食品接触材料中增塑剂毒性研究进展

Research progress on toxicity of plasticizer in food contact materials

中文关键词:  食品接触材料  新型增塑剂  生殖毒性

英文关键词:food contact materials  new plasticizer  reproductive toxicity

中文摘要:

      传统的聚氯乙烯(polyvinyl chloride, PVC)增塑剂邻苯二甲酸酯在使用过程中出现不同程度的迁移, 对人体存在潜在的致畸、致癌、致突变、生殖发育毒性等作用, 已被限制使用。新型增塑剂单独暴露毒性较低, 但新型增塑剂复合暴露是否存在毒性的问题迫切需要解决。本文主要阐述了邻苯二甲酸酯类增塑剂的生殖毒性、发育毒性, 并从结构、理化性质、单独暴露毒性方面介绍乙酰柠檬酸三丁酯、对苯二甲酸二辛酯、环己烷-1,2-二羧酸酯、聚酯4种食品药品领域常用的新型增塑剂及其毒性研究现状, 旨在为食品接触材料增塑剂的选择及使用提供理论参考。

英文摘要:

      The traditional polyvinyl chloride (PVC) plasticizer phthalate has different degrees of migration during the use of food, which has potential teratogenic, carcinogenic, mutagenic and reproductive toxicity to human body, and has been restricted from use. The toxicity of new plasticizers exposed alone is low, but the problem of toxicity of new plasticizers exposed in combination needs to be solved urgently. This paper mainly expounded the reproductive toxicity and developmental toxicity of phthalate plasticizers, and introduced 4 kinds of new plasticizers commonly used in food and drug fields, namely acetyl tributyl citrate, dioctyl terephthalate, diisononyl cyclohexane-1,2- dicarboxylate and polyester, and their toxicity research status from the aspects of structure, physical and chemical properties and single exposure toxicity, in order to provide theoretical references for the selection and use of plasticizers for food contact materials.