姓名：刘虎威
性别：男
学历：博士
职称：教授
工作单位：北京大学化学与分子工程学院
教育情况：
1978.10-1982.7 北京工业学院（现北京理工大学）高分子材料专业，学士学位
1984.9-1990.7 北京理工大学应用化学专业，硕士、博士学位
工作经历：
1990.8 –今 北京大学化学与分子工程学院，讲师，副教授，教授
1995.9-1996.7 芬兰赫尔辛基大学化学系，交流学者
1996.7－1997.3 美国普渡大学化学系，BAS公司，交流学者
1999.9-2001.2 法国南锡一大 合作研究
所受奖项：
中国分析测试学会奖，一等奖、二等奖、三等奖各一次
主要研究方向：
生物药物分离与检测，主要包括色谱（毛细管电泳）-质谱分析，药物分析，生物与临床分析
代表性著作：
近5年发表的部分代表性学术论文：
2017
1. Li Yang, Pu Lv, Wanpeng Ai, Linnan Li, Sensen Shen, Honggang Nie, Yabing Shan, Yu Bai, Yining Huang*, Huwei Liu*, Lipidomic analysis of plasma in patients with lacunar infarction using normal-phase/reversed-phase two-dimensional liquid chromatography–quadrupole time-of-flight mass spectrometry, Anal. Bioanal. Chem., 2017, 409, 3211–3222
2. Xianjiang Li, Xin Wang, Wen Ma, Wanpeng Ai, Yu Bai, Li Ding* and Huwei Liu*, Fast analysis of glycosides based on HKUST-1-coated monolith solid-phase microextraction and direct analysis in real-time mass spectrometry, J. Sep. Sci., 2017, 40, 1589-1596
3. Wen Ma, Linnan Xu, Xianjiang Li, Sensen Shen, Mei Wu, Yu Bai* and Huwei Liu, Cysteine-Functionalized Metal-Organic Framework: Facile Synthesis and High Efficient Enrichment of N-Linked Glycopeptides in Cell Lysate, ACS Appl. Mater. Interfaces, 2017, 9, 19562-19568
4. Ze Li, Jialing Zhang, Yiwei Zhang, Yu Bai and Huwei Liu*, New strategy for further improving the detection sensitivity of direct analysis in real time mass spectrometry, J. Anal. Test. 2017, 1, 3
5. 刘虎威∗，白玉, 脂质组学及其分析方法, 色谱，2017，35，86-90
6. Li Yang, Yu Bai, Xiaohong Han, Yuankai Shi, Huwei Liu*, Lipidomic analysis of plasma in patients with hepatocellular carcinoma using normal-phase / reversed-phase two-dimensional liquid chromatography- quadrupole time-of-flight mass spectrometry，J. Anal. Test. accepted
7. Min Li, Li Yang, Yining Huang, Yu Bai, Huwei Liu*, Sphingolipids profiling of plasma in patients with diabetes mellitus associated with atherosclerosis by a novel normal-phase UPLC-QToF MS method, J. Anal. Test., accepted
8. Shiyao Song, Huwei Liu, Yu Bai*, Supercritical fluid chromatography and its application in lipid isomers separation, J. Anal. Test., accepted
9. 张一丁，徐姝婷，白玉，刘虎威*, 表面等离子体共振-质谱联用技术研究进展, 分析科学学报，accepted
10. Sensen Shen, Li Yang, Linnan Li, Cun Cai, Yu Bai, Huwei Liu, Plasma lipidomics reveals perturbed lipid metabolism and identifies potential lipid biomarkers of human colorectal cancer, submitted
11. Xianjiang Li, Wen Ma, Hongmei Li, Wanpeng Ai, Yu Bai, Huwei Liu, Sampling and Analyte Enrichment Strategies for Ambient Mass Spectrometry, ABC, submitted
12. Xiaoyue Qi, Ziyong Chang, Sensen Shen, Yu Bai, Andrew E. H. Wheatley, and Huwei Liu, A Smart Metal-Organic Framework Platform for Tumor Cell Capture, to be submitted
13. Linnan Li, Sensen Shen, Ruoyun Lin, Yu Bai and Huwei Liu, Rapid and Specific Luminescent Sensing of Cu(II) Ion with Porphyrinic Metal-Organic Framework, submitted
14. Sensen Shen, Yu Bai and Huwei Liu，Lipid biomarkers for liver cancer，in Markus R Wenk (Ed), Encyclopedia of Lipidomics, Springer, online, 2017, in press
