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| 乳制品中磺胺类药物残留检测研究进展 |
| Research progress on the detection of sulfonamide drug residues in dairy products |
| 投稿时间：2025-01-20 修订日期：2025-05-09 |
| DOI： |
| 中文关键词: 磺胺类药物 乳制品检测 色谱-质谱联用 样品处理 固相萃取 |
| 英文关键词:Sulfonamide drugs Dairy product detection Chromatography-mass spectrometry Sample pretreatment Solid-phase extraction |
| 基金项目:2024年度陕西省市场监督管理局科技计划项目(2024KY03)；国家资助博士后研究人员计划(GZC20231513) |
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| 中文摘要: |
| 磺胺类药物作为常用的兽用抗菌药，检测其在乳制品中的残留对保障食品安全和公众健康至关重要。色谱-质谱联用技术因其高灵敏度和优异的选择性，是乳制品中磺胺类药物的检测的主要方法。本文综述了该技术在磺胺类药物检测中的应用进展，重点讨论了样品前处理方法、色谱条件优化及质谱分析技术的改进。此外，结合微流体技术、分子印迹聚合物以及3D打印技术等新兴手段，探索了这些技术如何在提高检测效率、降低成本和简化操作方面发挥作用。未来对于药物残留检测的研究重点在于低成本的快速方便检测，本文对该领域的研究提供了一定的参考思路。 |
| 英文摘要: |
| As widely used veterinary antimicrobials, sulfonamides are essential to detect in dairy products to protect public health and food safety. Chromatography-mass spectrometry (LC-MS) is the main technique for detecting sulfonamides in dairy products because of its high sensitivity and excellent selectivity. This paper reviewed the development of this technique in sulfonamide detection, focusing on improvements in sample pretreatment methods, chromatographic condition optimization, and advancements in mass spectrometry techniques. It also examined the roles of emerging technologies like microfluidics, molecularly imprinted polymers, and 3D printing in improving detection efficiency, cutting costs, and streamlining operations. Future research in drug residue detection will be centered on quick and economical methods, and this review offers useful information for that research field. |
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