for complex biological samples: application in the metabolomics study of acute pancreatitis. RSC advances. 2016;6(31):25837-25849.（IF=3.108）

Sun J*, Xu M, Diana J, Ortsäter H, ‎Flodström-Tullberg M, Haeggström Z. J, Agerberth B. The antimicrobial peptide cathelicidin is a positive regulator of pancreatic β-cell function. FASEB J. 2016;30:884-894.（IF=5.595）

Shamoon M, Deng Y, Chen Y Q, Bhatia M, Sun J*. Therapeutic implications of innate immune system in acute pancreatitis. Expert Opin Ther Targets. 2016;20(1):73-87.（IF=4.873）

Sun J* and Bhatia M*. Substance P at the Neuro-Immune Crosstalk in the Modulation of Inflammation, Asthma and Antimicrobial Host Defense. Inflamm Allergy Drug Targets. 2014;13(2):112-20.

Sun J, Dahlén B, Agerberth B, Haeggström Z. J. The host defense peptide LL-37 induces release of eicosanoids and eosinophil cationic protein from human eosinophils – implications for asthma. Allergy. 2013;68:304-311.（IF=6.335）

Sun J, Ramnath RD, Tamizhselvi R, Bhatia M. PKC and PI3K-Akt Pathways are Involved in Substance P-Induced ERK1/2-NF-κB Activation and Chemokine Expression in Mouse Macrophages. FASEB J. 2009;23:997-1010.（IF=5.595）