染料木素的代谢转化及功能活性研究进展

Research progress on metabolic transformation and functional activity of genistein

中文关键词:  染料木素  微生物代谢  结构  代谢转化  功能活性

英文关键词:genistein  metabolism  structure  metabolic transformation  functional activity

中文摘要:

      染料木素是一种源自大豆的异黄酮化合物, 具有调节胰岛素、抗癌、降血脂等多种生理和药理特性, 已经成为预防和治疗多种慢性疾病的潜在药物。近年来, 染料木素的生物转化已广泛应用于微生物代谢中, 主要涉及我国传统发酵豆制品和肠道菌群微生物代谢, 原理是利用菌群和酶促反应将异黄酮转化为具有生物活性的代谢物, 将结合型糖苷分解成游离型苷元及一系列代谢产物。本文综述了目前国内外染料木素的最新研究进展, 对其结构、代谢转化和功能活性进行了详细阐述, 并对染料木素的研究和应用进行展望, 认为未来的研究方向需进一步明确染料木素代谢产物对不同个体信号通路及肠道菌群的影响, 为开发理想的食品微生物发酵剂、开拓黄酮类化合物的利用范围提供了科学指导。

英文摘要:

      Genistein is an isoflavone compound derived from soybeans, it has a variety of physiological and pharmacological properties, such as regulating insulin, anti-cancer and lowering blood lipids, making it a potential drug for the prevention and treatment of many chronic diseases. In recent years, the biotransformation of genistein has been widely used in microbial metabolism, mainly involving the microbial metabolism of traditional fermented soybean products and intestinal flora, it is based on the principle of converting isoflavones into biologically active metabolites by using bacterial colonization and enzymatic reactions to break down bound glycosides into free glycosides and a series of metabolites. This article reviewed the latest research progress of genistein at home and abroad, elaborated its structure, metabolic transformation and functional activity, and prospected the research and application of genistein, it was suggested that the future research should further clarify the effects of genistein metabolites on different individual signaling pathways and intestinal flora, which provided scientific guidances for the development of ideal food microbial ferments and the exploitation of the flavonoids utilization range.