人参皂苷活性对冠心病作用的研究进展

Research progress of ginsenosides activity on coronary heart disease

中文关键词:  人参皂苷  冠心病  治疗机制  药理效应

英文关键词:ginsenosides  coronary heart disease  therapeutic mechanism  pharmacological effects

中文摘要:

      冠心病的发病率和病死率占心血管疾病的首位, 严重危害着人类健康。人参是我国和东南亚地区应用历史悠久的药食两用养生珍品, 具有提高机体免疫力、缓解疲劳、抗衰老等功效。近年来, 国内外学者对人参皂苷的主要化学成分、药理效应及在冠心病方面的临床应用进行了大量研究。本文主要综述了人参主要的活性成分, 人参皂苷的分类及毒性, 人参活性成分与炎症反应、氧化应激、细胞凋亡、细胞自噬、线粒体损伤、钙超载的关系, 以及人参皂苷在抗动脉粥样硬化、抗心律失常、抗心肌缺血、抑制心室重构方面的作用, 并进行了系统归纳, 以期为利用人参皂苷活性成分研发新型冠心病药物提供理论基础, 为进一步提高人参皂苷活性的研究水平、扩大临床应用提供科学依据。

英文摘要:

      The incidence rate and mortality rate of coronary heart disease account for the first place in cardiovascular disease, which seriously endangers human health. Ginseng has a long history of medical and food dual-purpose health care treasures from China to Southeast Asia. It can improve immunity, relieve fatigue and anti-aging. In recent years, scholars at home and abroad have done a lot of research on the main chemical components, pharmacological effects and clinical application of ginsenosides in coronary heart disease. This paper reviewed the main active components of ginseng, the classification and toxicity of ginsenosides. The relationship between active components of ginseng and inflammation, oxidative stress, apoptosis, autophagy, mitochondrial damage, calcium overload were introduced. The effects of ginsenosides on anti atherosclerosis, anti arrhythmia, anti myocardial ischemia and inhibition of ventricular remodeling were introduced and summarized systematically, in order to provide a theoretical basis for the development of new coronary heart disease drugs using ginseng active ingredients, and to provide scientific basis for further improving the research level of ginsenoside activity and expanding clinical application.