15. Li Yang, Yu Bai and Huwei Liu，Lipid biomarkers for breast cancer，in Markus R Wenk (Ed), Encyclopedia of Lipidomics, Springer, online, 2017 in press
2016
1. Li Yang, Min Li, Yabing Shan, Sensen Shen, Yu Bai, Huwei Liu*, Recent advances in lipidomics for disease research, J. Sep. Sci., 2016, 39, 38–50
2. Yiding Zhang, Shuting Xu, Luhong Wen, Yu Bai *, Li Niu, Daqian Song, Huwei Liu *, Dielectric barrier discharge ionization based interface for online coupling surface plasmon resonance with mass spectrometry, Analyst, 2016, 141, 3343–3348
3. Xianjiang Li, Ze Li, Xin Wang, Honggang Nie, Yiding Zhang, Yu Bai, *, Huwei Liu *, Monolith dip-it: a bifunctional device for improving the sensitivity of direct analysis in real time mass spectrometry, Analyst，2016,141, 4947-4952
4. Linnan Li, Yiding Zhang, Xianjiang Li1, Sensen Shen, Hexiang Huang, Yu Bai, Huwei Liu*, Study on the interaction of uranyl with sulfated beta-cyclodextrin by affinity capillary electrophoresis and molecular dynamics simulation, Electrophoresis, 2016, 37, 2567–2573
5. Jialing Zhang, Ze Li, Zhigui Zhou, Yu Bai* and Huwei Liu*, Rapid screening and quantification of glucocorticoids in essential oils using direct analysis in real time mass spectrometry, Rapid Commun. Mass Spectrom. 2016, 30 (Suppl. 1), 133–140
6. Xiaoyue Qi, Long Chen, Chaoqun Zhang, XinyuanXu, Yiding Zhang, Yu Bai*and Huwei Liu*, NiCoMnO4: A Bifunctional Affinity Probe for Histagged Protein Purification and Phosphorylation Sites Recognition, ACS Appl. Mater. Interfaces, 2016, 8, 18675-18683
7. Xiaoyue Qi, Cuilan Chang, Xinyuan Xu, Yiding Zhang, Yu Bai and Huwei Liu*, Magnetization of 3D Homochiral MOFs for Efficient and Highly Selective Capture of Phosphopeptides, J. Chromatogr. A, 2016, 1468, 49–54
8. Shuting Xu, Yiding Zhang, linnan Xu, Yu Bai* and Huwei Liu*, Online Coupling Techniques in Ambient Mass Spectrometry, Analyst, 2016, 141, 5913-5921
9. Yiding Zhang, Wanpeng Ai, Yu Bai*, Yinglin Zhou, Luhong Wen, Xinxiang Zhang, Huwei Liu* An interface for online coupling capillary electrophoresis to dielectric barrier discharge ionization mass spectrometry, Anal. Bioanal. Chem., 2016, 408, 8655-8661
10. Linnan Li, Wen Ma, Sensen Shen, Hexiang Huang, Yu Bai and Huwei Liu*, A combined experimental and theoretical study on the extraction of uranium by through post-synthetic strategy, ACS Appl. Mater. Interfaces, 2016, 8, 31032-31041
11. Yabing Shan, Yiqun Liu, Li Yang, Honggang Nie，Sensen Shen, Chunxia Dong, Yu Bai, Qing Sun*, Jindong Zhao and Huwei Liu*, Lipid profiling of cyanobacteria synechococcussp. PCC 7002 using 2D LC-QToF-MS, J. Sep. Sci., 2016, 39, 3745-3753
12. Xin Wang, Alexandros Lamprou, Frantisek Svec*, Yu Bai, Huwei Liu*, Polymer-based Monolithic Column with Incorporated Chiral Metal-Organic Framework for Enantioseparation of Methyl Phenyl Sulfoxide Using Nano-Liquid Chromatography, J. Sep. Sci., 2016, 39, 4544–4548
13. 祁晓月，李先江，白玉，刘虎威*，手性金属有机骨架化合物的合成及其在对映异构体选择性分离中的应用，色谱，2016, 34, 10-15
