后生元粉在高尿酸血症中的降尿酸效果研究

Study on the uric acid-lowering effects of postbiotic powder in hyperuricemia

中文关键词:  后生元，高尿酸血症，黄嘌呤氧化酶，尿酸

英文关键词:postbiotic  hyperuricemia  xanthine oxidase  uric acid

中文摘要:

      目的 探究复合后生元粉在高尿酸血症中的降尿酸效果。方法 在体外实验中验证后生元粉具有抑制黄嘌呤氧化酶(xanthine oxidase, XOD)活性和降解尿酸两种功效, 建立大鼠高尿酸血症模型, 并给予后生元粉治疗, 分别对比了大鼠体重变化、关节增长情况、血清尿酸(uric acid, UA)含量、血清XOD活力、肝肾功能、血脂总胆固醇(total cholesterol, TC)、甘油三酯(triglyceride, TG)水平等指标的变化。结果 复合后生元粉能显著降低高尿酸血症大鼠血清UA的含量以及血清尿素氮(blood urea nitrogen, BUN)、肌酐(creatinine, Cr)和TC水平; 能够有效降低血清XOD、谷草转氨酶(aspartate aminotransferase, AST)、谷丙转氨酶(alanine aminotransferase, ALT)活力。结论 后生元粉具有降UA功效, 对高尿酸血症引起的肝、肾损伤和血脂异常也有一定的治疗作用, 并且治疗效果与后生元粉的摄入量呈正相关。

英文摘要:

      Objective To investigate the uric acid-lowering effects of compound postbiotic powder in hyperuricemia. Methods In vitro experiments verified that the metabiotic powder had 2 kinds of effects: Inhibiting xanthine oxidase (XOD) activity and degrading uric acid, and then establishing a rat hyperuricemia model, and giving postbiotic powder treatment, respectively, the changes in body weight, joint growth, serum uric acid (UA) content, serum XOD activity, liver and kidney function, and total cholesterol (TC) in blood lipids, triglyceride (TG) level were compared. Results The sample significantly reduced the serum UA content, serum urea nitrogen (BUN), creatinine (Cr) and TC levels in rats with hyperuricemia. It could effectively reduce the activities of serum XOD, aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Conclusion Postbiotic powder has the effect of lowering uric acid, and also has a certain therapeutic effect on liver and kidney injury and dyslipidemia caused by hyperuricemia, and the therapeutic effect is positively correlated with the intake of postbiotic powder.