多肽螯合金属离子产物的研究进展

Research progress of peptide chelating metal ion products

中文关键词:  多肽  金属离子  制备  结构表征  分离纯化  生物利用度

英文关键词:polypeptide  metal ion  preparation  structural characterization  separation and purification  bioavailability

中文摘要:

      机体内存在的金属离子发挥着至关重要的作用, 金属元素的缺乏会导致不良症状的产生。目前市场上的金属元素补充剂价格较高或对胃肠道具有一定的刺激性, 因此急需高效廉价的新型补充剂来应对此类现状。其中, 由蛋白质水解产生的具有金属离子螯合性的多肽具有深远的研究意义。多肽金属离子螯合物是蛋白质水解产生的小分子多肽的羧基、磷酸基团、酰胺基团以及氨基酸等与金属离子通过配位共价结合或者吸附结合后产生的活性产物, 具有生物利用率高、安全性高、生物活性高等优点。本文综述了国内外金属离子螯合肽的制备、肽金属螯合物的结构表征、酶解物的分离纯化、螯合肽的生物利用率及螯合机制的相关研究, 并对目前现存在的问题进行总结, 以期对矿物质元素补充剂的研究与开发提供新思路。

英文摘要:

      Metal ions in the body play a vital role, the lack of metal elements will lead to adverse symptoms. At present, the price of metal element supplements in the market is high or has certain irritation to the gastrointestinal tract. Therefore, there is an urgent need for efficient and cheap new mineral supplements to deal with this situation. Among them, peptides with metal ion chelation produced by protein hydrolysis have far-reaching research significance. Peptide metal ion chelates are the active products produced by the carboxyl, phosphate, amide and amino acids of small molecular peptides produced by protein hydrolysis combined with metal ions through coordination covalent binding or adsorption, they have the advantages of high bioavailability, high safety and high biological activity. This paper reviewed the preparation of metal ion chelating peptides, structural characterization of peptide metal chelates, separation and purification of enzymatic hydrolysates, bioavailability of chelating peptides and chelating mechanism at home and abroad, and summarized the existing problems, so as to provide new ideas for the research and development of mineral element supplements.