婴儿配方奶粉中3种新型溴代阻燃剂参考物质候选物的研制

Development of reference material candidates for 3 kinds of novel brominated flame retardants in infant formula milk powders

中文关键词:  婴儿配方奶粉  新型溴代阻燃剂  参考物质候选物  食品污染物

英文关键词:infant formula milk powders  novel brominated flame retardants  reference material candidates  food contaminates

中文摘要:

      目的 研制婴儿配方奶粉中五溴甲苯、六溴苯和1,2-双(2,4,6-三溴苯氧基)乙烷3种新型溴代阻燃剂的参考物质候选物。方法 以市售婴儿配方奶粉为研究基质, 经加水溶解、标准添加、均质、干燥、粉碎、筛分和分装等工序制备后, 用同位素稀释-大气压气相色谱-串联质谱法进行目标物的均匀性检验和稳定性考察。分别采用F检验和一元线性模拟方程评价参考物质候选物的均匀性和稳定性数据。结果 均匀性检验的分析结果显示3种新型溴代阻燃剂的F均小于临界值F (1.964)。稳定性考察的分析结果显示, 在40℃放置10 d或–20℃避光放置6个月的条件下, 候选物的特性量值未观测到明显变化。结论 本研究研制的婴儿配方奶粉中3种新型溴代阻燃剂参考物质候选物的均匀性、稳定性良好, 符合参考物质的预期要求, 能够为进一步形成参考物质提供物质基础。

英文摘要:

      Objective To prepare a reference material candidate for 3 kinds of novel brominated flame retardants, including pentabromotoluene, hexabromobenzene and 1,2-bis(2,4,6-tribromophenoxy)ethane, in infant formula milk powders. Methods Commercial infant formula milk powders were used as the research matrix, and prepared through processes such as water dissolution, standard addition, homogenization, drying, crushing, screening and packaging. After that, the homogeneity and stability of the target compounds were inspected by isotope dilution-atmospheric pressure gas chromatography-tandem mass spectrometry. The F-test and univariate linear regression model were used to evaluate the homogeneity and stability data, respectively. Results The results of the homogeneity analysis showed the F of 3 kinds of new brominated flame retardants were less than the critical value F (1.964). The results of the stability monitoring indicates that no significant alteration was observed for the concentrations of target compounds in reference material candidates stored at 40℃ for 10 days, or at –20℃ away from light for 6 months. Conclusion The reference material candidates for 3 kinds of novel brominated flame retardants in infant formula milk powders developed in this study have good homogeneity and stability, which meet the expected requirements of reference materials, and can be used as substance bases for the further development of corresponding reference materials.