抗氧化肽作用机制研究进展

Research progress on the mechanism of antioxidant peptides

中文关键词:  抗氧化肽  作用机制  氧化应激  生物活性肽

英文关键词:antioxidant peptide  mechanism of action  oxidative stress  bioactive peptide

中文摘要:

      过量活性氧(reactive oxygen species, ROS)造成的氧化应激日益成为人们迫切需要解决的问题。而由于化学合成抗氧化剂存在诸多缺陷, 人们逐渐将焦点转移至天然抗氧化剂。抗氧化肽由于来源广泛、安全性高、吸收性好等优点而备受瞩目。本文综述了抗氧化肽可能的作用机制, 包括直接清除自由基、螯合促氧化金属离子、调节产ROS氧化酶、增强抗氧化防御系统、细胞保护作用、调节肠道菌群等。重点介绍了抗氧化肽在调节产ROS氧化酶以及细胞保护作用中发挥的作用, 并指出抗氧化肽研究过程中亟需解决的问题, 以期为抗氧化肽的进一步研究提供一定的理论支撑。

英文摘要:

      Oxidative stress caused by excess reactive oxygen species (ROS) has increasingly became an urgent problem needs to be solved. However, due to the shortcomings of chemically synthesized antioxidants, people gradually shift the focus to natural antioxidants. Antioxidant peptides have attracted much attention because of their wide sources, high safety, and good absorption. This article reviewed the possible mechanism of antioxidant peptides, including direct scavenging free radicals, chelating pro-oxidative metal ions, regulating ROS-producing oxidases, enhancing antioxidant defense systems, protecting cells, and regulating intestinal flora, emphasized the role of antioxidant peptides in regulating ROS-producing oxidases and cytoprotective effects, and pointed out the urgent problems that should to be solved in the research process of antioxidant peptides, in order to provide certain theoretical support for further research on antioxidant peptides.