
姓名:高福
性别:男
学历:博士
职称:研究员、中国科学院院士
工作单位:中国疾病预防控制中心
教育情况:
1991-1994 英国牛津大学 博士 ( DPhil-Oxon )
1983-1986 北京农业大学 硕士
1979-1983 山西农业大学 学士
工作经历:
先后在加拿大卡尔加里大学、英国牛津大学,美国哈佛大学/哈佛医学院从事博士后研究工作。
2001-2004年任英国牛津大学讲师、博士生导师、研究组长。
2004-2008年任中国科学院微生物研究所所长。
2008年至今任中国科学院病原微生物与免疫重点实验室主任。
2010年至今任牛津大学客座教授。
2011年5月至今任中国疾病预防控制中心副主任。
所受奖项:
中国科学技术协会首届“青年科技奖”获得者( 1988 年)
北京市科学技术协会“青年优秀论文奖”获得者( 1988 年)
中国微生物学会“青年优秀论文奖” 获得者( 1989 年)
英国文化委员会与中国国家教育委员会“中英友好奖学金” 获得者( 1991 年)
英国 Wellcome Trust “International Travelling Fellow” (1998 年 )
国家自然科学基金委员会“海外青年学者合作研究基金”(杰出青年B类)获得者(2002年)
教育部“春晖计划”学术休假基金获得者( 2003 年)
中国科学院“百人计划”获得者( 2004 年)
973首席科学家( 2005年 )
国家自然科学基金委员会“杰出青年科学基金”(A类)( 2005年 )
主要研究方向:
病原微生物跨种间传播机制与分子免疫学,主要从事T细胞识别、流感病毒等囊膜病毒侵入的分子机制、禽流感等动物源性病原跨种间传播的机制研究等。
代表性著作:
Fuliang Chu, Zhiyong Lou, Yu Wai Chen, Yiwei Liu, LiLi Zong, Bin Gao Abdul Hamid Khan, John I. Bell, Zihe Rao and George F. Gao*,2007, First glimpse of the peptide presentation by rhesus macaque MHC class I: crystal structures of Mamu-A*01 complexed with two immunogenic SIV epitopes and insights into CTL escape, The Journal of Immunology, 178(2):944-952
Suhua Chang, Jiajie Zhang, Xiaoyun Liao, Xinxing Zhu, Dahai Wang, Jiang Zhu, Tao Feng, Baoli Zhu, George F. Gao, Jian Wang, Huanming Yang, Jun Yu * and Jing Wang *, 2006, Influenza Virus Database (IVDB): an integrated information resource and analysis platform for influenza virus research, Nucleic Acids Research, 35(Database issue):D376-80
Zhiyong Lou, Yanhui Xu, Kehui Xiang, Nan Su, Lan Qin, Xu Li, George F. Gao, Mark Bartlam and Zihe Rao, 2006, Crystal structures of Nipah and Hendra virus fusion core proteins, FEBS Journal, 273 : 4538–4547
Yueyong Liu, Yanhui Xu, Zhiyong Lou, Jieqing Zhu, Xuebo Hu, George F. Gao , Bingsheng Qiu *, Zihe Rao *, Po Tien *, 2006, Structural characterization of Mumps virus fusion protein core, Biochemical and Biophysical Research Communications 348: 916–922
Yuxia Zhang, Yanlu Zan, Ming Shan, Changmei Liu, Ming Shi, Wei Li, Zhixin Zhang, Na Liu, Fusheng Wang, Weidong Zhong, Fulian Liao, George F. Gao *, Po Tien *, 2006, Effects of heat shock protein gp96 on human dendritic cell maturation and CTL expansion, Biochemical and Biophysical Research Communications 344: 581–587
Zheng Fan , Yue Zhuo, Xinyu Tan, Zhi Zhou, Jiangang Yuan, Boqin Qiang, Jinghua Yan, Xiaozhong Peng, George F. Gao*, 2006, SARS-CoV nucleocapsid protein binds to hUbc9, a ubiquitin conjugating enzyme of the sumoylation system, Journal Medical Virology (in press)
David K Cole*, Pierre J Rizhallah, Jonathan M Boulter, Malkit Sami, Anne-lise Vuidepot, Meir Glick, Feng Gao, John I Bell, Bent K Jakobsen*, George F Gao*, 2006, Computational design and crystal structure of an enhanced affinity mutant human CD8aa co-receptor, PROTEINS: Structure, Function, and Bioinformatics (in press).
