食品中硝基呋喃类药物残留检测技术的研究进展
Research progress on determination techniques of nitrofurans in food
投稿时间:2023-12-21  修订日期:2024-02-05
DOI:
中文关键词:  硝基呋喃类药物  硝呋索尔  代谢物  食品  检测方法
英文关键词:nitrofurans  nifursol  metabolites  food  determination techniques
基金项目:国家重点研发计划青年科学家项目(2022YFF1102500)、国家市场监管重点实验室(动物源性食品中重点化学危害物检测技术)开放课题(KF-202203)、武汉轻工大学科研项目(2023Y11)
作者单位
胡家勇 国家市场监管重点实验室(动物源性食品中重点化学危害物检测技术) 
柳鑫 武汉轻工大学食品科学与工程学院 
张莉 国家市场监管重点实验室动物源性食品中重点化学危害物检测技术 
刘言 武汉轻工大学食品科学与工程学院 
王桥 武汉轻工大学食品科学与工程学院 
李玉芝 国家市场监管重点实验室动物源性食品中重点化学危害物检测技术 
宫智勇 武汉轻工大学食品科学与工程学院 
AuthorInstitution
HU Jia-Yong Key Laboratory of Detection Technology of Focus Chemical Hazards in Animal-derived Food for State Market Regulation 
LIU Xin School of Food Science and Engineering,Wuhan Polytechnic University 
ZHANG Li Key Laboratory of Detection Technology of Focus Chemical Hazards in Animal-derived Food for State Market Regulation 
LIU Yan School of Food Science and Engineering,Wuhan Polytechnic University 
WANG Qiao School of Food Science and Engineering,Wuhan Polytechnic University 
LI Yu-Zhi Key Laboratory of Detection Technology of Focus Chemical Hazards in Animal-derived Food for State Market Regulation 
GONG Zhi-Yong School of Food Science and Engineering,Wuhan Polytechnic University 
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中文摘要:
      摘 要:硝基呋喃类抗菌药因价格便宜、抗菌效果好,曾被广泛应用于畜禽水产等养殖行业。其代谢物可在动物体内长时间残留,对人体有强毒性和潜在的致畸致癌致突变风险,对此各国已出台限量标准和管控政策。本文介绍了5种硝基呋喃类原药(含硝呋索尔)及其代谢物的理化性质;色谱技术、液相色谱-质谱联用技术和免疫学技术等常用检测技术在近三年的研究进展,比较了各方法的前处理技术和检测技术的特点及检测效果;着重介绍了表面增强拉曼、电化学传感、基于金属有机框架的荧光传感等新型快速检测技术的发展,从材料设计和检测方法等方面归纳比较。并就硝基呋喃类药残的检测技术和监管措施进行了展望,以期为硝基呋喃类药物及其代谢物的检测、监管等提供新思路。
英文摘要:
      ABSTRACT: Nitrofuran antibiotics had been widely used in livestock, poultry, and aquaculture industries because of their low-cost and good antibacterial effects. Nowadays, nitrofurans are banned in countries due to their intense toxicity and potential risks of teratogenicity, cancer, and mutation to humans. This article reviews the physicochemical properties of five nitrofurans (including nifursol) and their metabolites; the research progress of commonly used detection techniques such as chromatography, liquid chromatography-mass spectrometry, and immunology in the past three years was compared in terms of pre-treatment techniques and detection effectiveness; the development of rapid detection methods such as surface enhanced Raman spectroscopy, electrochemical sensing, and fluorescence sensing technology based on metal organic frameworks were emphasized and summarized through materials’ design and detection technique. The paper also made prospects for the detection technology and regulatory measures of nitrofuran residues, in order to provide new ideas for the detection and regulation of nitrofuran metabolites.
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