赭曲霉毒素A的生物合成和调控机制研究进展

Research progress on biosynthesis and regulation mechanism of ochratoxin A

中文关键词:  赭曲霉毒素A  合成途径  调控机制  全局调控因子

英文关键词:ochratoxin A  synthetic pathway  regulation mechanism  global regulatory factor

中文摘要:

      赭曲霉毒素A (ochratoxin A, OTA)是一种由曲霉或青霉产生的次级代谢产物。赭曲霉毒素A不仅有肾毒性、肝毒性、免疫毒性、致畸致癌致突变性, 还有肠道毒性, 对人体有多种毒害作用。赭曲霉毒素A的合成途径已取得了一定的研究进展, 但一些中间产物和相关酶仍然需要进一步验证。本文对OTA的毒性、与OTA合成有关的基因、生物合成途径、全局调控因子、途径特异性调控因子和环境信号、防控策略和脱毒等进行了综述, 以期对OTA的合成途径有更进一步的认识, 对OTA的产生和防控提供科学的理论参考。

英文摘要:

      Ochratoxin A (OTA) is a secondary metabolite produced by Aspergillus or Penicillium. OTA not only has nephrotoxicity, hepatotoxicity, immunotoxicity, teratogenicity, carcinogenicity and mutagenicity, but also has intestinal toxicity, which has many toxic effects on human body. The synthetic pathway of OTA has made some progress, but some intermediate products and related enzymes still need further verification. This paper reviewed the toxicity, genes related to OTA synthesis, biosynthetic pathways, global regulatory factors, pathway-specific regulatory factors and environmental signals, prevention, control strategies and detoxification of OTA, in order to have a further understanding of OTA synthesis pathway, and provide scientific theoretical reference for OTA generation and prevention and control.