14. Sensen Shen, Rui Weng, Linnan Li, Xinyuan Xu, Yu Bai*, Huwei Liu, Metabolomic Analysis of Mouse Embryonic Fibroblast Cells in Response to Autophagy Induced by Acute Starvation, Sci. Rep., 2016, 6
15. Rui Weng, Sensen Shen, Casey Burton, Li Yang, Honggang Nie, Yonglu Tian, Yu Bai* Huwei Liu, Lipidomic profiling of tryptophan hydroxylase 2 knockout mice reveals novel lipid biomarkers associated with serotonin deficiency, Anal. Bioanal. Chem., 2016, 408, 2963-2973
16. Wen Ma, Linnan Xu, Ze Li, Yunlong Sun, Yu Bai* and Huwei Liu, Post-synthetic modification of an amino-functionalized metal–organic framework for highly efficient enrichment of N-linked glycopeptides, Nanoscale, 2016, 8, 10908–10912
17. Wen Ma, Feng Zhang, Liping Li, Shuai Chen, Limin Qi, Huwei Liu, Yu Bai, Facile Synthesis of Mesocrystalline SnO2 Nanorods on Reduced Graphene Oxide Sheets: An Appealing Multifunctional Affinity Probe for Sequential Enrichment of Endogenous Peptides and Phosphopeptides, ACS Appl. Mater. Interfaces, 2016, 8, 35099-35105
18. Linnan Xu, Xiaoyue Qi, Xianjiang Li, Yu Bai*, Huwei Liu, Recent advances in applications of nanomaterials for sample preparation, Talanta, 2016, 146, 714–726
19. Linnan Xu, Wen Ma, Sensen Shen, Liping Li, Yu Bai* and Huwei Liu, Hydrazide functionalized monodispersed silica microspheres: a novel probe with tunable selectivity for a versatile enrichment of phosphopeptides with different numbers of phosphorylation sites in MS analysis, Chem. Commun., 2016, 52, 1162-1165
20. 聂洪港，花镇东，付晓芳*，白玉*, 常压敞开式质谱技术在新精神活性物质分析中的应用, 生命科学仪器, 2016 12-17
2015
1. Casey Burton, Rui Weng, Li Yang, Yu Bai*, Huwei Liu, Yinfa Ma*，High-throughput intracellular pteridinic profiling by liquid chromatography-quadrupole time-of-flight mass spectrometry, Anal. Chim. Acta, 2015, 853, 442–450
2. Ze Li, Yi-Wei Zhang, Yi-Ding Zhang, Yu Bai, Hu-Wei Liu*，Rapid analysis of four Sudan dyes using direct analysis in real time-mass spectrometry，Anal Methods, 2015, 7, 86–90
3. Cui-Lan Chang, Xiao-Yue Qi, Jiang-Wei Zhang, Ya-Ming Qiu, Xian-Jiang Li, Xin Wang, Yu Bai, Jun-Liang Sun and Hu-Wei Liu*, Facile synthesis of magnetic homochiral metal-organic frameworks for "enantioselective fishing'', Chem Comm, 2015, 51, 3566 - 3569
4. Xin Wang, Xianjiang Li, Yu Bai* and Huwei Liu*, Just dip it: Just dip it: online coupling of ‘‘Dip-it’’ polymer monolith microextraction with plasma assisted laser desorption ionization mass spectrometry, Chem Comm, 2015, 51, 4615-4618
5. Yiding Zhang, Linnan Li, Hexiang Huang, Linnan Xu, Ze Li, Yu Bai and Huwei Liu*, Binding constant determination of uranyl-citrate complex by ACE using a multi-injection method, Electrophoresis, 2015, 36, 1033–1039
6. Xianjiang Li, Xin Wang, Linnan Li, Yu Bai and Huwei Liu*, Direct Analysis in Real Time Mass Spectrometry: a Powerful Tool for Fast Analysis, Beijing National Laboratory for Molecular Sciences, Mass Spectrometry Letter, 2015, 6(1): 1-6
