姓名:胡宇

性别:

学历:博士研究生,博士

职称:教授

工作单位:杭州师范大学医学院

 

教育情况:

19799-19847月就读新疆医学院卫生系,本科,获学士学位;

19849-19877月攻读环境卫生学硕士研究生,获华西医科大学医学硕士;

19999-20027月于新疆医科大学攻读劳动卫生与环境卫生学博士研究生,获博士学位。

20027-200510月在纽约大学做博士后。

 

 

工作经历:

19879-20027月在新疆医科大学公共卫生学院从事劳动卫生与环境卫生学教学与科研工作,历任助教(1987),讲师(1990),副教授(1994),教授(2000);

20027-20113月在纽约大学做博士后、研究员。

20113月加盟杭州师范大学医学院,任教授。

 

 

 

所受奖项:

11993年主持研究项目“饮用高砷井水对人体末梢微循环的影响”获新疆维吾尔自治区科技进步三等奖,排名第一。1996年获八五重大科技成果奖。

41994年作为主要研究成员参加的研究项目“氟砷联合中毒研究” 获新疆维吾尔自治区科技进步二等奖,排名第八。

5. 1994年作为主要研究成员参加的研究项目“新疆农村住宅卫生学调查”获国家卫生部科技进步三等奖,排名第三。

6. 1996年作为主要研究成员参加的研究项目“新疆氟砷联合中毒研究” 获国家科技进步三等奖,排名第八。

 

 

 

主要研究方向:

环境与健康;健康管理

 

 

代表性著作:

1Mao-Wen Weng, Hyun-Wook Lee, Bongkun Choi, Hsiang-Tsui Wang, Yu Hu, Manju Mehta, Dhimant Desai, Shantu Amin, Yi Zheng, Moon-Shong Tang AFB1 hepatocarcinogenesis is via lipid peroxidation that inhibits DNA repair, sensitizes mutation susceptibility and induces aldehyde-DNA adducts at p53 mutational hotspot codon 249. Oncotarget, 2017, Vol. 8, (No. 11), pp: 18213-18226

2Wang, SH, Lee, Hyun-wook, Weng, Mao-wen, Hu Y, Liu, Yan, Donin, Nicholas, Huang, William C, Frederick.beland, Tang, Moon-Shong Acrolein- and 4-Aminobiphenyl-DNA Adducts in Human Bladder Mucosa and Tumor Tissue and Their Mutagenicity in Human Urothelial Cells. Oncotarget. 2014 Jun 15; 5(11):3526-40

315Wang HT, Hu Y, Tong D, Huang J, Gu L, Wu XR, Chung FL, Li GM, Tang MS 2012 Effect of carcinogenic acrolein on DNA repair and mutagenic susceptibility. J Biol Chem. Jan 287(15):12379-86

4 MS, Wang HT, Hu Y , Chen WS, Feng Zhaohui , Hu WW 2011 Acrolein induced DNA  damage, mutagenicity and effect on DNA repair. Molecular Nutrition & Food Research  55(9):1291-300.

5Wang HT, Zhang SHu Y, Stephen Hecht, Tang MS. 2009. Mutagenicity of Acrolein-DNA adducts. Chemical Research in Toxicology, 22(3):511-517

6Hu Y, Li G, Xue X, Zhou Z, Li X, Fu J, Cohen B, Roy N, Li D, Sun J,Nan P, Tang M, Huang X, Roy N, Qu Q 2008. PAH-DNA adducts in a Chinese population: in relation to PAHs exposure, smoking, and polymorphisms of metabolic and DNA repair genes. Biomarkers 131):27-40

7 Oyang W*, Hu Y*,Li J*, Yan Y, Zhang D, Qu Q, Song L, Huang C. 2007 Direct Evidence for the Critical Role of NFAT3 in Benzo[a]pyrene Diol-Epoxide-Induced Cell Transformation through Mediation of Inflammatory Cytokine TNFa in Mouse Epidermal Cl41 Cells. Carcinogenesis 28 (10): 2218-2226 *: Oyang W, Hu Y and Li J have contributed equally to this work

8 Hu Y, Xue X, Zhou Z, Fu J, Cohen B, Melikian AA, Li D, Tang M, Huang X, Roy N, Qu Q. 2006. Sensitive biomarkers of polycyclic aromatic hydrocarbons (PAHs): urinary 1-Hydroxypyrene glucuronide in relation to smoking and low ambient lebvels of exposure. Biomarkers 11(4): 306-318

9 Yan Y, Li J, Ouyang W, Ma Q, Hu Y, Zhang D, Ding J, Qu Q, Subbaramaiah K, Huang C. 2006.Nuclear Factor of Activated T Cells 3 (NFAT3) Is Specifically Required for Tumor Necrosis Factor-a (TNF-a)-induced Cyclooxygenase-2 (COX-2) Expression and Cell Transformation in Cl41 Cells. JCS 119(14):2985-2994

10Feng Z, Hu W, Hu Y and Tang MS. 2006. Acrolein is a major cigarette-related lung cancer agent: Preferential binding at p53 mutational hotspots and inhibition of DNA repair. PNAS 103(42):15404-15409

11Qu, Q, Hu, Y; Xue, X; Zhou, Z; Li, X; Fu, J; Cohen, B; Tang, E; Roy, N; Melikian, AA; Li, D."Validation of biomarkers in humans exposed to PAHs". Toxicology & applied pharmacology.2004; 97:187