液相色谱-串联质谱法测定金属罐中三(壬基酚)亚磷酸酯的迁移量

Determination of migration of tris (nonylphenyl) phosphite from metal cans by liquid chromatography-tandem mass spectrometry

中文关键词:  液相色谱-串联质谱法  金属包装  三(壬基酚)亚磷酸酯  迁移量

英文关键词:liquid chromatography-tandem mass spectrometry  metal packaging  tris(nonylphenyl)phosphite  migration

中文摘要:

      目的 建立液相色谱-串联质谱法检测金属罐中三(壬基酚)亚磷酸酯迁移量的分析方法。方法 金属罐经水、4%乙酸、10%乙醇、20%乙醇、50%乙醇等食品模拟物迁移后, 过滤, 采用大气压化学电离(atmosphere pressure chemical ionization, APCI)和多反应监测模式(multiple reaction monitoring, MRM)进行检测, 外标法定量。结果 三(壬基酚)亚磷酸酯在10~500 μg/L范围内呈现良好的线性关系, 相关系数不低于0.9997, 检出限为0.005 mg/L, 测定结果的相对标准偏差不大于5%(n=6), 加标回收率为94.20%~106.40%。结论 该方法准确、精密度好, 可用于金属罐中三(壬基酚)亚磷酸酯迁移量的快速检测。

英文摘要:

      Objective To establish a method for the determination of migration of tris (nonylphenyl) phosphite from metal cans by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Methods The metal cans were migrated in food simulants, such as water, 4% acetic acid, 10% ethanol, 20% ethanol, 50% ethanol. Then the food simulants were detected by atmosphere pressure chemical ionization (APCI) using multiple reaction monitoring (MRM) after filtering, and quantified by external standard method. Results The calibration curve of tris (nonylphenyl) phosphite had good linearity in the range of 10?500 μg/L, with correlation coefficients not less than 0.9997. The detection limit of tris (nonylphenyl) phosphite was 0.005 mg/L. The relative standard deviation was less than 5% (n=6), and the recoveries ranged from 94.20% to 106.40%. Conclusion This method is accurate and precise, and can be used to determine the migration of tris (nonylphenyl) phosphite from metal cans rapidly.