植物多糖免疫调节作用机制研究进展

Advances in research on the mechanism of immunomodulatory effects of plant polysaccharides

中文关键词:  植物多糖  免疫调节  构效关系  作用机制

英文关键词:plant polysaccharide  immune regulation  structure-activity relationship  mechanism of action

中文摘要:

      多糖作为生物体内广泛存在的一类生物大分子物质, 是构成生物体的重要物质, 同时还具有抗病毒、抑菌、抗肿瘤和降血糖等重要的生理活性。目前, 植物多糖提高机体免疫力的功能研究引起了国内外学者的广泛关注; 越来越多的研究表明, 植物多糖可作为一种天然药物被广泛使用。本文综述了植物多糖对固有性免疫、适应性免疫、细胞因子和机体免疫信息等方面的免疫调节和作用机制, 及植物多糖的结构特征与构效关系研究, 展望了植物多糖在促进细胞因子的分泌、促进抗体生成和红细胞免疫功能理论基础研究的前景和发展方向, 以期为植物多糖免疫活性研究提供理论参考, 并对植物多糖免疫调节机制的更深层次研究提供思路。

英文摘要:

      Polysaccharide, as a kind of biological macromolecules which is widely existing in organisms, is the main substances of biological organisms, and it also has important physiological activities such as antiviral, antibacterial, antitumor and hypoglycemic. At present, the function research of plant polysaccharides for improving the body's immunity was widely concerned from scholars at home and abroad; more and more studies have shown that it can be widely used as a natural medicine. This article reviewed the mechanism of immune regulation of plant polysaccharides on innate immunity, adaptive immunity, cytokines and body immune information, as well as the research on the structural characteristics and structure-activity relationship of plant polysaccharides, it was expected that plant polysaccharides can promote the secretion of cytokines, promoted the prospects and development directions of the theoretical basic research on antibody production and red blood cell immune function, which could provide a theoretical reference for the research on the immune activity of plant polysaccharides, and a deeper research ideas of the immune regulation mechanisms about plant polysaccharides.