β-葡聚糖增强肠道免疫功能研究进展

Research progress on enhancing intestinal immune function of beta-glucan

中文关键词:  β-葡聚糖  食物过敏  肠道屏障  肠道菌群  

英文关键词:beta-glucan  immunoregulation  intestinal barrier  intestinal flora

中文摘要:

      肠道既是机体营养物质消化吸收的重要场所, 又是防御外界病原体等的重要屏障, 维持肠道稳态、增强肠道免疫功能对于保持机体健康至关重要。β-葡聚糖作为一种膳食纤维, 同时也被列为益生元, 具有众多生物活性和较强的免疫活性, 如免疫调节、抗菌、抗炎等, 尤其是可以通过直接或间接(肠道代谢物)途径参与重塑肠道菌群组成及比例, 维持与修复肠道屏障完整性, 调控免疫细胞, 进而发挥增强肠道免疫作用。本文主要综述了β-葡聚糖通过增强肠道免疫的作用途径和机制, 以及其发挥的生物学作用, 为进一步阐明β-葡聚糖与机体肠道相互作用的功能网络提供理论基础。

英文摘要:

      Intestinal tract is not only an important place for the digestion and absorption of nutrients in the body, but also an important barrier against external pathogens. Maintaining intestinal homeostasis and enhancing intestinal immune function are crucial for maintaining body health. β-glucan, as a dietary fiber, is also listed as a prebiotic, which has many biological activities. Such as immune regulation, antibacterial, anti-inflammatory and so on. It can participate in remodeling the composition and proportion of intestinal flora, maintaining and repairing the integrity of intestinal barrier, and regulating immune cells through direct or indirect (intestinal metabolite) pathways, and then play the role of enhancing intestinal immunity. This paper reviewed the pathway and mechanism of β-glucan through enhancing intestinal immunity and its further biological role, so as to provide a theoretical basis for further elucidating the functional network of β-glucan interaction with intestinal tract.