鱼类恩诺沙星药物残留风险、成因与消减技术研究进展

Research progress on the risk of drug residues, formation cause and reduction technology of enrofloxacin in fish

中文关键词:  鱼类  恩诺沙星  药物残留风险  成因  消减技术

英文关键词:fish  enrofloxacin  risk of drug residues  formation cause  reduction technology

中文摘要:

      鱼类恩诺沙星(enrofloxacin, ENR)药物残留在市场与养殖环境频繁检出, 威胁人类健康与生态安全, 已成为公众日益关注的焦点。研究鱼类ENR药物残留控制技术对人类与环境可持续发展具有重要意义。本文对鱼类ENR药物残留现状、生态风险与鱼类ENR药物残留成因及其与鱼类ENR药效动力学、药代动力学关系进行了综述与分析, 指出最小杀菌浓度给药模式是鱼类与环境ENR药物残留根源。由此, 从鱼类ENR源头消减角度, 建议开展基于ENR最小抑菌浓度或与无药物残留中药抗菌剂联合的ENR减量用药研究; 从鱼类ENR药物残留代谢消除角度, 对易于形成ENR药物残留的鱼类, 建议进行促进鱼类ENR消除的中草药添加剂研究。本文可望为鱼类养殖过程ENR科学用药与水产品药物残留风险控制研究提供思路。

英文摘要:

      Enrofloxacin (ENR) drug residues in fish are frequently detected in the market and aquaculture environment, threatening human health and ecological safety, and have become the focus of public attention. Research on the control technology of ENR drug residues in fish is of great significance to the sustainable development of human beings and the environment. This paper reviewed and analyzed the current situation of ENR drug residues in fish, ecological risks and the causes of ENR drug residues in fish, as well as their relationship with the pharmacodynamics and pharmacokinetics of ENR in fish, and pointed out that the minimum bactericidal concentration administration mode was the root cause of ENR drug residues in fish and the environment. Therefore, from the perspective of fish ENR source reduction, this paper suggested to carry out the study of ENR reduction drug use based on the minimum inhibitory concentration of ENR or in combination with the non-drug residue traditional Chinese medicine antibacterial agent; from the perspective of metabolic elimination of ENR drug residues in fish, this paper suggested to study the Chinese herbal medicine additives that can promote the elimination of ENR drug residues in fish. This paper expected to provide ideas for the research of ENR scientific drug use and risk control of drug residues in aquatic products during fish culture.