氟苯尼考及其代谢物氟苯尼考胺在肉鸡中残留消除规律

Residue elimination regularity of florfenicol and its metabolite florfenicol amine in broilers

中文关键词:  氟苯尼考  氟苯尼考胺  肉鸡  残留消除规律

英文关键词:florfenicol  florfenicol amine  broiler  residue elimination regularity

中文摘要:

      目的 评估氟苯尼考(florfenicol, FF)及其代谢物氟苯尼考胺(florfenicol amine, FFA)在不同品种肉鸡中的残留消除规律。方法 选用AA肉鸡、WOD168肉鸡(快速型)、雪山鸡和狼山鸡(慢速型)为试验对象, 于出栏前3周开始按FF 25 mg/kg体重饮水给药, 连用5 d, 于停药后1、3、5、7、10、14 d采集肌肉、肝脏、肾脏、皮脂, 检测其中的FF和FFA残留量, 并利用WT1.4软件计算休药期。结果 FF及其代谢物FFA可迅速残留于肉鸡肌肉、肝脏、肾脏和皮脂中, 残留物以FF为主。停药后第1 d残留量达到峰值, 肾脏组织中的残留量最大; 停药后第3 d, 各组织中FF和FFA的残留量进入快速消除期, 均低于最大残留限量值; 停药后第14 d已基本消除完全。AA肉鸡、WOD168肉鸡、雪山鸡和狼山鸡休药期分别至少为3.22、3.82、4.49和4.32 d。结论 FF在慢速型肉鸡体内的休药期要长于快速型肉鸡, 但都小于5 d。

英文摘要:

      Objective To evaluate the residue elimination regularity of florfenicol (FF) and its metabolite florfenicol amine (FFA) in different breeds of broilers. Methods AA broilers, WOD168 broilers (fast type), Xueshan chicken and Langshan chicken (slow type) were selected as test subjects. In the first 3 weeks of market age, chickens was administered FF orally at 25 mg/kg body weight of water for 5 days, and the muscle, liver, kidney and sebum were collected on days 1, 3, 5, 7, 10 and 14 after drug withdrawal. The residual amount of FF and FFA were detected, and the withdrawal period was calculated by WT1.4 software. Results FF and its main metabolite FFA could be quickly remained in muscle, liver, kidney and sebum, and FF was the main residue. The residual amount reached the peak on the 1st day after withdrawal, and the residual amount was largest in kidney. On the 3rd day after drug withdrawal, the residues of FF and FFA in all tissues entered the rapid elimination period, and were all lower than the maximum residue limit. The residues were almost eliminated completely on the 14th day after withdrawal. The withdrawal period of AA broilers, WOD168 broilers, Xueshan chicken and Langshan chicken were 3.22, 3.82, 4.49 and 4.32 days, respectively. Conclusion The withdrawal period of FF in slow type broilers is longer than that in fast type broilers, but both are less than 5 days.