姓名：杜琪珍

性别：男

学历：博士

职称：教授

工作单位：浙江农林大学

教育情况：

82年-86年: 湖南农业大学，园艺系，学士

86年-89年: 中国农业科学院研究生院，茶叶研究所，硕士，导师为李名君研究员

98年-00年: 浙江大学，化学工程系，博士，导师为吴平东教授

工作经历：

89年-98年：中国农业科学院茶叶研究所，生化研究室，助理研究员、副研究员(98)、副主任（97-99）

98年-99年： 美国北卡大学 (Chapel Hill)，化学系，访问学者

98年-00年：农业部茶叶化学工程重点实验室，副研究员、副主任 (98-99)

00年-01年：浙江工商大学，食品与生物工程学院，副研究员、研究员 (01)

01年-03年：德国不伦瑞克工业大学，药物与化学系，洪堡学者

03年-14在：浙江工商大学，食品与生物工程学院，研究员、西湖学者，博士生导师，食品与生物工程研究所副所长，食品化学研究所所长

14年-      浙江农林大学，农业与食品科学学院，研究员，食品科学与工程学科带头人

所受奖项：

① 浙江省科技进步一等奖, “三种植物源天然活性物质制备技术研究及产业化”，2010，第2。

② 浙江省科技进步三等奖, “果类植物及废弃物中天然多酚活性物制备关键技术及产业化”，2011，第11。

③ Edward Chou Award（逆流色谱协会最高奖），2006，个人。

④ 中国农业科学院科技成果二等奖，“低速逆流色谱分离技术及其应用”，2001，第1。

⑤ 农业部科技进步二等奖， “茶儿茶素等有效成分分离、应用及新型茶加工技术”，1996，第3。

主要研究方向：

食品化学与营养

食品安全

天然产物活性筛选

代表性著作：

Min Wu, Jianchang Jinb, Peng Jin，Yongquan Xu, Junfeng Yin, Dingkui Qin, Kai Wang, Qizhen Du* (2017). Epigallocatechin gallate-β-lactoglobulin nanoparticles improve the antitumor activity of EGCG for inducing cancer cell apoptosis, Journal of Functional Foods, 39, 257-263.

Yuanyuan Yang, Peng Jin，Xingcai Zhang, Nagaiya Ravichandran, Hao Ying, Chenghuan Yu, Huazhong Ying, Yongquan Xu, Junfeng Yin, Kai Wang，Ming Wu, Qizhen Du* (2017). New Epigallocatechin Gallate (EGCG) Nanocomplexes Co-Assembled with 3-Mercapto-1-Hexanol and β-Lactoglobulin for Improvement of Antitumor Activity, Journal of Biomedical Nanotechnology, 13, 805-814.

Weihua Zhang, Binqwu Liao, Yuanyuan Yang, Tao Lv, Zhaoyang Fan, Yongquan Xu, Junfeng Yin, Hao Yinq, Nagaiya Ravichandran, Qizhen Du* (2017). Sucrose esters improve the colloidal stability of nanoethosomal suspensions of (-)-epigallocatechin gallate for enhancing the effectiveness against UVB-induced skin damage, Journal of Biomedical Materials Research B: Applied Biomaterials 105(8):2416-2425.

Qizhen Du, Yongchun Zhao, Hongchun Liu, Chunping Tang, Minmin Zhang, Changqiang Ke, Yang Ye* (2017). Isolation and Structure(haracterization of Cytotoxic Phorbol Esters from the Seeds of Croton tiglium, Planta Medica, 83:1361-1367.

B Liao，H Ying，C Yu，Z Fan，W Zhang，J Shi，H Ying，N Ravichandran，Y Xu, J Yin, Y Jiang, Q Du* (2016). (-)-Epigallocatechin gallate (EGCG)-nanoethosomes as a transdermal delivery system for docetaxel to treat implanted human melanoma cell tumors In mice. International Journal of Pharmaceutics, 512:22-31.

Yong-Quan Xu, Xiong-Fei Hu, Ping Tang, Yong-Wen Jiang, Hai-Bo Yuan, Qi-Zhen Du*, Jun-Fens Yin (2015). The major factors influencing the formation of sediments in reconstituted green tea infusion, Food Chemistry, 772, 837-835.

Zhiyong Hong, Yongquan Xu, Jun-Feng Yin, Jianchang Jin, Yongwen Jiang, Qizhen Du* (2014). Improving the Effectiveness of (−)-Epigallocatechin Gallate (EGCG) against Rabbit Atherosclerosis by EGCG-Loaded Nanoparticles Prepared from Chitosan and Polyaspartic Acid, Journal of Agricultural and Food Chemistry 12603−12609.

Ying, H., Liu, J., Du, Q. * (2014). Analysis and determination of oestrogen-active compounds in fructusamomi by the combination of high-speed counter-current chromatography and high performance liquid chromatography, Journal of Chromatography B, 958:36-42.

