食源活性物质纳米靶向递送系统诱导米色脂肪生成研究进展

Research progress on beige adipogenesis induced by nano-targeted delivery system for food-derived bioactive factors

中文关键词:  肥胖  米色脂肪  靶向递送  纳米颗粒  食源活性物质

英文关键词:obesity  beige fat  targeted delivery  nanoparticle  food-derived bioactive factors

中文摘要:

      肥胖是一种全球性流行病, 与II型糖尿病、癌症和心血管疾病密切相关, 对人类健康构成了严重的威胁。近些年, 多种食源活性物质及其他生物活性因子已被证明可以通过诱导米色脂肪生成促进机体能量消耗, 成为预防和治疗肥胖的新策略。直接服用生物活性因子可能存在生物利用率低、无靶向特异性等缺陷。通过构建纳米靶向递送系统, 将生物活性因子包裹在纳米颗粒中, 靶向递送至脂肪组织, 可有效提高其生物利用率及稳态化, 实现精准递送。本文简要介绍了脂肪组织的功能及食源活性物质促进米色脂肪生成的机制, 综述了生物活性因子(食源活性物质、罗格列酮、甲状腺激素、信号通路激活剂/抑制剂)纳米靶向递送系统诱导米色脂肪生成的机制, 并阐述其治疗肥胖的最新研究进展, 以期为食源活性物质在功能性食品中的开发和应用提供理论依据。

英文摘要:

      Obesity is a global epidemic and closely related to type II diabetes, cancer and cardiovascular diseases, which poses a serious threat to health. In recent years, avariety of food-derived bioactive substances and other bioactive factors have been proved to promote the energy consumption by inducing beige fat formation, which has become a new strategy for the prevention and treatment of obesity. However, using these bioactive factors directly may have defects such as organ toxicity, low utilization rate and non-target specificity. Therefore, by constructing a nano-targeted delivery system, bioactive factors are wrapped in nanoparticles and then targeted to adipose tissue, which can effectively improve the stabilization and targeted delivery of bioactive factors. This paper briefly introduced the function of adipose tissue and the mechanism of food-derived bioactive substances promoting beige adipogenesis. Furthermore, this paper also reviewed the latest research progress on the beige fat production induced by nano-targeted delivery system for bioactive factors (food-derived bioactive factors, rosiglitazone, thyroid hormones, signaling pathway activators/inhibitors) in the treatment of obesity, aiming to provide a theoretical reference for the development and application of food-derived bioactive factors in functional food industry.