7. Li Yang, Xinge Cui, Ningning Zhang,Min Li, Yu Bai, Xiaohong Han, Yuankai Shi2, Huwei Liu1*, Comprehensive lipid profiling of plasma in patients with benign breast tumor and breast cancer reveals novel biomarkers, Anal Bioanal Chem, 2015, 407:5065–5077
8. Zhengxiang Zhang, Tao Bo, Yu Bai, Min Ye, Rong An, Fafeng Cheng, Huwei Liu,* Quadrupole time-of-flight mass spectrometry: powerful tool for demystifying traditional Chinese medicine, TrAC, accepted 2015-4-9
9. Rui Weng, Sensen Shen, Yonglu Tian, Casey Burton, Xinyuan Xu, Yi Liu, Cuilan Chang, Yu Bai, and Huwei Liu, Metabolomics Approach Reveals Integrated Metabolic Network Associated with Serotonin Deficiency, Scientific Reports, accepted, 2015-6-9
10. Yiding Zhang, Xianjiang Li, Honggang Nie, Li Yang, Ze Li, Yu Bai*, Li Niu, Daqian Song, Huwei Liu* An Interface for On-line Coupling of Surface Plasmon Resonance to Direct Analysis in Real Time Mass Spectrometry, Anal Chem,2015,87(13), 6505–6509
11. Rui Weng 1, Sensen Shen 1, Li Yang 1, Min Li 1, Yonglu Tian 2, Yu Bai 1* and Huwei Liu 1* Lipidomic analysis of p-chlorophenylalanine-treated mice using continuous-flow two-dimensional liquid chromatography/quadrupole time-of-flight mass spectrometry, Rapid Commun. Mass Spectrom., 2015, in press
12. Chang CL, Zhang JL, Li Z, Li LP, Xi LN, Li XJ, Fang BS, Bai Y and Liu HW*，Applications of Nanoparticles in Mass Spectrometry for Highly Sensitive Analysis, in Dr. Aliofkhazraei (Ed), Handbook of Nanoparticles, Springer-Verlag GmbH, 2015, https://meteor.springer.com/meteor/chapter/contribute.jsf?id=274
2014
1. Li M, Yang L, Bai Y, Liu HW*, Analytical Methods in Lipidomics and Their Applications, Anal. Chem. 2014, 86, 161-175
2. Li XJ, Xing JW, Chang CL, Wang X, Bai Y, Yan XP and Liu HW*, Solid-phase extraction with the metal-organic framework MIL-101(Cr) combined with direct analysis in real time mass spectrometry for the fast analysis of triazine herbicides, J. Sep. Sci., 2014, 37, 1489-1495
3. Wang X, Li XJ, Li Z, Zhang YD, Bai Yi and Liu HW*, Online Coupling of In-tube Solid Phase Microextraction with Direct Analysis in Real Time Mass Spectrometry for Rapid Determination of Triazine Herbicides by Using Polymer Monolith Incorporated with Single-Wall Carbon Nanotubes, Anal. Chem., 2014, 86, 4739−4747
4. Bai Y, Chang CL, Du FY, Tan ZL, Bai Y, Liu HW*, Combination of dynamic pH junction with capillary electrophoresis-mass spectrometry for the determination of systemins in plant samples,Electrophoresis, 2014, 35, 1984-1988
5. Li XJ, Chang CL, Wang X, Bai Y and Liu HW*, Applications of homochiral metal-organic frameworks in enantioselective adsorption and chromatography separation Electrophoresis, 2014, 35, 2733-2743
6. PangNN, Bai Y, Zhou Y, Yang X, Zhang ZX, Nie HG, Fu XF, Liu HW*, Rapid and subnanomolar assay of recombinant human erythropoietin by capillary electrophoresis using NanoOrange precolumn labeling and laser-induced fluorescence detection, J. Sep. Sci., 2014, 37, 2233-2238
7. Liu YQ, Zhang JL, Nie HG, Dong CX, Li Z, Zhang ZG, Bai Y, Liu HW* and Zhang JD*, Study on Variation of Lipids during Different Growth Phases of Living Cyanobacteria Using Easy Ambient Sonic-Spray Ionization Mass Spectrometry, Anal. Chem., 2014, 86, 7096-7102
