沙门氏菌耐药与毒力杂合质粒的分子特征与转移风险研究进展

Research progress on molecular characteristics and transfer risks of hybrid resistance and virulence plasmids in Salmonella

中文关键词:  沙门氏菌  杂合型质粒  耐药  毒力  可移动元件

英文关键词:Salmonella  hybrid plasmids  resistance  virulence  mobile genetic elements

中文摘要:

      沙门氏菌是引发食物中毒的首要致病细菌, 其高毒耐药流行株在食品安全研究领域受到广泛关注。这些高毒耐药株中常携带耐药与毒力基因杂合质粒及大量可移动元件, 它们可通过整个食品产业链进行水平转移, 给民众的餐桌安全和身体健康带来巨大危害。深入解析这些质粒中耐药与毒力基因杂合转移的分子特征及其转移风险, 是研究食源性致病菌危害因子传播规律领域的一个重要问题。伴随着测序技术的进步, 耐药与毒力基因在质粒中的聚集与重组等演化过程逐渐被揭示, 可移动元件在质粒的稳定和转移过程中的作用也得到初步验证。基于此, 本文从杂合方式与转移风险、重要可移动元件的功能以及杂合质粒中耐药与毒力基因的演化特征等角度, 简述沙门氏菌耐药与毒力杂合质粒的研究进展, 以期为揭示高毒耐药株的传播特征和风险评估提供数据支持。

英文摘要:

      Salmonella is the leading pathogenic bacteria causing food poisoning, and its high virulent resistant strains have received widespread attention in researches on food safety. These high virulent resistant strains often carry hybrid plasmids of resistance and virulence genes, as well as a large number of mobile elements, which can be horizontally transferred through the entire food chain, posing a huge threat to the safety and health of the public’s dining tables. The in-depth analysis of the molecular characteristics and transfer risks of heterologous resistance and virulence genes in these hybrid plasmids will be an important issue to studying the transmission patterns of harmful factors of foodborne pathogens. With the advancement of sequencing technology, the aggregation and recombination of resistance and virulence genes in plasmids and their evolutionary law have gradually been revealed, and the role of mobile elements in the stability and transfer of plasmids has also been preliminarily verified. Based on these researches, this article briefly described the research progress of hybrid resistance and virulence plasmids in Salmonella from the perspectives of hybrid modes and transfer risks, the functions of important mobile genetic elements, and the evolutionary characteristics of resistance and virulence genes in hybrid plasmids. The aim is to provide data support for revealing the transmission characteristics and risk assessment of high virulent resistant epidemic strains.