肠炎沙门氏菌中侵袭相关毒力基因研究进展

Research progress of invasion-related virulence genes in Salmonella enteritidis

中文关键词:  肠炎沙门氏菌  侵袭性感染  毒力基因

英文关键词:Salmonella enteritidis  invasive infection  virulence genes

中文摘要:

      沙门氏菌为食源性疾病常见病原体, 据其引起疾病的不同症状可分为伤寒沙门氏菌和非伤寒沙门氏菌, 前者主要引起人全身或局部器官的侵袭性感染, 后者多致胃肠道疾病。但近年来研究表明部分非伤寒沙门氏菌也具较强侵袭力, 肠炎沙门氏菌则是引起侵袭性感染的重要沙门氏菌血清型, 其侵入吞噬细胞和非吞噬细胞的能力是引起感染的关键步骤, 众多毒力基因编码侵袭蛋白参与该过程, 大部分研究集中于鞭毛基因及SPI-1上的毒力基因如inv、sip、hil等, 此外仍有许多功能尚未明确的基因如yhbC有待探索。研究大多集中于单个基因致病机制, 但致病过程往往由众多毒力基因协调配合, 尚未准确掌握其生物特性及致病机制。本文阐述了近年来肠炎沙门氏菌与侵袭相关的毒力基因, 期望为肠炎沙门氏菌侵袭性感染的致病机制提供新的研究思路, 为其预防、早期诊断及治疗提供有力证据。

英文摘要:

      Salmonella is a common foodborne pathogen. According to the different symptoms of the disease, Salmonella can be divided into Salmonella typhi and non-typhoid Salmonella. The former mainly causes systemic infection and local organ infection, and the latter mostly causes gastrointestinal diseases. However, recent studies have shown that some non-typhoid Salmonella have also strong invasion ability. Salmonella enteritidis is an important Salmonella serotype that causes invasive infections. Its ability to invade phagocytes and non-phagocytes is a key step in causing infection. Many virulence genes encode invasion proteins involve in this process. Most research focuses on flagellar genes and virulence genes on SPI-1 such as inv, sip, hil, etc. In addition, there are still many genes whose functions are not yet clear, such as yhbC. Most studies explore the pathogenic mechanism of a single gene, but the pathogenic process is often coordinated by many virulence genes, and its biological characteristics and pathogenic mechanism have not been accurately grasped. This paper elaborated the virulence genes related to invasion of Salmonella enteritidis in recent years in order to provide new research ideas for the pathogenic mechanism of invasive infection of Salmonella enteritidis and strong evidence for its prevention, early diagnosis and treatment.