8. Li Z, Zhang YW, Xin YL, Bai Y*, Zhou HH, Liu HW*，Lithium-rich composite metal oxide used as SALDI-MS matrix for the determination of small biomolecules, Chem, Comm., 2014, 50 (97),15397-15399
9. 冯鲍盛，白玉，刘虎威*， 实时直接分析质谱新技术及其应用，中国科学-化学（SCIENTIA SINICA Chimica），2014, 44(5): 784-788
10. Yang X, Pang NN, Fu XF, Yin HF, Liao YP, Liu HW*, Comparison of different derivatization procedures for analysis of recombinant human erythropoietin by capillary electrophoresis with laser-induced fluorescence detection, Journal of Chinese Pharmaceutical Sciences, 2014, 23 (5), 317-323
11. Liu HW, Chiral separations: methods and protocols, 2nd edition, Anal. Bioanal. Chem., 2014, 406, 11-12
12. Li LP, Xu LN, Li Z, Bai Y*, Liu HW, Novel nanomaterials used for sample preparation for protein analysis, Anal. Bioanal. Chem., 2014, 406, 35-47
13. Li LP, Chan S, Xi LN, Bai Y*, Bie ZX, Liu HW and Qi LM*, Template-free synthesis of uniform mesoporous SnO2 nanospheres for efficient phosphopeptide enrichment, J. Mat. Chem. B, 2014, 2,1121-1124
14. Feng BS, Zhang JL, Chang CL, Li LP, Li M, XIong, XC, Guo CG, Tang F, Bai Y*, and Liu HW, Mass Spectrometry Imaging of Traditional Chinese Medicine and Chinese Characters Using Plasma Assisted Multiwavelength Laser Desorption Ionization, Anal Chem., 2014, 86 (9), 4164–4169
15. Xu LN, Li LP, Jin L, Bai Y*, Liu HW, Guanidyl-functionalized graphene as a bifunctional adsorbent for selective enrichment of phosphopeptides, Chem, Comm., 2014, 50(75), 10963-10966
16. Li LP, Liu JZ, Xu LN, Li Ze, Bai Y*, Xiao YL, Liu HW, GdF3 as a promising phosphopeptide affinity probe and dephospho-labelling medium: experiments and theoretical explanation, Chem. Commun. 2014, 50(78), 11572-11575
17. Cao C, Zhang P, Li Z, Chan ZT, Huang YY, Bai Y* and Li XY*, A DNA-templated synthesis of encoded small molecules by DNA self-assembly, Chem. Commun. 2014, 50, 10997-10999
18. 张一丁，常翠兰，郭启雷，曹红，白玉*，刘虎威，檬黄铝色淀和日落黄铝色淀的毛细管区带电泳分析，色谱，2014, 32(4), 438-442
19. Li M, Tang XL, Lv Pm Fang BS, Yang L, Wu Z, Cui XG, Bai Y, Huang YN* and Liu HW*，A not-stop-flow online normal-/reversed-phase two-dimensional liquid chromatography-quadrupole time-of-flight mass spectrometry method for comprehensive lipid profiling of human plasma from atherosclerosis patients，J. Chromatogr. A, 2014, 1372, 110-119
20. 庞楠楠，聂洪港, 周宇，廖一平, 刘虎威*, 油酸氧化产的电喷雾离子化-离子阱-质谱裂解机理研究, 分析科学学报，2014, 30, 600-606
21. Han YH, Liu HW*, Separation and Detection of Jasmonic Acid in Plant Samples, in “Jasmonic Acid: Biosynthesis, Functions and Role in Plant Development”, Edited by Nadya Gotsiridze-Columbus,Nova Science Publishers, Inc., 2014., p15-32, Online: https://www.novapublishers.com/catalog/product_info.php?products_id=53267
2013
1 Cuilan Chang, Gege Xu, Yu Bai, Chengsen Zhang, Xianjiang Li, Min Li, Yi Liu, Huwei Liu, Online Coupling of Capillary Electrophoresis with Direct Analysis in Real Time Mass Spectrometry, Anal. Chem., 2013, 85 (1): 170–176
