甲壳类氨基脲的来源及检测方法研究进展

Research progress on the source and detection method of crustacean semicarbazide

中文关键词:  甲壳类水产品  氨基脲  来源  内源性物质

英文关键词:crustacean aquatic products  semicarbazide  source  endogenous substance

中文摘要:

      氨基脲(semicarbazide, SEM)作为呋喃西林的代谢产物, 在动物体内能够与蛋白质形成稳定的结合物, 难以代谢完全, 人体摄入后会产生一些毒理作用。通常以氨基脲为检测目标来判别甲壳类水产品中呋喃西林的使用情况, 但根据现有的研究结果发现, 除呋喃西林源氨基脲外, 其他途径也能产生氨基脲, 目前已知的途径包括: 环境摄入、加工过程中使用次氯酸钠消毒、偶氮甲酰胺的分解及内源性氨基脲的存在。在目前我国水产贸易中, 甲壳类水产品中内源性氨基脲的天然存在为呋喃西林药物检测带来了严重的影响和干扰, 致使无法准确地判定氨基脲的来源。因此本文总结了食品中氨基脲的各种可能来源, 并介绍了现行的氨基脲检测方法, 在此基础上进一步预测了有关内源性氨基脲的可能产生途径, 以帮助确定甲壳类水产品中氨基脲的来源途径, 从而准确检测氨基脲。

英文摘要:

      Semicarbazide (SEM), as a metabolite of nitrofurazone, can form a stable combination with protein in animal body, which is difficult to metabolize completely, and will produce some toxicological effects after ingestion. Semicarbazide is usually used as the detection target to judge the use of nitrofurazone in crustacean aquatic products. However, according to the existing research results, semicarbazide can be produced by other ways besides semicarbazide from nitrofurazone. Currently, the known ways include environmental intake, disinfection with sodium hypochlorite during processing, decomposition of azoformamide and existence of endogenous semicarbazide. In the current aquatic trade in China, the natural existence of endogenous semicarbazide in crustacean aquatic products has brought serious influence and interference to the detection of nitrofurazone, which makes it impossible to accurately determine the source of semicarbazide. Therefore, this paper summarized various possible sources of semicarbazide in food, and introduced the current detection methods of semicarbazide. On this basis, further predicted the possible production pathways of endogenous semicarbazide, to help determine the source pathways of semicarbazide in crustacean aquatic products and accurately detect semicarbazide.