硅橡胶奶嘴中挥发性物质成分分析

Compositional analysis of volatile substances in silicone rubber nipple

中文关键词:  非靶向筛查  硅橡胶奶嘴  挥发性物质  残留物溯源  婴幼儿食品安全  毒理学关注阈值法

英文关键词:Non-targeted screening technology  Silicone rubber nipple  Volatile substances  Residue traceability  Infant food safety  Headspace-gas chromatography-mass spectrometry  Threshold of toxicological concern method

中文摘要:

      目的 溯源分析婴幼儿硅橡胶奶嘴的挥发性物质成分, 评估健康风险。方法 采用顶空气相色谱-质谱法挥发性物质非靶向筛查技术, 分析挥发性物质总含量大于0.5%的硅橡胶奶嘴样品, 通过100%迁移计算得到可能的最大迁移量。结果 所测5种不合格硅橡胶奶嘴共检出16种挥发性有机物, 包括环状/线性硅氧烷、醇类、醛类和芳香类物质。不同品牌奶嘴残留的挥发性物质种类区别较大。选择(+)-柠檬烯和正十三烷作为内标物进行半定量, 依据标准限量和毒理学关注阈值法评估检出物的食品安全风险; 多种硅氧烷的暴露量超过安全暴露阈值, 需引起健康风险关注, 特别是具有生物累积性的八甲基环四硅氧烷和十甲基环五硅氧烷。结论 本研究开发的挥发性物质筛查和评估方法, 适用于婴幼儿奶嘴的食品安全评价, 样品检测结果表明, 婴幼儿硅橡胶奶嘴中挥发性物质安全性需引起关注。

英文摘要:

      Objective To traceably analyze the volatile substances in infant silicone rubber nipple, and assess health risks. Methods Headspace gas chromatography-mass spectrometry non-targeted screening technology for volatile substances was used to analyze silicone rubber nipple for infants and young children with a total volatile substance content greater than 0.5%, and the maximum possible migration amount was calculated through 100% migration. Results A total of 16 kinds of volatile organic compounds were detected in the 5 unqualified silicone rubber nipples tested, including cyclic/linear siloxanes, alcohols, aldehydes, and aromatic substances. The types of volatile substances remaining in pacifiers of different brands vary greatly. (+)-Limonene and n-tridecane were selected as internal standards for semi-quantification, and the food safety risks of the detected substances were assessed based on the standard limits and toxicological concern threshold methods; the exposure amounts of various siloxanes exceeded the safe exposure thresholds and required raising health risk concerns, particularly for octamethylcyclotetrasiloxane and decamethylcyclopentasiloxane, which were bioaccumulative. Conclusion The screening and evaluation method of volatile substances developed in this study is suitable for food safety evaluation of infant pacifiers. The results of sample testing show that the safety of volatile substances in infant silicone rubber pacifiers needs attention.