Shibichakravarthy Kannan, Aaron Audet, Jessica Knittel, Saman Mullegama, George F.Gao and Min Wu, 2006, Src kinase Lyn is crucial for Pseudomonas aeruginosa internalization into lung cells. European journal of Immunology, 36:1739-1752
Minghai Zhou, Dongping Xu, Xiaojuan Li, Hongtao Li, Ming Shan, Jiaren Tang, Min Wang, Fu-Sheng Wang, Xiaodong Zhu, Hua Tao, Wei He, Po Tien*, and George F Gao*,2006, Screening and Identification of Severe Acute Respiratory Syndrome-Associated Coronavirus-Specific CTL Epitopes, Journal of Immunology, 177: 2138-2145
Jiaqi Tang*#, Changjun Wang#, Youjun Feng#, Weizhong Yang#, Huaidong Song#, Zhihai Chen#, Hongjie Yu#, Xiuzhen Pan, Xiaojun Zhou, Huaru Wang, Bo Wu, Haili Wang, Huamei Zhao, Ying Lin, Jianhua Yue, Zhenqiang Wu, Xiaowei He, Feng Gao, Abdul Hamid Khan, Jian Wang, Guo-Ping Zhao, Yu Wang*, Xiaoning Wang*, Zhu Chen, George F Gao*, 2006,Streptococcal toxic shock syndrome caused by Streptococcus suis serotype2. PLoS Medicine,3(5):668-676 (#shared the first author)
David K. Cole, Pierre J. Rizkallah, Feng Gao, Neil I. Watson, Jonathan M. Boulter, John I. Bell, Malkit Sami, George F. Gao* & Bent K. Jakobsen*.2006.Crystal structure of HLA-A*2402 complexed with a telomerase peptide. European Journal of Immunology. 36:170-179
Li X, Liu X, Sun F, Gao J, Zhou H, Gao GF, Bartlam M, Rao Z. Crystal structure of the N-terminal SH3 domain of mouse betaPIX, p21-activated kinase-interacting exchange factor. Biochemical and Biophysical Research Communications. 2006 Jan 6; 339(1):407-14
Jinhua Liu#, Haixia Xiao#, Fumin Lei#, Qingyu Zhu, Kun Qin, Xiaowei Zhang, Xinglin Zhang, Deming Zhao, Guihua Wang, Youjun Feng, Juncai Ma, Wenjun Liu, Jian Wang, George F. Gao*. 2005. Highly pathogenic H5N1 influenza virus infection in migratory birds. Science. 309:1206(#shared the first author)
Ling Ni, Linqing Zhao, Yuan Qian, Jieqing Zhu, Zhibo Jin, Yu Wai Chen, Po Tien*, George F Gao*, 2005, Design and characterization of human respiratory syncytial virus entry inhibitors. Antiviral Therapy. 10:833-840
Jieqing Zhu, Xiuli Jiang, Yueyong Liu, Po Tien, George F Gao.2005. Design and characterization of viral polypeptide inhibitors targeting Newcastle disease virus fusion. Journal of Molecular Biology. 354:601-613
Ling Ni, Linqing Zhao , George F. Gao , Yuan Qian ,*, Po Tien ,* 2005.The antibodies directed against N-terminal heptad-repeat peptide of hRSV fusion protein and its analog-5-Helix inhibit virus infection in vitro. Biochemical and Biophysical Research Communications 331:1358-1364
Ling Ni, George F. Gao,*, Po Tien ,* Rational design of highly potent HIV-1 fusion inhibitory proteins: Implication for developing antiviral therapeutics. Biochemical and Biophysical Research Communications 332:831-836
Zheng Zhang, Dongping Xu, Yonggang Li, Lei Jin, Ming Shi, Min Wang, Xianzhi Zhou, Hao Wu, George F. Gao, Fu-Sheng Wanga,* 2005. Longitudinal alteration of circulating dendritic cell subsets and its correlation with steroid treatment in patients with severe acute respiratory syndrome. Clinical Immunology 116(3):225-35.
Fuliang Chu ,Zhiyong Lou, Bin Gao, John I. Bell, Zihe Rao and George F. Gao*,2005,Complex assembly, crystallization and preliminary X-ray crystallographic studies of rhesus macaque MHC Mamu-A*01 complexed with an immunodominant SIV-Gag nonapeptide. Acta Crystallographica Section F Structural Biology and Crystallization Communications F61: 614–616.
Li,H., Zhou,M., Han,J., Zhu,X., Dong,T., George F. Gao*, and Po Tien* , 2005, Generation of murine CTL by a hepatitis B virus-specific peptide and evaluation of the adjuvant effect of heat shock protein glycoprotein 96 and its terminal fragments. The Journal of Immunology Jan 1;174(1):195-204
George F. Gao. 2005, Filling the hole: evidence of a small molecule binding to the fusion core pocket in human respiratory syncytial virus. Expert Opinion on Investigational Drugs 14(2): 195-197
Yuan, F., Lou, Z., Li, X., Chen, Y., John I. Bell, Zihe Rao, George F. Gao*. 2005,Refolding,crystallization and preliminary X-ray structural studies of the West Nile virus envelope(E) protein domain Ⅲ. Acta Crystallographica Section F Structural Biology and Crystallization Communications F61,421-423
Li, S., Zhu, J., Peng, Y., Cui, S., Wang, C., George F. Gao*., Tien, P*. 2005, Characterization of BIV Env core: Implication for mechanism of BIV-mediated cell fusion. Biochemical and Biophysical Research Communications (BBRC) 329(2005) 603-609
David K. Cole, Pierre J. Rizkallah, Malkit Sami, Nikolai M. Lissin, Gao.F., John I. Bell, Jonathan M. BBoulter, Meir Glick, Anne-Lise Vuidepot, Bent K. Jakobsen and George F. Gao*. Crystallization and preliminary X-ray structural studies of a high-affinity CD8ααco-receptor to pMHC. Acta Crystallographica Section F Structural Biology and Crystallization Communications F61
Ni, L., Zhu, J., Zhang, J., Yan, M., George F. Gao*, Po Tien*. 2005, Design of recombinant protein-based SARS-CoV entry inhibitors targeting the heptad-repeat regions of the spike protein S2 domain. Biochemical and Biophysical Research Communications (BBRC) 330:39-45.
Wang, X., Bai, Y., Zhang, G., Zhao, J., Wang, M., George F. Gao*. 2005, Structure and function study of paramyxovirus fusion protein heptad repeat peptides. Archives of Biochemistry and Biophysics(ABB) 436(2005) 316-322
Xu,D.,Zhang,Z.,Jin,L.,Chu,F.,Mao,Y.,Wang,H.,Liu,M.,Wang,M.,Zhang,L., G.F. Gao and Wang,F.S.2005,Persistent shedding of viable SARS-CoV in urine and stool of SARS patients during the convalescent phase. European Journal of Clinical Microbiology & Infectious Diseases 24:165-171