天然酚类化合物对呕吐毒素诱导毒性损伤保护作用的研究进展

Research progress of protection of natural phenolic compounds against deoxynivalenol-induced toxicity

中文关键词:  天然酚类化合物  呕吐毒素(Deoxynivalenol, DON)  毒性作用  保护机制

英文关键词:natural phenolic compounds  deoxynivalenol  toxicity  protective mechanism

中文摘要:

      呕吐毒素(deoxynivalenol, DON)是污染粮谷类食品和饲料最常见的霉菌毒素之一。人类和动物摄入被DON污染的食物后, 其肠道系统、免疫系统、神经系统、肝、肾、脾等器官和组织会发生不同程度的损伤, 甚至危及生命健康。天然酚类化合物具有安全无毒、来源广泛等优点, 并且具有抗氧化、抗炎、抗凋亡等特性, 逐渐被广泛应用于减缓由DON暴露引起的机体损伤。本文主要介绍DON的毒性作用, 并对国内外利用天然酚类化合物减缓DON诱导的毒性作用的保护机制研究进行综述, 以期为防控DON诱导的毒性损伤提供参考。

英文摘要:

      Deoxynivalenol (DON) is one of the most common mycotoxins in contaminated cereals and feeds. Human and animal ingestion of DON contaminated food, their intestinal system, immune system, nervous system, liver, kidney, spleen and other organs and tissues will occur varying degrees of damage, even life-threatening health. Natural phenolic compounds have the advantages of safety, non-toxicity, wide range of sources, which have antioxidant, anti-inflammatory, anti-apoptosis and other properties, and have gradually been widely used to mitigate the body damage caused by DON exposure. This paper mainly introduced the toxic effects of DON, and reviewed the domestic and foreign research on the protective mechanism of natural phenolic compounds to mitigate the toxic effects of DON, in order to provide a reference for the prevention and control of toxic damage induced by DON.