类黄酮化合物纳米递送系统研究进展

Research progress of flavonoid nanodelivery system

中文关键词:  类黄酮  纳米载体  递送系统  疾病

英文关键词:flavonoids  nanocarriers  delivery system  illness

中文摘要:

      类黄酮是植物中特有的化学物质, 在自然界中广泛存在, 具有抗氧化、抗炎、抗癌等生物学作用。然而, 其作用效果一直受到生物利用度低和药代动力学差的影响, 限制了体内生物学作用。解决这些问题的方法之一是通过纳米载体改善类黄酮在体内的稳定性和生物利用度, 减少有效成分在体内运输过程中分解, 纳米载体的应用使类黄酮在体内的运输具有靶向性, 能够将类黄酮准确递送至相应靶点, 减少其毒性和不良反应, 提高其作用效果。本文结合近几年类黄酮化合物纳米递送系统的研究进展, 重点对类黄酮纳米载体类型及其在疾病中的应用进行了归纳总结, 以期为深入开发应用类黄酮化合物提供新的思路。

英文摘要:

      Flavonoids are unique chemical substances found in plants and are widely present in nature and have biological effects such as antioxidant, anti-inflammatory, and anticancer. However, its efficacy has always been affected by low bioavailability and poor pharmacokinetics, limiting its in vivo biological effects. One of the methods to solve these problems is to improve the stability and bioavailability of flavonoids in vivo through nanocarriers, reduce the decomposition of active ingredients during transportation in vivo. The application of nanocarriers makes the transportation of flavonoids in vivo targeted, accurately delivering flavonoids to corresponding targets, reducing their toxicity and adverse reactions, and improving their effectiveness. This article combined the research progress of flavonoid nanocarriers in recent years, focusing on summarizing the types of flavonoid nanocarriers and their applications in diseases, in order to provide new ideas for the in-depth development and application of flavonoid compounds.