β-环糊精纳米海绵的制备及丹皮酚负载效果研究

Research on preparation of β-cyclodextrin nanosponge and paeonol loading effects

中文关键词:  纳米海绵  β环糊精  活性物质  负载  多孔材料

英文关键词:nanosponge  β-cyclodextrin  active substance  load  porous material

中文摘要:

      目的 制备一种β-环糊精纳米海绵, 并探究丹皮酚负载效果。方法 通过交联法制备环糊精纳米海绵, 采用红外光谱法检测、X射线衍射和热重分析, 判断交联效果, 通过扫描电子显微镜分析纳米海绵形貌和孔隙状态。采用浸泡法将丹皮酚负载于纳米海绵中, 使用液相色谱法检测分析负载效果。结果 从红外光谱法分析可知交联反应获得了6种纳米海绵, 原β-环糊精晶体结构因为生成新的产物而消失。纳米海绵热稳定性相比β-环糊精有所下降, 获得3种孔隙形貌相对完整和均匀的纳米海绵, 其对丹皮酚的负载率分别为19.31%、12.27%、5.78%。结论 合成的多孔纳米海绵负载丹皮酚效果较好, 可以应用在食品或生鲜产品的活性包装中。

英文摘要:

      Objective To prepare a kind of β-cyclodextrin nanosponge and explore the paeonol loading effects. Methods The cyclodextrin nanosponge was prepared by cross-linking, the cross-linking effect were determined through infrared spectrum detection, X-ray diffraction and thermogravimetric analysis, and the morphology and pore state of nanosponge was analyzed with the scanning electron microscope; the paeonol was loaded onto the nanosponge by immersion, and the loading effect was analyzed through liquid chromatography detection. Results Through the infrared spectroscopic analysis, 6 kinds of nanosponge were produced successfully after the cross-linking reaction; the original crystalline structure of β-cyclodextrin disappeared due to the formation of new products; nanosponge had a lower thermal stability than of β-cyclodextrin; 3 kinds of nanosponge with relatively complete and uniform pore structure were produced, and their paeonol loading rates were 19.31%, 12.27% and 5.78% respectively. Conclusion The produced porous nanosponge has good paeonol loading effect, and can be used in the active packages of food or fresh products.