高效液相色谱-串联质谱法测定猪肉中氯丙嗪残留量的不确定度评定

Uncertainty evaluation for determination of chlorpromazine residues in pork by high performance liquid chromatography-tandem mass spectrometry

中文关键词:  高效液相色谱-串联质谱法  猪肉  氯丙嗪  不确定度

英文关键词:high performance liquid chromatography-tandem mass spectrometry  pork  chlorpromazine  uncertainty

中文摘要:

      目的 评定高效液相色谱-串联质谱法测定猪肉中氯丙嗪残留量的不确定度。方法 参考 GB/T 20763—2006《猪肾和肌肉组织中乙酰丙嗪、氯丙嗪、氟哌啶醇、丙酰二甲氨基丙吩噻嗪、甲苯噻嗪、阿扎哌隆、阿扎哌醇、咔唑心安残留量的测定 液相色谱-串联质谱法》和JJF 1059.1—2012《测量不确定度评定与表示》中的规定与要求, 分析氯丙嗪在测定过程中的各种不确定度来源。结果 当猪肉中氯丙嗪残留量为 8.863 μg/kg时, 其扩展不确定度为1.278 μg/kg (k=2)。结论 影响不确定度的主要因素是样品前处理、配制标准溶液和标准溶液线性拟合过程。

英文摘要:

      Objective To evaluate the uncertainty for determination of chlorpromazine residues in pork by high performance liquid chromatography-tandem mass spectrometry. Methods According to the provisions and requirements in GB/T 20763—2006 Method for determination of acetopromaizine, chlorpromazine, haloperidol, propionylpromazine, xylazine, azaperone, azaperol and carazolol residues in porcine kidney and muscle tissues-LC-MS-MS method and JJF 1059.1—2012 Evaluation and expression of measurement uncertainty, the sources of various uncertainties in the determination process of chlorpromazine were analyzed. Results When the residual amount of chlorpromazine in pork was 8.863 μg/kg, the expanded uncertainty was 1.278 μg/kg (k=2). Conclusion The main factors affecting the uncertainty are sample pretreatment, preparation of standard solution and linear fitting process of standard solution