2 Liping Li, Tao Zheng, Linnan Xu, Ze Li, Lingdong Sun, Zongxiu Nie, Yu Bai, Huwei Liu, SnO2–ZnSn(OH)6: a novel binary affinity probe for global phosphopeptide detection, Chem. Commun., 2013, 49: 1762-1764
3 Liping Li, Baosheng Feng, Jianwang Yang, Cuilan Chang, Yu Bai, Huwei Liu, Applications of Ambient Mass Spectrometry in High-throughput Screening, Analyst, 2013, 138(11): 3097-3103,
4 Cuilan Chang, Li Qiaochu, Yu Bai, Dong Han, Gege Xu, Yiping Liao, Huwei Liu, Graphene matrix for signal enhancement in ambient plasma assisted laser desorption ionization mass spectrometry, Talanta, 2013, 114: 54-59
5 Min Li, Baosheng Feng, Yuan Liang, Wei Zhang, Yu Bai, Wen Tang, Tao Wang, Huwei Liu, Lipid profiling of human plasma from peritoneal dialysis patients using an improved 2D (NP/RP) LC-QToF MS method, Anal. Bioanal. Chem., 2013, 405: 6629–6638
6 Xin Wang, Qiao Ma, Min Li, Cuilan Chang, Yu Bai, Yuqi Feng, Huwei Liu, Automated and sensitive analysis of 28-epihomobrassinolide in Arabidopsis thaliana by on-line polymer monolith microextraction coupled to liquid chromatography-mass spectrometry，J. Chromatogr. A, 2013, 1317: 121–128
7 刘一，杨玉飞，廖一平，白玉，刘虎威, 铂类抗癌药物及其作用机理的分析技术进展, 化学通报，76， 10（2013）867-877
8 刘一，廖一平，白玉，刘虎威, α-乳清蛋白和β-乳球蛋白的毛细管区带电泳高效分离及高灵敏检, 分析化学 (Chinese Journal of Ananlytical Chemistry)，2013，41（10） 1597-1600,
9 Jialing Zhang, Zhigui Zhou, Jianwang Yang, Wei Zhang, Yu Bai, Huwei Liu, Thin Layer Chromatography/Plasma Assisted Multi-wavelength Laser Desorption Ionization Mass Spectrometry for Facile Separationmand Selective Identification of Low Molecular Weight Compounds, Anal. Chem. 2012, 84(3): 1496–1503
10 Zhigui Zhou, Youyou Yang, Jialing Zhang, Zhenxiang Zhang, Yu Bai, Yiping Liao, Huwei Liu, A Novel Membrane-Based Enzyme Micro-reactor Coupled Online with LC/QTOF MS for Protein Analysis, Anal. Bioanal. Chem., 2012, 403(1): 239-246
11 Jialing Zhang, Ze Li, Chengsen Zhang, Baosheng Feng, Zhigui Zhou, Yu Bai, Huwei Liu, Graphite Coated Paper as Substrate for High Sensitive Analysis in Ambient Surface-Assisted Laser Desorption/Ionization Mass Spectrometry, Anal Chem., 2012, 84 (7): 3296–3301
12 Yehua Han, Zhigui Zhou, Hongliang Wu, Honggang Nie, Rong Lei, Yu Bai, Huwei Liu, Determination of jasmonic acid epimers and their epimerization study by chiral liquid chromatography-mass spectrometry, J. Chromatogr. A, 2012, 1235: 125-137
13 Zhigui Zhou, Jialing Zhang, Jiawei Xing, Yu Bai, Huwei Liu, Membrane-based Continuous Remover of Trifluoroacetic Acid (TFA) in Mobile Phase for LC-ESI-MS Analysis of Proteins, J. Am. Soc. Mass Spectrom., 2012, 23(7): 1289-1292
14 Cuilan Chang, Xin Wang, Yu Bai, Huwei Liu, The applications of nanomaterials in enantioseparation and related techniques, Trend in Anal. Chem., TrAC, 2012, 39: 195–206
15 Cuilan Chang, Zhigui Zhou, Youyou Yang, Yehua Han, Yu Bai, Huwei Liu, Normal phase HPLC coupled with DART-MS for the chiral analysis of 4-(methylnitrosamino)-1- (3-pyridyl)-1-butanol and jasmonic acid, Electrophoresis, 2012, 33(22): 3387–3393
