Name: LIU Jian

Gender: Male

Degree: Ph.D

Title: Professor

Organization: Hefei University of Technology

Education Experience:

Ph.D. (2001/09-2006/07)

Department of Molecular and cellular biology, School of Life Science, University of Science and Technology of China (USTC), Hefei, Anhui, China.                    

B.S. (1991/09-1995/07)

Department of Biology, Anhui University, Hefei, Anhui, China.

Work Experience:

2009/11-present  Professor for Molecular and Cellular Biology                                  

Hefei University of Technology, Hefei, Anhui, China

2009/05-2009/11  Postdoctoral Associate                                                                         

Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA

2007/07-2009/04  Postdoctoral Associate                                                                         

Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA,

1995/07-2001/08  Pharmacist                                                                               

Division of Pharmacy, Anhui Provincial Hospital, Hefei, Anhui, China

Rewards:

The Awards for Huangshan Scholar (Award No. 407-040020), 04/2011-04/2015

Research Area:

Food nutrition and safety mechanism about obesity and related metabolic diseases.

Publication:

1)        Liu J, Divoux A,  Sun J, Zhang J, Clément K, Glickman JN, Sukhova GK, Wolters PJ, Du J, Doria A, Libby P, Blumberg RS, Kahn BB, Shi GP. Genetic Deficiency and pharmacological stabilization of mast cells reduces diet-induced obesity and diabetes in mice. Nat Med. 2009; 15(8):940-947. (SCI, IF=22.864; Cited Numbers: 176 )

2)        Liu J, Sukhova GK, Sun JS, Xu WH, Libby P, Shi GP. Lysosomal cysteine proteases in atherosclerosis. Arterioscler Thromb Vasc Biol. 2004; 24(8):1359-1366. (SCI, IF=6.338; Cited Numbers: 186)

3)        Liu J, Sukhova GK, Yang JT, Sun J, Ma L, Ren A, Xu WH, Fu H, Dolganov GM, Hu C, Libby P, Shi GP. Cathepsin L expression and regulation in human abdominal aortic aneurysm, atherosclerosis, and vascular cells. Atherosclerosis. 2006;184(2):302-311. (SCI, IF=3.706; Cited Numbers: 88)

4)        Liu J, Ma L, Yang J, Ren A, Sun Z, Yan G, Sun J, Fu H, Xu W, Hu C, Shi GP. Increased serum cathepsin S in patients with atherosclerosis and diabetes. Atherosclerosis. 2006;186(2):411-419. (SCI, IF=3.706; Cited Numbers: 40) 

5)        Liu J, Shi GP, Zhang WQ, Zhang GR, Xu WH. Cathepsin L function in insect moulting: molecular cloning and functional analysis in cotton bollworm, Helicoverpa armigera. Insect Mol Biol. 2006; 15(6):823-834. (SCI, IF=3.044; Cited Numbers: 27)

6)        Zimonjic DB, Liu J, Xu WH, Zhou X, Popescu NC, Shi GP. Assignment of murine placental cathepsin R to mouse chromosome bands 13B2-B3 by fluorescence in situ hybridization. Cytogenet Genome Res. 2005; 111(1):96. (SCI, IF=1.839)

7)        Sun J, Sukhova GK, Yang M, Wolters PJ, MacFarlane LA, Libby P, Sun C, Zhang Y, Liu J, Ennis TL, Knispel R, Xiong W, Thompson RW, Baxter BT, Shi GP. Mast cells modulate the pathogenesis of elastase-induced abdominal aortic aneurysms in mice. J Clin Invest. 2007; 117(11):3359-3368. (SCI, IF=12.812)

8)        Yang M, Zhang Y, Pan J, Sun J, Liu J, Libby P, Sukhova GK, Doria A, Katunuma N, Peroni OD, Guerre-Millo M, Kahn BB, Clement K, Shi GP. Cathepsin L activity controls adipogenesis and glucose tolerance. Nat Cell Biol. 2007; 9(8):970-977.(SCI, IF=20.761)

9)        Tang B, Chen X, Liu Y, Tian H, Liu J, Hu J, Xu W, Zhang W. Characterization and expression patterns of a membrane-bound trehalase from Spodoptera exigua. BMC Mol Biol. 2008; 20(9):51. (SCI, IF=2.796)

10)    Yang M, Sun J, Zhang T, Liu J, Zhang J, Shi MA, Darakhshan F, Guerre-Millo M, Clement K, Gelb BD, Dolgnov G, Shi GP. Deficiency and inhibition of cathepsin K reduce body weight gain and increase glucose metabolism in mice. Arterioscler Thromb Vasc Biol. 2008;28(12):2202- 2208. (SCI, IF=6.338)

11)    Wei ZJ, Liao AM, Zhang HX, Liu J, Jiang ST. Optimization of supercritical carbon dioxide extraction of silkworm pupal oil applying the response surface methodology. Bioresour Technol. 2009;100(18):4214-4219. (SCI, IF= 4.750)

12)    Sun J, Zhang J, Lindholdt JS, Sukhova GK, Liu J, Pejler G, Gurish MF, Stevens RL, Libby P,Thompson RW, Shi GP. Critical role of mast cell chymase in mouse abdominal aortic aneurysm formation. Circulation. 2009;120:973-982 (SCI, IF=15.202)

13)    Yu W, Liu J, Shi MA, Wang J, Xiang M, Kitamoto S, Wang B, Sukhova GK, Murphy GF, Orasanu G, Grubb A, Shi GP.Cystatin C Deficiency Promotes Epidermal Dysplasia in K14-HPV16 Transgenic Mice. PLoS One. 2010; 5(11):e13973(SCI, IF=3.730)

Zhang Y, Lu YX, Liu J, Yang C, Feng QL, Xu WH. A Regulatory Pathway, Ecdysone-Transcription Factor Relish-Cathepsin L, Is Involved in Insect Fat Body Dissociation. PLoS Genet.2013; 9(2):e1003273. (SCI, IF=8.517)