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| 低聚木糖的毒理学安全性研究 |
| Research on the Toxicological Safety of Xylooligosaccharides |
| 投稿时间：2025-02-28 修订日期：2025-06-03 |
| DOI： |
| 中文关键词: 低聚木糖 急性毒性 遗传毒性 亚急性毒性 安全评价 |
| 英文关键词:xylooligosaccharides acute toxicity genotoxicity subacute toxicity safety evaluation |
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| 中文摘要: |
| 目的 评价低聚木糖的毒理学安全性。方法 依据食品安全国家标准,通过小鼠急性经口毒性试验、哺乳动物骨髓红细胞微核试验、精母细胞染色体畸变试验、细菌回复突变(Ames)试验、28天经口毒性试验对其进行安全性评价。结果 低聚木糖对雌雄小鼠急性经口最大耐受剂量(MTD)均大于10000 mg/kg.bw,属实际无毒级；哺乳动物骨髓红细胞微核试验、精母细胞染色体畸变试验和细菌回复突变(Ames)试验试验均为阴性；设0(基础饲料对照)、4167、8333、16667mg/kg b.wt.三个剂量组(相当于最大推荐摄入量的25、50和100倍) ,每日经口灌胃一次,连续28天。高剂量组动物出现与受试样品相关的总增重降低,ALT、ALP、GLU及BUN等生化指标改变,雄性大鼠部分脏器重量及脏体比减少等变化,而中、低剂量组(相当于最大推荐摄入量的50倍和25倍)以及卫星组未见相应变化。结论 低聚木糖未显示急性毒性、遗传毒性；该样品对雌、雄大鼠28天经口毒性未观察到有害作用剂量(NOAEL)为8333mg/kg b.wt.。 |
| 英文摘要: |
| Objective: Evaluate the toxicological safety of xylooligosaccharides.Methods: According to the national food safety standards, the safety of xylooligosaccharides was evaluated through acute oral toxicity test in mice, micronucleus tests in mammalian bone marrow red blood cells, chromosomal aberration tests in spermatocytes, Bacterial reverse mutation (Ames) test, and 28 day oral toxicity test.Results: The acute maximum tolerated dose (MTD) of xylooligosaccharides in male and female mice is greater than 10000 mg/kg ? bw, which is classified as practically non-toxic; The micronucleus test of mammalian bone marrow red blood cells, chromosome aberration test of spermatocytes, and Ames test were all negative; Set up three dose groups: 0 (basic feed control), 4167, 8333, and 16667mg/kg b.wt. (equivalent to 25, 50, and 100 times the maximum recommended intake), orally administered once a day for 28 consecutive days. The high-dose group of animals showed a decrease in total weight gain related to the test sample, changes in biochemical indicators such as ALT, ALP, GLU, and BUN, and a decrease in organ weight and visceral to body ratio in male rats. However, there were no corresponding changes observed in the medium and low-dose groups (equivalent to 50 times and 25 times the maximum recommended intake) and the Weixing group.Conclusion:Xylooligosaccharides did not show acute toxicity or genetic toxicity; The NOAEL (No Adverse Effect Level) of the sample for 28 days of oral toxicity in female and male rats was 8333mg/kg b.wt.。 |
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