苯并三唑类有机紫外吸收剂的健康风险研究现状

Research status of health risks of benzotriazole ultraviolet absorbents

中文关键词:  苯并三唑类有机紫外吸收剂  环境暴露  人体暴露  毒性

英文关键词:benzotriazole ultraviolet absorbents  environmental exposure  human exposure  toxicity

中文摘要:

      苯并三唑类有机紫外吸收剂(benzotriazole ultraviolet absorbers, BUVs)是一类新型的持久性有机污染物, 因良好的紫外线吸收能力和热稳定性, 作为光稳定剂广泛应用于各类工业产品, 其中2-(3,5-二叔戊基-2-羟苯基)苯并三唑[2-(2H-benzotriazol-2-yl)-4,6-di-tert-pentylphenol, UV-328]已被列入《斯德哥尔摩公约》管控中。当前, 国内外研究已有大量关于BUVs在环境和生物体内的暴露情况, 沉积物和土壤中BUVs浓度普遍达到数百ng/g, 水体和鱼类中检出频繁。人类通过膳食摄入和呼吸道摄入存在暴露风险, 目前人类尿液和血液中BUVs负荷报道不多, 值得关注的是人类母乳中BUVs负荷水平, 最高可达上千ng/g。鉴于BUVs的生物积累性和潜在毒性, 本文详细综述了各类环境、生物和人体组织样本中BUVs暴露情况, 并对其肝肾靶器官毒性、内分泌干扰效应和免疫、神经毒性等潜在危害作简要总结, 旨在为BUVs在人体中的健康风险评估提供参考。

英文摘要:

      Benzotriazole ultraviolet absorbers (BUVs) are a new class of persistent organic pollutants, which are widely used as light stabilizers in various industrial products with good ultraviolet absorbing ability and thermal stability, among which 2-(2H-benzotriazol-2-yl)-4,6-di-tert-pentylphenol (UV-328) has been listed in the Stockholm Convention. Currently, there are a large number of domestic and international studies on the exposure of BUVs in the environment and living organisms, and the concentration of BUVs in sediments and soils generally reaches hundreds of ng/g, and they are frequently detected in water bodies and fish. Humans have an exposure risk through dietary intake and respiratory tract intake, but there are few reports on the load of BUVs in human urine and blood, and it is noteworthy that the load of BUVs in human breast milk can reach up to thousands of ng/g. In view of the bioaccumulation and potential toxicity of BUVs, this paper provided a detailed overview of the exposure to BUVs in various types of environmental, biological, and human tissue samples. This paper briefly summarized the potential hazards of BUVs, such as liver and kidney target organ toxicity, endocrine disrupting effects, and immunotoxicity and neurotoxicity, aiming to provide a reference for the assessment of the health risk of BUVs in human beings.