Ying, H., Jiang, H.,  Liu, H., Chen, F., Du, Q.  (2014). Ethyl acetate–n- butanol gradient solvent system for high-speed countercurrent chromatography to screen bioactive substances in okra．Journal of Chromatography A, 1359, 117-123．

Yin, J., Zhang, Y., Du, Q.*, J. Chen, Yuan, H., Xu, Y. (2014). Effect of Ca²⁺ concentration on the tastes from the main chemicals in green tea infusions. Food Research International 62, 941–946.

Xu, Y., Chen, G.-S., Du, Q.*, Que, F., Yuan, H., Yin, J. (2014). Sediments in concentrated green tea during low-temperature storage. Food Chemistry 149, 137-143.

Xu, Y., Zhong, X., Yin, J., Yuan, H., Tang, P., Du, Q.* (2013) The impact of Ca 2⁺ combination with organic acids on green tea infusions. Food Chemistry 139, 944–948.

He, M., Du, W., Du, Q., Zhang, Y., Li, B., Ke, C., Ye, Y., Du, Q.* (2013) Isolation of the retinal isomers from the isomerization of all-trans-retinal by flash countercurrent chromatography. Journal of Chromatography A, 1271, 67–70.

Qingbao Du, Q., Jiang, H., Yina, J., Xua, Y., Dua, W., Lia, B. Du, Q.* (2013) Scaling up of high-speed countercurrent chromatographic apparatus with three columns connected in series for rapid preparation of (–)-epicatechin. Journal of Chromatography A, 1271, 62–66.

Jin, Y., Qian, D., Du, Q.* (2013) Preparation of bioactive amide compounds from black pepper by countercurrent chromatography and preparative HPLC, Industrial Crops & Products. 44, 258–262.

Li, B., Du, W., Jin, J., Du, Q.* (2012) Preservation of (-)-epigallocatechin-3-gallate antioxidant properties loaded in heat treated β-lactoglobulin nanoparticles. Journal of Agricultural and Food Chemistry, 60, 3477-3484.

Song, G., Du, Q. (2012) Structure characterization and antitumor activity of an α β-glucan polysaccharide from Auricularia polytricha, Food Research International, 45, 381-387.

Li, B., Du, W., Qian, D., Du, Q.* (2012) Combination of high-speed countercurrent chromatography and reversed phase C18 chromatography for large-scale isolation of cyanidin-3-O-β-d-glucoside from black rice bran extract. Industrial Crops and Products, 37, 88-92.

Qiao, Q., Du, Q.*, Chen, H. (2012), Identification of antioxidant compounds of Mucuna sempervirens by high-speed counter-current chromatographic separation–DPPH radical scavenging detection and their oestrogenic activity, Food Chemistry 131, 1181-1186.

Fu, X., Du, Q.* (2011), Uptake of Di-(2-ethylhexyl) phthalate of vegetables from plastic film Greenhouses, Journal of Agricultural and Food Chemistry 59, 11585-11588.

Jiang Z., Du, Q. * (2011) Glucose-lowering activity of novel tetrasaccharide glyceroglycolipids from the fruits of Cucurbita moschata, Bioorganic & Medicinal Chemistry Letters, 21, 1001-1003.

Qiao Q., Du, Q. * (2011) Preparation of the monomers of gingerols and 6-shogaol by flash high speed counter-current chromatography, Journal of Chromatography A, 1218, 6187-90.

Xu, M., Shen, L., Wang, K., Du, Q. (2011) Two New Abietane Diterpenoids from the Stems of Clerodendrum kaichianum P.?S. Hsu, Helvetica Chimica Acta, 94, 539-544.

Du, Q.* Wang, J., Fu, X., Xia, H. (2010) Diffusion and accumulation in cultivated vegetable plants of di-(2-ethylhexyl) phthalate (DEHP) from a plastic production factory, Food Additives and Contaminants, 27, 1186-1192.

Song, G., Du, Q.* (2010) Isolation of a polysaccharide with anticancer activity from Auricularia polytricha using high-speed countercurrent chromatography with an aqueous two-phase system, Journal of Chromatography A 1217, 5930-5934.

Wang, K., Zhang, H., Shen, L., Du, Q., Li, J. (2010) Rapid separation and characterization of active flavonolignans of Silybum marianum by ultra-performance liquid chromatography coupled with electrospray tandem mass spectrometry, Journal of Pharmaceutical and Biomedical Analysis 53, 1053-1057.

Shen, L., Su, G., Wang, X., Du, Q., Wang, K. (2010) Endogenous and exogenous enzymolysis of vegetable-sourced glucosinolates and influencing factors, Food Chemistry, 119, 987-994.

Du, Q. *, Hui Chen (2010) The methoxyflavones in Citrus reticulata Blanco cv. Ponkan and their antiproliferative activity against cancer cells, Food Chemistry, 119, 567-572.

Du, Q.*, Jiang, Z., Wang, D. (2009) Excellent combination of counter-current chromatography and preparative high-performance liquid chromatography to separate galactolipids from pumpkin, Journal of Chromatography A, 1216, 4176-4180.

Du, Q.Z.*, Fu, X.W., Xia, H.L. (2009) Uptake of di-(2-ethylhexyl)phthalate from plastic mulch film by vegetable plants, Food Additives & Contaminants, 26,1325-1329.